Rapid detection of genotypes and mutations in the pre-core promoter and the pre-core region of hepatitis B virus genome: correlation with viral persistence and disease severity

Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis

1981 • 3,549 citations

Classification of chronic hepatitis: Diagnosis, grading and staging

1994 • 2,506 citations

Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate

1982 • 1,429 citations

MUTATION PREVENTING FORMATION OF HEPATITIS B e ANTIGEN IN PATIENTS WITH CHRONIC HEPATITIS B INFECTION

1989 • 1,210 citations

Complete Genomes, Phylogenetic Relatedness, and Structural Proteins of Six Strains of the Hepatitis B Virus, Four of Which Represent Two New Genotypes

1994 • 804 citations

Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen

1990 • 525 citations

Hepatitis B virus with mutations in the core promoter for an e antigen-negative phenotype in carriers with antibody to e antigen

1994 • 493 citations

Effects of a naturally occurring mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replication

1996 • 474 citations

Mutations in the pre-core region of hepatitis B virus serve to enhance the stability of the secondary structure of the pre-genome encapsidation signal.

1994 • 375 citations

Wild-type and e antigen-minus hepatitis B viruses and course of chronic hepatitis.

1991 • 370 citations

Chronic hepatitis in HBsAg carriers with serum HBV-DNA and Anti-HBe

1986 • 334 citations

Core Promoter Mutations and Genotypes in Relation to Viral Replication and Liver Damage in East Asian Hepatitis B Virus Carriers

1999 • 304 citations

Second-generation line probe assay for hepatitis C virus genotyping

1996 • 288 citations

Hepatitis B virus genotype A rarely circulates as an HBe-minus mutant: possible contribution of a single nucleotide in the precore region

1993 • 266 citations

Different hepatitis b virus genotypes are associated with different mutations in the core promoter and precore regions during hepatitis B e antigen seroconversion

1999 • 266 citations

Naturally Occurring Variants of Hepatitis B Virus

1999 • 261 citations

High prevalence of 1762T 1764A mutations in the basic core promoter of hepatitis B virus isolated from black africans with hepatocellular carcinoma compared with asymptomatic carriers

1999 • 258 citations

Active hepatitis B virus replication in the presence of anti-HBe is associated with viral variants containing an inactive pre-C region

1990 • 205 citations

Hepatitis B virus infection: Precore mutants and its relation to viral genotypes and core mutations

1995 • 193 citations

Enhanced replication of a hepatitis B virus mutant associated with an epidemic of fulminant hepatitis

1994 • 182 citations

The duck hepatitis B virus pre-C region encodes a signal sequence which is essential for synthesis and secretion of processed core proteins but not for virus formation

1987 • 182 citations

Expression of the precore region of an avian hepatitis B virus is not required for viral replication

1987 • 166 citations

Biologic Properties of Hepatitis B Viral Genomes with Mutations in the Precore Promoter and Precore Open Reading Frame

1997 • 163 citations

Long-term follow-up of anti-HBe-positive chronic active hepatitis B

1988 • 138 citations

The secretory core protein of human hepatitis B virus is expressed on the cell surface

1989 • 130 citations

Analysis of hepatitis B virus genotypes and pre-core region variability during interferon treatment of HBe antigen negative chronic hepatitis B

1996 • 129 citations

Replication capacities of natural and artificial precore stop codon mutants of hepatitis B virus: Relevance of pregenome encapsidation signal

1992 • 120 citations

Comparison of methods for detection of hepatitis B virus DNA

1994 • 117 citations

Hepatitis B virus nucleocapsid particles do not cross the hepatocyte nuclear membrane in transgenic mice

1994 • 109 citations

Hepatitis B virus carriers without precore mutations in hepatitis B e antigen-negative stage show more severe liver damage

1996 • 107 citations

Wild-type levels of pregenomic RNA and replication but reduced pre-C RNA and e-antigen synthesis of hepatitis B virus with C(1653) --> T, A(1762) --> T and G(1764) --> A mutations in the core promoter.

1998 • 104 citations

Frequent and rapid emergence of mutated pre-C sequences in HBV from e-antigen positive carriers who seroconvert to anti-HBe during interferon treatment

1992 • 93 citations

The clinical significance of molecular variation within the hepatitis B virus genome

1992 • 80 citations

Therapies for viral hepatitis.

1998 • 67 citations

Predictive value of precore hepatitis B virus mutations in spontaneous and interferon-induced hepatitis B e antigen clearance

1995 • 67 citations

Changes in the prevalence of HBeAg-negative mutant hepatitis B virus during the course of chronic hepatitis B

1994 • 64 citations

Comparison of anti-HBe-positive and HBe-antigen-positive chronic hepatitis B in France

1994 • 63 citations

Evidence for a base-paired region of hepatitis B virus pregenome encapsidation signal which influences the patterns of precore mutations abolishing HBe protein expression

1993 • 63 citations

Rapid detection and further characterization of infection with hepatitis B virus variants containing a stop codon in the distal pre-C region

1990 • 58 citations

Therapies for viral hepatitis

1999 • 57 citations

The Stem-Loop Structure of the cis-Encapsidation Signal Is Highly Conserved in Naturally Occurring Hepatitis B Virus Variants

1994 • 51 citations

Early and frequent detection of HBxAg and/or anti-HBx in hepatitis B virus infection

1990 • 48 citations

Three Cases of Severe Subfulminant Hepatitis in Heart–Transplanted Patients After Nosocomial Transmission of A Mutant Hepatitis B Virus

1999 • 44 citations

Analysis of Hepatitis B Virus Populations in an Interferon-α-Treated Patient Reveals Predominant Mutations in the C-Gene and Changing e-Antigenicity

1998 • 38 citations

Antibodies in Anti-HBe—positive patient sera bind to an HBe protein expressed on the cell surface of human hepatoma cells: Implications for virus clearance

1991 • 34 citations

Low frequency of precore hepatitis B virus mutants in anti-hepatitis B e—positive reactivation after loss of hepatitis B e antigen in patients with chronic hepatitis B

1995 • 34 citations

The precore sequence of hepatitis B virus is required for nuclear localization of the core protein

1997 • 16 citations

Predictive value of precore hepatitis B virus mutations in spontaneous and interferon-induced hepatitis B e antigen clearance*1, *2

1995 • 12 citations

Clinical evaluation of the branched DNA assay for hepatitis B virus DNA detection in patients with chronic hepatitis B lacking hepatitis B e antigen and treated with interferon‐α

1998 • 11 citations

Low frequency of precore hepatitis B virus mutants in anti-hepatitis B e-positive reactivation after loss of Hepatitis B e antigen in patients with chronic Hepatitis B*1

1995 • 11 citations

Antibodies in anti-HBe-positive patient sera bind to an HBe protein expressed on the cell surface of human hepatoma cells: Implications for virus clearance

1991 • 6 citations