Chromatin decouples promoter threshold from dynamic range

The Human Genome Browser at UCSC

2002 • 9,920 citations

Sequencing and comparison of yeast species to identify genes and regulatory elements

2003 • 1,785 citations

Twenty-Five Years of the Nucleosome, Fundamental Particle of the Eukaryote Chromosome

1999 • 1,774 citations

Cooperation between Complexes that Regulate Chromatin Structure and Transcription

2002 • 1,474 citations

Genome-Scale Identification of Nucleosome Positions in S. cerevisiae

2005 • 1,113 citations

The Nucleosome

2004 • 636 citations

A Systems Approach to Measuring the Binding Energy Landscapes of Transcription Factors

2007 • 593 citations

Yeast-enhanced green fluorescent protein (yEGFP): a reporter of gene expression in Candida albicans

1997 • 590 citations

Removal of positioned nucleosomes from the yeast PHO5 promoter upon PHO5 induction releases additional upstream activating DNA elements.

1986 • 470 citations

Nucleosomes Unfold Completely at a Transcriptionally Active Promoter

2003 • 402 citations

Phosphate in Microorganisms: Cellular and Molecular Biology

1994 • 366 citations

Phosphorylation of the Transcription Factor PHO4 by a Cyclin-CDK Complex, PHO80-PHO85

1994 • 361 citations

Intrinsic Histone-DNA Interactions and Low Nucleosome Density Are Important for Preferential Accessibility of Promoter Regions in Yeast

2005 • 333 citations

Regulation of PHO4 Nuclear Localization by the PHO80-PHO85 Cyclin-CDK Complex

1996 • 326 citations

Roles of Phosphorylation Sites in Regulating Activity of the Transcription Factor Pho4

1999 • 324 citations

Nucleosome displacement in transcription: Figure 1.

2006 • 306 citations

Chromatin Disassembly Mediated by the Histone Chaperone Asf1 Is Essential for Transcriptional Activation of the Yeast PHO5 and PHO8 Genes

2004 • 293 citations

Single amino acid substitutions alter helix-loop-helix protein specificity for bases flanking the core CANNTG motif.

1992 • 199 citations

Crystal structure of PHO4 bHLH domain-DNA complex: flanking base recognition

1997 • 196 citations

Collaborative Competition Mechanism for Gene Activation In Vivo

2003 • 180 citations

Transcriptional Activators Are Dispensable for Transcription in the Absence of Spt6-Mediated Chromatin Reassembly of Promoter Regions

2006 • 167 citations

The two positively acting regulatory proteins PHO2 and PHO4 physically interact with PHO5 upstream activation regions.

1989 • 160 citations

A nucleosome precludes binding of the transcription factor Pho4 in vivo to a critical target site in the PHO5 promoter.

1994 • 134 citations

Whole-genome comparison of Leu3 binding in vitro and in vivo reveals the importance of nucleosome occupancy in target site selection

2006 • 130 citations

The transactivation domain of Pho4 is required for nucleosome disruption at the PHO5 promoter.

1994 • 121 citations

Partially Phosphorylated Pho4 Activates Transcription of a Subset of Phosphate-Responsive Genes

2003 • 102 citations

An intracellular phosphate buffer filters transient fluctuations in extracellular phosphate levels

2005 • 96 citations

Evidence for Histone Eviction in trans upon Induction of the Yeast PHO5 Promoter

2004 • 95 citations

A chromatin-mediated mechanism for specification of conditional transcription factor targets

2006 • 90 citations

Cooperative Pho2-Pho4 Interactions at the PHO5 Promoter Are Critical for Binding of Pho4 to UASp1 and for Efficient Transactivation by Pho4 at UASp2

1998 • 75 citations

Promoter Occupancy Is a Major Determinant of Chromatin Remodeling Enzyme Requirements

2005 • 51 citations

Activation of the weakly regulated PHO8 promoter inS.cerevisiae:chromatin transition and binding sites for the positive regulatory protein PHO4

1992 • 50 citations

Structure and distribution of specific cis-elements for transcriptional regulation of PH084 in Saccharomyces cerevisiae

1995 • 45 citations

The homeodomain protein Pho2p binds at an A/T-rich segment flanking the binding site of the basic-helix-loop-helix protein Pho4p in the yeastPHO promoters

1997 • 11 citations