Acetylcholinesterase Catalysis - Protein Engineering Studies

A new and rapid colorimetric determination of acetylcholinesterase activity

1961 • 25,114 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Atomic Structure of Acetylcholinesterase from Torpedo californica : A Prototypic Acetylcholine-Binding Protein

1991 • 2,613 citations

Acetylcholinesterase: enzyme structure, reaction dynamics, and virtual transition states

1987 • 1,044 citations

Interaction of fluorescence probes with acetylcholinesterase. Site and specificity of propidium binding

1975 • 357 citations

Responses of acetylcholinesterase from Torpedo marmorata to salts and curarizing drugs.

1966 • 308 citations

Molecular cloning and construction of the coding region for human acetylcholinesterase reveals a G + C-rich attenuating structure.

1990 • 208 citations

Identification of the structural mutation responsible for the dibucaine-resistant (atypical) variant form of human serum cholinesterase.

1989 • 191 citations

Isolation and characterization of full-length cDNA clones coding for cholinesterase from fetal human tissues.

1987 • 176 citations

Acetylcholinesterase of human erythrocytes and neuromuscular junctions: homologies revealed by monoclonal antibodies.

1982 • 154 citations

Cholinesterase-like domains in enzymes and structural proteins: functional and evolutionary relationships and identification of a catalytically essential aspartic acid.

1991 • 146 citations

Mutagenesis of essential functional residues in acetylcholinesterase.

1990 • 140 citations

Primary structures of the catalytic subunits from two molecular forms of acetylcholinesterase. A comparison of NH2-terminal and active center sequences.

1985 • 126 citations

Cholinesterases. Structure, function, mechanism, genetics and cell biology.

1991 • 122 citations

Anionic subsites of the acetylcholinesterase from Torpedo californica: affinity labelling with the cationic reagent N,N-dimethyl-2-phenyl-aziridinium.

1990 • 111 citations

Brain cDNA clone for human cholinesterase.

1987 • 104 citations

The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expression of acetylcholinesterase Cys-580—-Ala mutant.

1991 • 99 citations

Cholinesterases : structure, function, mechanism, genetics, and cell biology

1991 • 84 citations

Phenotypic and molecular biological analysis of human butyrylcholinesterase variants

1990 • 75 citations

Chemical Structure and Function of the Active Center of Acetylcholinesterase^*

1966 • 75 citations

Production and characterization of separate monoclonal antibodies to human acetylcholinesterase and butyrylcholinesterase.

1983 • 74 citations

Recombinant human acetylcholinesterase is secreted from transiently transfected 293 cells as a soluble globular enzyme

1991 • 55 citations

On the origins of esterases.

1988 • 54 citations

Choline acetyltransferase and acetylcholinesterase. Evidence for essential histidine residues

1974 • 49 citations

Anionic site interactions in human butyrylcholinesterase disrupted by two single point mutations.

1990 • 46 citations

Sequence determination of a peptide fragment from electric eel acetylcholinesterase, involved in the binding of quaternary ammonium

1986 • 45 citations

Anionic subsites of the catalytic center of acetylcholinesterase from Torpedo and from cobra venom.

1991 • 45 citations

Specific residues within an amino-terminal domain of 35 residues of interferon alpha are responsible for recognition of the human interferon alpha cell receptor and for triggering biological effects.

1987 • 41 citations

Kinetic, equilibrium and spectroscopic studies on cation association at the active center of acetylcholinesterase: topographic distinction between trimethyl and trimethylammonium sites

1986 • 28 citations

Acetylcholinesterase: Theory of noncompetitive inhibition

1986 • 13 citations