A role for the integrin alphavbeta8 in the negative regulation of epithelial cell growth.

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

1993 • 5,680 citations

Mortality by cause for eight regions of the world: Global Burden of Disease Study

1997 • 4,053 citations

Antigen retrieval in formalin-fixed, paraffin-embedded tissues: an enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections.

1991 • 2,598 citations

Role of cell shape in growth control

1978 • 2,434 citations

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1990 • 2,129 citations

Estimates of the worldwide mortality from 25 cancers in 1990

1999 • 1,494 citations

Reversion of the Malignant Phenotype of Human Breast Cells in Three-Dimensional Culture and In Vivo by Integrin Blocking Antibodies

1997 • 1,444 citations

Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism.

1995 • 938 citations

CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cells.

1994 • 922 citations

Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin.

1995 • 840 citations

Integrin distribution in malignant melanoma: association of the beta 3 subunit with tumor progression.

1990 • 771 citations

Episomal Vectors Rapidly and Stably Produce High-Titer Recombinant Retrovirus

1996 • 768 citations

Integrin cytoplasmic domains mediate inside-out signal transduction

1994 • 682 citations

Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains.

1995 • 620 citations

Novel purification of vitronectin from human plasma by heparin affinity chromatography.

1988 • 525 citations

Control of Cyclin D1, p27^Kip1, and Cell Cycle Progression in Human Capillary Endothelial Cells by Cell Shape and Cytoskeletal Tension

1998 • 476 citations

Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorylation of the retinoblastoma protein.

1996 • 453 citations

P53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features

1992 • 448 citations

A Link Between Cyclin A Expression and Adhesion-Dependent Cell Cycle Progression

1993 • 399 citations

Anchorage-dependent Cell Cycle Progression

1997 • 384 citations

Involvement of integrin alpha V gene expression in human melanoma tumorigenicity.

1992 • 380 citations

Focal Adhesion Kinase Overexpression Enhances Ras-dependent Integrin Signaling to ERK2/Mitogen-activated Protein Kinase through Interactions with and Activation of c-Src

1997 • 380 citations

Dependence of Cyclin E-CDK2 Kinase Activity on Cell Anchorage

1996 • 371 citations

Extracellular matrix signaling: integration of form and function in normal and malignant cells

1998 • 360 citations

Regulation of the Cell Cycle by Focal Adhesion Kinase

1998 • 346 citations

Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain.

1994 • 331 citations

Mutations of ras genes distinguish a subset of non-small-cell lung cancer cell lines from small-cell lung cancer cell lines

1992 • 298 citations

Identification of amino acid sequences in the integrin beta 1 cytoplasmic domain implicated in cytoskeletal association

1992 • 285 citations

Splicing by overlap extension by PCR using asymmetric amplification: an improved technique for the generation of hybrid proteins of immunological interest

1997 • 283 citations

Number and Proliferation of Basal and Parabasal Cells in Normal Human Airway Epithelium

1998 • 261 citations

Role of the integrin alpha v beta 6 in cell attachment to fibronectin. Heterologous expression of intact and secreted forms of the receptor.

1994 • 250 citations

Tissue structure, nuclear organization, and gene expression in normal and malignant breast.

1999 • 247 citations

Integrin alpha 5 beta 1 expression negatively regulates cell growth: reversal by attachment to fibronectin.

1995 • 247 citations

Purification and functional characterization of integrin alpha v beta 5. An adhesion receptor for vitronectin.

1990 • 238 citations

Complete amino acid sequence of a novel integrin beta subunit (beta 6) identified in epithelial cells using the polymerase chain reaction.

1990 • 195 citations

Requirement of the NPXY motif in the integrin beta 3 subunit cytoplasmic tail for melanoma cell migration in vitro and in vivo.

1995 • 186 citations

Collagen matrix promotes reorganization of pancreatic endocrine cell monolayers into islet-like organoids.

1983 • 185 citations

Cloning and expression of a divergent integrin subunit beta 8.

1991 • 179 citations

Quantitation of membrane glycoprotein IIIa on intact human platelets using the monoclonal antibody, AP-3

1985 • 175 citations

Correlation of Intrinsic Chemoresistance of Non-Small-Cell Lung Cancer Cell Lines With HER-2/neu Gene Expression but Not With ras Gene Mutations

1993 • 170 citations

The alpha v beta 6 integrin promotes proliferation of colon carcinoma cells through a unique region of the beta 6 cytoplasmic domain.

1994 • 165 citations

Asbestos induces apoptosis of human and rabbit pleural mesothelial cells via reactive oxygen species.

1996 • 160 citations

The integrin αvβ6 is critical for keratinocyte migration on both its known ligand, fibronectin, and on vitronectin

1998 • 153 citations

Smad4/DPC4 Silencing and Hyperactive Ras Jointly Disrupt Transforming Growth Factor-β Antiproliferative Responses in Colon Cancer Cells

1999 • 146 citations

Synaptic and glial localization of the integrin αvβ8 in mouse and rat brain

1998 • 146 citations

Differential Effects of the Integrins α9β1, αvβ3, and αvβ6 on Cell Proliferative Responses to Tenascin

1996 • 141 citations

Activation of the p21 Pathway of Growth Arrest and Apoptosis by the β4 Integrin Cytoplasmic Domain

1995 • 136 citations

Regulation of P21cip1 Expression by Growth Factors and the Extracellular Matrix Reveals a Role for Transient ERK Activity in G1 Phase

1999 • 135 citations

Review: The Integrin α_vβ₃: Angiogenesis and Apoptosis

1995 • 134 citations

Inhibition of Cell Cycle Progression by the Alternatively Spliced Integrin β_1C

1995 • 123 citations

Integrin alpha v beta 8. Interaction with vitronectin and functional divergence of the beta 8 cytoplasmic domain.

1994 • 122 citations

Differential regulation of airway epithelial integrins by growth factors.

1996 • 97 citations

Expression of integrin cell adhesion receptors during human airway epithelial repair in vivo

1997 • 93 citations

Distribution of Integrin Cell Adhesion Receptors on Normal Bronchial Epithelial Cells and Lung Cancer Cells In Vitro and In Vivo

1993 • 92 citations

Structural cues from the tissue microenvironment are essential determinants of the human mammary epithelial cell phenotype.

1998 • 86 citations

Characterization of immortal cystic fibrosis tracheobronchial gland epithelial cells.

1992 • 86 citations

Microinjection of monoclonal antibody PAb421 into human SW480 colorectal carcinoma cells restores the transcription activation function to mutant p53.

1995 • 85 citations

Ice Rhythms—Core Reveals a Plethora of Climate Cycles

1996 • 79 citations

Alternatively spliced variants: A new view of the integrin cytoplasmic domain

1997 • 77 citations

β1-Integrin Cytoplasmic Subdomains Involved in Dominant Negative Function

1998 • 76 citations

Expression of beta 1B integrin isoform in CHO cells results in a dominant negative effect on cell adhesion and motility.

1994 • 76 citations

Distribution of vitronectin mRNA during murine development

1995 • 66 citations

β1D Integrin Inhibits Cell Cycle Progression in Normal Myoblasts and Fibroblasts

1998 • 64 citations

Integrin cytoplasmic domains as connectors to the cell's signal transduction apparatus

1997 • 59 citations

The Novel Structural Motif Gln795–Gln802 in the Integrin β1C Cytoplasmic Domain Regulates Cell Proliferation

1995 • 57 citations

p27kip1 acts as a downstream effector of and is coexpressed with the β1C integrin in prostatic adenocarcinoma

1999 • 55 citations

Vitronectin in Bronchoalveolar Lavage Fluid Is Increased in Patients with Interstitial Lung Disease

1991 • 43 citations

[20] Polymerase chain reaction cloning with degenerate primers: Homology-based identification of adhesion molecules

1994 • 38 citations

Isolation and Characterization of Basal Cells from Human Upper Respiratory Epithelium

1997 • 31 citations

Airway Epithelial Integrins: Why So Many?

1998 • 28 citations

Effects of β Subunit Cytoplasmic Domain Deletions on the Recruitment of the Integrin αvβ6 to Focal Contacts

1994 • 26 citations

Identification of a Sequence within the Integrin β6 Subunit Cytoplasmic Domain That Is Required to Support the Specific Effect of αvβ6 on Proliferation in Three-dimensional Culture

1996 • 25 citations

Elevated Levels of Bronchoalveolar Lavage Vitronectin in Hypersensitivity Pneumonitis

1993 • 23 citations

Plasma Physicists Seek New Uses for the Legacy of Fusion

1995 • 4 citations