Disruption of PAX6 function in mice homozygous for the Pax6Sey-1Neu mutation produces abnormalities in the early development and regionalization of the diencephalon

Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity

1993 • 2,146 citations

Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse.

1995 • 1,782 citations

Genetic variants and strains of the laboratory mouse

1990 • 1,519 citations

Pax-6, a murine paired box gene, is expressed in the developing CNS

1991 • 1,226 citations

Mouse Small eye results from mutations in a paired-like homeobox-containing gene

1991 • 1,124 citations

Pax-3, a novel murine DNA binding protein expressed during early neurogenesis.

1991 • 897 citations

Positional cloning and characterization of a paired box- and homeobox-containing gene from the aniridia region

1991 • 850 citations

Conservation of the hedgehog/patched signaling pathway from flies to mice: induction of a mouse patched gene by Hedgehog.

1996 • 829 citations

Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds

1993 • 800 citations

Expression patterns of homeobox and other putative regulatory genes in the embryonic mouse forebrain suggest a neuromeric organization

1993 • 777 citations

PAX6 gene dosage effect in a family with congenital cataracts, aniridia, anophthalmia and central nervous system defects

1994 • 683 citations

Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo

1993 • 680 citations

The role ofPax-6in eye and nasal development

1995 • 660 citations

Longitudinal organization of the anterior neural plate and neural tube

1995 • 647 citations

Genomic structure, evolutionary conservation and aniridia mutations in the human PAX6 gene

1992 • 643 citations

Roles of Pax-genes in developing and adult brain as suggested by expression patterns

1994 • 582 citations

Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2, and Wnt- 3 in the embryonic day 12.5 mouse forebrain defines potential transverse and longitudinal segmental boundaries

1993 • 570 citations

The Embryonic Vertebrate Forebrain: the Prosomeric Model

1994 • 530 citations

Expression of Three Mouse Homologs of the Drosophila Segment Polarity Gene cubitus interruptus, Gli, Gli-2, and Gli-3, in Ectoderm- and Mesoderm-Derived Tissues Suggests Multiple Roles during Postimplantation Development

1994 • 478 citations

Midline signalling is required for Pax gene regulation and patterning of the eyes

1995 • 433 citations

Segmental organization of embryonic diencephalon

1993 • 395 citations

Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins.

1996 • 380 citations

Forebrain patterning defects in Small eye mutant mice

1996 • 379 citations

Signals from the notochord and floor plate regulate the region-specific expression of two Pax genes in the developing spinal cord

1993 • 356 citations

Small eyes (Sey) : a homozygous lethal mutation on chromosome 2 which affects the differentiation of both lens and nasal placodes in the mouse

1986 • 344 citations

Signals from the notochord and floor plate regulate the region-specific expression of two Pax genes in the developing spinal cord

1993 • 326 citations

A mutation in the Pax-6 gene in rat small eye is associated with impaired migration of midbrain crest cells

1993 • 309 citations

Oligodendrocytes originate in a restricted zone of the embryonic ventral neural tube defined by DM-20 mRNA expression

1995 • 296 citations

Determination of Neuroepithelial Cell Fate: Induction of the Oligodendrocyte Lineage by Ventral Midline Cells and Sonic Hedgehog

1996 • 279 citations

Sequence and expression pattern ofpax-6are highly conserved between zebrafish and mice

1992 • 264 citations

Segment‐related, mosaic neurogenetic pattern in the forebrain and mesencephalon of early chick embryos: I. Topography of ache‐positive neuroblasts up to stage HH18

1987 • 257 citations

Expression pattern of zebrafish pax genes suggests a role in early brain regionalization

1991 • 255 citations

Multiple functions for Pax6 in mouse eye and nasal development.

1996 • 231 citations

Evidence that pioneer olfactory axons regulate telencephalon cell cycle kinetics to induce the formation of the olfactory bulb

1995 • 222 citations

Regulatory gene expression boundaries demarcate sites of neuronal differentiation in the embryonic zebrafish forebrain

1994 • 213 citations

Isolation and characterization of a novel cDNA clone encoding a homeodomain that is developmentally regulated in the ventral forebrain

1991 • 209 citations

Expression of winged helix genes, BF‐1 and BF‐2, define adjacent domains within the developing forebrain and retina

1994 • 208 citations

Defects of neuronal migration and the pathogenesis of cortical malformations are associated with Small eye (Sey) in the mouse, a point mutation at the Pax-6-locus

1993 • 200 citations

GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity.

1990 • 180 citations

DM‐20 mRNA Is Expressed During the Embryonic Development of the Nervous System of the Mouse

1992 • 173 citations

Fetal Brain Subdivisions Defined by R- and E-Cadherin Expressions: Evidence for the Role of Cadherin Activity in Region-Specific, Cell–Cell Adhesion

1995 • 157 citations

A gene with sequence similarity to Drosophila engrailed is expressed during the development of the neural tube and vertebrae in the mouse

1988 • 144 citations

The Origin of Spinal Cord Oligodendrocytes Is Dependent on Local Influences from the Notochord

1996 • 113 citations

Sequence and expression pattern of the Stra7 (Gbx‐2) homeobox‐containing gene induced by retinoic acid in P19 embryonal carcinoma cells

1995 • 104 citations

Quail Pax-6 (Pax-QNR) encodes a transcription factor able to bind and trans-activate its own promoter.

1993 • 92 citations

Regionalized expression of the Dbx family homeo☐ genes in the embryonic CNS of the mouse

1996 • 71 citations

cDNA Cloning of a Murine Homologue ofDrosophilaSingle-Minded, Its mRNA Expression in Mouse Development, and Chromosome Localization

1996 • 49 citations

Induction of agenesis of the corpus callosum by the destruction of anlage of the olfactory bulb using fetal laser surgery exo utero in mice

1993 • 23 citations

A SEM study on the development of the ventricular surface morphology in the diencephalon of the rat

1988 • 10 citations