A Quantitative Study of Microglial—Macrophage Synthesis of Tumor Necrosis Factor during Acute and Late Focal Cerebral Ischemia in Mice

The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation

1995 • 1,979 citations

Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1.

1986 • 1,501 citations

Control of Synaptic Strength by Glial TNFα

2002 • 1,277 citations

Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors

1996 • 947 citations

TNFα promotes proliferation of oligodendrocyte progenitors and remyelination

2001 • 941 citations

Tumor Necrosis Factor-α

1997 • 864 citations

Tumor necrosis factor-alpha expression in ischemic neurons.

1994 • 793 citations

Tumour necrosis factor as immunomodulator and mediator of monocyte cytotoxicity induced by itself, γ-interferon and interleukin-1

1986 • 781 citations

Targeting gene-modified hematopoietic cells to the central nervous system: Use of green fluorescent protein uncovers microglial engraftment

2001 • 618 citations

Increase in IL-6, IL-1 and TNF levels in rat brain following traumatic lesion

1993 • 517 citations

Tumor necrosis factor-α

1991 • 508 citations

Production of hemolymphopoietic cytokines (IL-6, IL-8, colony-stimulating factors) by normal human astrocytes in response to IL-1 beta and tumor necrosis factor-alpha.

1992 • 402 citations

Cloning and expression in Escherichia coli of the cDNA for murine tumor necrosis factor.

1985 • 394 citations

Glyceraldehyde-3-phosphate dehydrogenase mRNA is a major interleukin 2-induced transcript in a cloned T-helper lymphocyte

1990 • 391 citations

Polymorphonuclear leukocyte infiltration into cerebral focal ischemic tissue: Myeloperoxidase activity assay and histologic verification

1991 • 382 citations

The many faces of tumor necrosis factor in stroke

2002 • 369 citations

Mice deficient in TNF receptors are protected against dopaminergic neurotoxicity: Implications for Parkinson's disease

2002 • 366 citations

TNF-α Pretreatment Induces Protective Effects against Focal Cerebral Ischemia in Mice

1997 • 346 citations

Soluble forms of tumor necrosis factor receptors (TNF-Rs). The cDNA for the type I TNF-R, cloned using amino acid sequence data of its soluble form, encodes both the cell surface and a soluble form of the receptor.

1990 • 335 citations

Microglia and Macrophages Are the Major Source of Tumor Necrosis Factor in Permanent Middle Cerebral Artery Occlusion in Mice

2000 • 310 citations

Stimulation of human T-cell proliferation by specific activation of the 75-kDa tumor necrosis factor receptor.

1993 • 297 citations

A second tumor necrosis factor receptor gene product can shed a naturally occurring tumor necrosis factor inhibitor.

1990 • 292 citations

Concomitant cortical expression of TNF-α and IL-1β mRNAs follows early response gene expression in transient focal ischemia

1994 • 278 citations

Expression of TNF and TNF Receptors (p55 and p75) in the Rat Brain after Focal Cerebral Ischemia

1997 • 269 citations

Estimation of the number of somatostatin neurons in the striatum: An in situ hybridization study using the optical fractionator method

1996 • 259 citations

Ischemic and Excitotoxic Brain Injury is Enhanced in Mice Lacking the p55 Tumor Necrosis Factor Receptor

1998 • 254 citations

Involvement of inflammatory cytokines in central nervous system injury

2002 • 251 citations

Expression of tumor necrosis factor alpha after focal cerebral ischaemia in the rat

1996 • 247 citations

Tumor necrosis factor: a master-regulator of leukocyte movement

2000 • 242 citations

Chemokine networks in vivo: involvement of C-X-C and C-C chemokines in neutrophil extravasation in vivo in response to TNF-alpha.

1997 • 237 citations

Quantitative Real-Time RT—PCR Analysis of Inflammatory Gene Expression Associated with Ischemia—Reperfusion Brain Injury

2002 • 231 citations

Migration of enhanced green fluorescent protein expressing bone marrow-derived microglia/macrophage into the mouse brain following permanent focal ischemia

2003 • 228 citations

Inhibition of Receptor Internalization by Monodansylcadaverine Selectively Blocks p55 Tumor Necrosis Factor Receptor Death Domain Signaling

1999 • 199 citations

Evolution of Cerebral Tumor Necrosis Factor-α Production During Human Ischemic Stroke

2001 • 195 citations

Inhibition of Tumor Necrosis Factor and Amelioration of Brain Infarction in Mice

1997 • 190 citations

Inhibition of tumor necrosis factor-alpha reduces focal cerebral ischemic injury in the spontaneously hypertensive rat

1996 • 190 citations

Inhibition of TNFα attenuates infarct volume and ICAM-1 expression in ischemic mouse brain

1998 • 169 citations

Induction of Tumor Necrosis Factor-α in the Mouse Hippocampus following Transient Forebrain Ischemia

1997 • 167 citations

Factors determining the therapeutic window for stroke

1998 • 145 citations

Interleukins and Tumor Necrosis Factor in Inflammation

1990 • 129 citations

Role of NMDA receptor signaling in the regulation of inflammatory gene expression after focal brain ischemia

2000 • 117 citations

Chapter 28 Endogenous pyrogens in the CNS: role in the febrile response

1992 • 94 citations

Exclusive tumor necrosis factor (TNF) signaling by the p75TNF receptor triggers inflammatory ischemia in the CNS of transgenic mice

2003 • 84 citations

Cellular expression of tumor necrosis factor a and its receptors in human ischemic stroke.

2003 • 78 citations

Membrane Tumor Necrosis Factor (TNF) Induced Cooperative Signaling of TNFR60 and TNFR80 Favors Induction of Cell Death Rather Than Virus Production in HIV-infected T Cells

1997 • 76 citations

Cytotoxic Potential of Proinflammatory Cytokines: Combined Deletion of TNF Receptors TNFR1 and TNFR2 Prevents Motoneuron Cell Death after Facial Axotomy in Adult Mouse

2002 • 75 citations

IFNγ Enhances Microglial Reactions to Hippocampal Axonal Degeneration

2000 • 70 citations

Differential cellular expression of tumor necrosis factor-α and Type I tumor necrosis factor receptor after transient global forebrain ischemia

2001 • 68 citations

Involvement of the tumor necrosis factor receptor p75 in mediating cytotoxicity and gene regulating activities

1994 • 66 citations

Differential induction of interleukin-1β and tumour necrosis factor-α may account for specific patterns of leukocyte recruitment in the brain

2002 • 64 citations

Microglial—Macrophage Synthesis of Tumor Necrosis Factor after Focal Cerebral Ischemia in Mice is Strain Dependent

2002 • 64 citations

DNA array reveals altered gene expression in response to focal cerebral ischemia

2002 • 54 citations

Neutrophils secreting tumor necrosis factor alpha infiltrate the central nervous system of BALB/c mice with experimental autoimmune encephalomyelitis

1998 • 43 citations

A specific and sensitive method for visualization of tumor necrosis factor in the murine central nervous system

2001 • 39 citations

Cooperative Signaling by Tumor Necrosis Factor Receptors CD120a (p55) and CD120b (p75) in the Expression of Nitric Oxide and Inducible Nitric Oxide Synthase by Mouse Macrophages

1998 • 36 citations

Differential Regulation of IL-1β and TNF-α RNA Expression by MEK1 Inhibitor after Focal Cerebral Ischemia in Mice

2001 • 34 citations

Cross-linking of the p55 Tumor Necrosis Factor Receptor Cytoplasmic Domain by a Dimeric Ligand Induces Nuclear Factor-κB and Mediates Cell Death

1995 • 28 citations

THE ROLE OF THE TWO TNF RECEPTORS IN PROLIFERATION, NF-κB ACTIVATION AND DISCRIMINATION BETWEEN TNF AND LTαSIGNALLING IN THE HUMAN MYELOMA CELL LINE OH-2

1996 • 27 citations

Pharmacological profile and anti-ischemic properties of the Ca(2+)-channel blocker NS-638.

1995 • 26 citations

Expression of the 75 kDA TNF receptor and its role in contact-mediated neuronal cell death

1998 • 23 citations

Pharmacological profile and anti-ischemic properties of the Ca2+-channel blocker NS-638

1995 • 20 citations