Enhanced replication of a hepatitis B virus mutant associated with an epidemic of fulminant hepatitis

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Development of Virus-Like Particle Technology from Small Highly Symmetric to Large Complex Virus-Like Particle Structures

2013 • 5,819 citations

MUTATION PREVENTING FORMATION OF HEPATITIS B e ANTIGEN IN PATIENTS WITH CHRONIC HEPATITIS B INFECTION

1989 • 1,210 citations

Typing Hepatitis B Virus by Homology in Nucleotide Sequence: Comparison of Surface Antigen Subtypes

1988 • 1,057 citations

Protective Effects of a Live Attenuated SIV Vaccine with a Deletion in the nef Gene

1992 • 1,025 citations

Nucleotide sequence of the hepatitis B virus genome (subtype ayw) cloned in E. coli

1979 • 992 citations

Fulminant and Subfulminant Liver Failure: Definitions and Causes

1986 • 629 citations

Hepatitis B virus genes and their expression in E. coli

1979 • 584 citations

Mutations in the Precore Region of Hepatitis B Virus DNA in Patients with Fulminant and Severe Hepatitis

1991 • 536 citations

Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen

1990 • 525 citations

A Hepatitis B Virus Mutant Associated with an Epidemic of Fulminant Hepatitis

1991 • 468 citations

Tbe complete nudeotide sequences of the cloned hepatitis B vims DNA; subtype adr and adw

1983 • 426 citations

A short cis-acting sequence is required for hepatitis B virus pregenome encapsidation and sufficient for packaging of foreign RNA.

1990 • 412 citations

Globin mRNA Sequences: Analysis of Base Pairing and Evolutionary Implications

1978 • 403 citations

The role of envelope proteins in hepatitis B virus assembly.

1991 • 389 citations

Mutational analysis of the hepatitis B virus P gene product: domain structure and RNase H activity

1990 • 355 citations

Structural and pathological effects of synthesis of hepatitis B virus large envelope polypeptide in transgenic mice.

1987 • 353 citations

Cloning and structural analyses of hepatitis B virus DNAs, subtypeadr

1983 • 309 citations

Polymerase gene products of hepatitis B viruses are required for genomic RNA packaging as well as for reverse transcription

1990 • 309 citations

THE NUCLEOTIDE SEQUENCE OF THE HEPATITIS B VIRAL GENOME AND THE IDENTIFICATION OF THE MAJOR VIRAL GENES

1980 • 277 citations

A specific base transition occurs on replicating hepatitis delta virus RNA

1990 • 260 citations

Fulminant hepatitis B: Induction by hepatitis B virus mutants defective in the precore region and incapable of encoding E antigen

1991 • 255 citations

A new hepatitis B virus strain in patients with severe anti-HBe positive chronic hepatitis B

1990 • 229 citations

Morphogenetic and regulatory effects of mutations in the envelope proteins of an avian hepadnavirus

1991 • 198 citations

The amino-terminal domain of the hepadnaviral P-gene encodes the terminal protein (genome-linked protein) believed to prime reverse transcription.

1988 • 198 citations

Complete nucleotide sequence of hepatitis B virus DNA of subtype adr and its conserved gene organization

1984 • 196 citations

High-level expression of hepatitis B viral antigens in fibrosing cholestatic hepatitis

1992 • 192 citations

Precore mutant hepatitis B virus infection and liver disease

1992 • 173 citations

Variations in codons 84-101 in the core nucleotide sequence correlate with hepatocellular injury in chronic hepatitis B virus infection.

1992 • 172 citations

Nucleotide Sequence of a Cloned Hepatitis B Virus Genome, Subtype ayr: Comparison with Genomes of the Other Three Subtypes

1986 • 163 citations

Hepatitis B virus X protein is not central to the viral life cycle in vitro

1992 • 154 citations

Subtype ayw variant of hepatitis B virus

1985 • 154 citations

Naturally occurring missense mutation in the polymerase gene terminating hepatitis B virus replication

1991 • 151 citations

Relationship Between Expression of Hepatitis B Virus Antigens in Isolated Hepatocytes and Autologous Lymphocyte Cytotoxicity in Patients with Chronic Hepatitis B Virus Infection

1984 • 142 citations

The precore gene of the woodchuck hepatitis virus genome is not essential for viral replication in the natural host

1992 • 137 citations

Novel catalytic activity associated with positive-strand RNA virus infection: nucleic acid-stimulated ATPase activity of the plum pox potyvirus helicaselike protein

1991 • 118 citations

Three envelope proteins of hepatitis B virus: large S, middle S, and major S proteins needed for the formation of Dane particles

1991 • 112 citations

High affinity monoclonal antibodies to hepatitis B surface antigen (HBsAg) produced by somatic cell hybrids

1981 • 97 citations

Genetic mapping of lymphocytic choriomeningitis virus pathogenicity: virulence in guinea pigs is associated with the L RNA segment

1985 • 89 citations

Genetic variation in hepatitis B virus

1992 • 85 citations

High-Frequency Transfection and Cytopathology of the Hepatitis B Virus Core Antigen Gene in Human Cells

1983 • 85 citations

Demonstration of two distinct antigenic determinants on hepatitis B e antigen by monoclonal antibodies.

1982 • 83 citations

The clinical significance of molecular variation within the hepatitis B virus genome

1992 • 80 citations

Association of hepatitis B viral precore mutations with fulminant hepatitis B in Japan

1991 • 69 citations

Serologic Markers with Fulminant Hepatitis in Persons Positive for Hepatitis B Surface Antigen

1988 • 69 citations

Virulence of La Crosse virus is under polygenic control

1986 • 66 citations

Identification of a promoter region for 3.6-kilobase mRNA of hepatitis B virus and specific cellular binding protein

1989 • 66 citations

The nucleotide sequence and reading frames of a mutant hepatitis B virus subtypeadr

1989 • 63 citations

Hepatitis B virus core antigen (HBc Ag) accumulation in an HBV nonproducer clone of HepG2-transfected cells is associated with cytopathic effect

1990 • 62 citations

Rapid identification of low level hepatitis B-related viral genome in serum.

1989 • 55 citations

A system for studying the selective encapsidation of hepadnavirus RNA

1989 • 36 citations

Naturally occurring point mutation in the C terminus of the polymerase gene prevents duck hepatitis B virus RNA packaging

1992 • 23 citations

Encapsidation of truncated human hepatitis b virus genomes through trans-complementation of the core protein and polymerase

1990 • 19 citations

The core gene of hepatits B virus; subtype adw2

1988 • 6 citations