Towards an understanding of the malignant transformation of diploid human fibroblasts

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1983 • 2,871 citations

Expression of recessive alleles by chromosomal mechanisms in retinoblastoma

1983 • 1,952 citations

Xeroderma pigmentosum. Cutaneous, ocular, and neurologic abnormalities in 830 published cases

1987 • 1,070 citations

Cellular tumorigenicity in nude mice: Correlation with cell growth in semi-solid medium

1974 • 814 citations

Xeroderma Pigmentosum

1974 • 755 citations

Tumorigenicity of virus-transformed cells in nude mice is correlated specifically with anchorage independent growth in vitro.

1975 • 747 citations

Identification of transforming gene in two human sarcoma cell lines as a new member of the ras gene family located on chromosome 1

1983 • 441 citations

Mutation and childhood cancer: a probabilistic model for the incidence of retinoblastoma.

1975 • 353 citations

Evidence for the Recessive Nature of Cellular Immortality

1983 • 286 citations

DNA excision-repair processes in human cells can eliminate the cytotoxic and mutagenic consequences of ultraviolet irradiation

1979 • 245 citations

Carcinogenesis: Fundamental Mechanisms and Environmental Effects

1980 • 231 citations

Desmoid Tumors in Familial Polyposis Coli

1986 • 208 citations

The Nude mouse in experimental and clinical research

1978 • 205 citations

Neoplastic transformation of human diploid fibroblast cells by chemical carcinogens

1978 • 204 citations

Induction of immortality is an early event in malignant transformation of mammalian cells by carcinogens

1982 • 174 citations

The occurrence of desmoids in patients with familial polyposis coli

1970 • 164 citations

Neoplastic transformation of human diploid cells in vitro after chemical carcinogen treatment

1978 • 164 citations

Testing the Commitment Theory of Cellular Aging

1977 • 154 citations

In vitro transformation of human epithelial cells

1986 • 148 citations

Rapid clonal growth and serial passage of human diploid fibroblasts in a lipid-enriched synthetic medium supplemented with epidermal growth factor, insulin, and dexamethasone.

1981 • 139 citations

Human cell transformation by simian virus 40—A review

1981 • 135 citations

Induction of anchorage independence in human diploid foreskin fibroblasts by carcinogenic metal salts.

1987 • 130 citations

Neoplastic transformation of human diploid fibroblasts (KMST‐6) by treatment with ⁶⁰Co gamma rays

1985 • 127 citations

Synthesis and secretion of proteins resembling platelet-derived growth factor by human glioblastoma and fibrosarcoma cells in culture.

1985 • 125 citations

Expression of a variant form of actin and additional polypeptide changes following chemical-induced in vitro neoplastic transformation of human fibroblasts.

1980 • 125 citations

Studies on repair of adenovirus 2 by human fibroblasts using normal, xeroderma pigmentosum, and xeroderma pigmentosum heterozygous strains.

1974 • 121 citations

Frequency of UV-induced neoplastic transformation of diploid human fibroblasts is higher in xeroderma pigmentosum cells than in normal cells.

1982 • 101 citations

X-ray-induced in vitro Neoplastic transformation of human diploid cells

1980 • 101 citations

Variations in expression of mutant β actin accompanying incremental increases in human fibroblast tumorigenicity

1982 • 91 citations

Tropomyosin isoform switching in tumorigenic human fibroblasts.

1986 • 86 citations

Extent of excision repair before DNA synthesis determines the mutagenic but not the lethal effect of UV radiation

1982 • 82 citations

Ultraviolet light-induced transformation of human cells to anchorage-independent growth.

1980 • 79 citations

Chromosome changes during the in vitro ageing of MRC-5 human fibroblasts

1975 • 77 citations

Extracolonic manifestations of familial polyposis coli

1987 • 74 citations

Anchorage-independent growth of normal human fibroblasts.

1981 • 72 citations

Induction of anchorage-independent growth in human fibroblasts by propane sultone.

1981 • 67 citations

Genetic predisposition to cancer

2005 • 67 citations

Expression of Transfected Mutant β-actin Genes: Transitions Toward the Stable Tumorigenic State

1987 • 63 citations

Changes in gene expression accompanying chemically-induced malignant transformation of human fibroblasts

1982 • 62 citations

Spontaneous Immortalization Rate of Cultured Chinese Hamster Cells2

1986 • 57 citations

Usage of vertebrate, invertebrate and plant cell, tissue and organ culture terminology

1984 • 57 citations

Morphological transformation, focus formation, and anchorage independence induced in diploid human fibroblasts by expression of a transfected H-ras oncogene.

1987 • 55 citations

Carcinogenesis in vitro

1975 • 52 citations

XERODERMA PIGMENTOSUM FIBROBLASTS INCLUDING CELLS FROM XP VARIANTS ARE ABNORMALLY SENSITIVE TO THE MUTAGENIC AND CYTOTOXIC ACTION OF BROAD SPECTRUM SIMULATED SUNLIGHT

1984 • 51 citations

Characterization of human cells transformed by chemical and physical carcinogens in vitro

1981 • 47 citations

Multistep process of neoplastic transformation of normal human fibroblasts by ⁶⁰CO gamma rays and harvey sarcoma viruses

1986 • 46 citations

Spontaneous, mutagen‐induced and adenovirus‐induced anchorage independent tumorigenic variants of mouse cells

1979 • 46 citations

Expression of transfected mutant beta-actin genes: transitions toward the stable tumorigenic state.

1987 • 45 citations

Multi-step neoplastic transformation of normal human fibroblasts by Co-60 gamma rays and Ha-ras oncogenes

1988 • 42 citations

Abnormal sensitivity of human fibroblasts from xeroderma pigmentosum variants to transformation to anchorage independence by ultraviolet radiation.

1986 • 41 citations

Characteristics of human diploid fibroblasts transformed in vitro by chemical carcinogens.

1983 • 40 citations

Action spectra for ultraviolet light-induced transformation of human cells to anchorage-independent growth.

1981 • 39 citations

Modification of MCDB 110 medium to support prolonged growth and consistent high cloning efficiency of diploid human fibroblasts

1987 • 38 citations

Banbury Report 12: Nitrosamines and Human Cancer

1983 • 36 citations

Quantitation of contact-feeding between somatic cells in culture

1975 • 35 citations

Identification and order of sequential mutations in beta-actin genes isolated from increasingly tumorigenic human fibroblast strains.

1985 • 35 citations

Conditions for transformation of human fibroblast cells: An overview

1986 • 34 citations

Multiple activated oncogenes in human tumors.

1987 • 33 citations

Characteristics of WI-38 cells (WI-38 CT-1) transformed by treatment with Co-60 gamma rays.

1980 • 30 citations

Culture conditions induce the appearance of immortalized C3H mouse cell lines

1984 • 29 citations

Spontaneous In Vitro Transformation of Human Fibroblasts<xref ref-type="fn" rid="FN2">2</xref>

1984 • 28 citations

Defect in UV-induced unscheduled DNA synthesis in cultured epidermal keratinocytes from xeroderma pigmentosum

1987 • 25 citations

Characterization of a quantitative assay for the in vitro transformation of normal human diploid fibroblasts to anchorage independence by chemical carcinogens.

1983 • 25 citations

Carcinogenesis in tissue culture. 29: Neoplastic transformation of a normal human diploid cell strain, WI-38, with Co-60 gamma rays.

1978 • 25 citations

Neoplastic human fibroblast proteins are related to epidermal growth factor precursor.

1984 • 23 citations

Short Communication: Carcinogen-induced anchorage-independent growth and in vivo lethality of human MRC-5 cells

1981 • 21 citations

60Coガンマ線照射で形質転換したWI‐38細胞(WI‐38CT‐1)の特徴

1980 • 21 citations

Transformation of diploid human fibroblasts by DNA transfection with the v‐sis oncogene

1986 • 19 citations

Spontaneous transformation of human fibroblast cultures derived from bronchial carcinomata

1976 • 19 citations

Starvation for arginine and glutamine sensitizes human diploid cells to the transforming effects of N-acetoxy-2-acetyl-aminofluorene

1981 • 18 citations

Spontaneous in vitro malignant transformation in a xeroderma pigmentosum fibroblast line

1983 • 18 citations

Transformation of diploid human fibroblasts by transfection with the v-sis, PDGF2/c-sis, or T24 H-ras genes

1988 • 16 citations

Comparison of features of carcinogen-transformed human cells in vitro with sarcoma-derived cells

1988 • 15 citations

The transformed (initiated) human cell phenotype: study of cultured skin fibroblasts from individuals predisposed to cancer

1988 • 15 citations

Human fibroblasts from cancer patients: lifespan and transformed phenotype in vitro and role of mesenchyme in vivo

1988 • 14 citations

Benzo[a]pyrene diol epoxide DNA adduct formation in transformable and non-transformable human foreskin fibroblast cells in vitro

1982 • 13 citations

Ultraviolet radiation-induced neoplastic transformation of normal human cells, in vitro

1981 • 12 citations

Transformation of Diploid Human Fibroblasts by Chemical Carcinogens

1980 • 9 citations

Chemical and viral transformation of cultured skin fibroblasts from patients with familial polyposis coli

1988 • 8 citations

Macromolecular changes accompanying immortalization and tumorigenic conversion in a human fibroblast model system

1988 • 8 citations

Differential growth response of normal human diploid fibroblasts and in vitro transformed human fibroblasts in serum‐free defined culture medium

1984 • 6 citations

Oncogenic potential in fibroblasts from individuals genetically predisposed to cancer

1988 • 6 citations

Transformation studies on human fibroblasts from familial polyposis coli patients and normal donors

1988 • 5 citations

Human cell transformation in the study of sunlight-induced cancers in the skin of man

1988 • 5 citations

Methods for quantifying carcinogen-induced transformation of diploid human fibroblasts to anchorage independence

1986 • 5 citations

⁶⁰Co radiation-induced transformation to anchorage independence of fibroblasts from normal persons and patients with inherited predisposition to retinoblastoma

1986 • 4 citations

In Vitro Malignant Transformation — A Multi-Stepped Process

1985 • 3 citations

The study of multi-stage carcinogenesis in retinoblastoma and familial polyposis coli patient-derived skin fibroblast cell culture systems

1988 • 3 citations

CHEMICALLY-INDUCED IN VITRO MALIGNANT TRANSFORMATION OF HUMAN ESOPHAGUS FIBROBLASTS

1980 • 2 citations

Malignant transformation of human fetal lung fibroblasts induced by nitrosamine compounds in vitro.

1986 • 2 citations

Cytologic comparison of a human fibroblast culture chemically transformed in vitro with its non-neoplastic parent cell strain.

1978 • 1 citations

'In vitro' studies on chemical carcinogenesis.

1972 • 1 citations