Predictive value of precore hepatitis B virus mutations in spontaneous and interferon-induced hepatitis B e antigen clearance

Avoiding false positives with PCR

1989 • 3,564 citations

MUTATION PREVENTING FORMATION OF HEPATITIS B e ANTIGEN IN PATIENTS WITH CHRONIC HEPATITIS B INFECTION

1989 • 1,210 citations

Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen

1990 • 525 citations

A short cis-acting sequence is required for hepatitis B virus pregenome encapsidation and sufficient for packaging of foreign RNA.

1990 • 412 citations

Mutations in the pre-core region of hepatitis B virus serve to enhance the stability of the secondary structure of the pre-genome encapsidation signal.

1994 • 375 citations

Wild-type and e antigen-minus hepatitis B viruses and course of chronic hepatitis.

1991 • 370 citations

Which patients with chronic hepatitis B virus infection will respond to α-interferon therapy? A statistical analysis of predictive factors

1989 • 306 citations

Novel mechanism for reverse transcription in hepatitis B viruses

1993 • 299 citations

Identification of HBV variants which cannot produce pre-core derived HBeAg and may be responsible for severe hepatitis

1989 • 263 citations

An RNA stem-loop structure directs hepatitis B virus genomic RNA encapsidation

1993 • 250 citations

A controlled trial of interferon with or without prednisone priming for chronic hepatitis B

1992 • 242 citations

Acute exacerbations in Chinese patients with chronic hepatitis B virus (HBV) infection

1990 • 236 citations

Hepatitis B virus unable to secrete e antigen and response to interferon in chronic hepatitis B

1993 • 183 citations

The duck hepatitis B virus pre-C region encodes a signal sequence which is essential for synthesis and secretion of processed core proteins but not for virus formation

1987 • 182 citations

Precore mutant hepatitis B virus infection and liver disease

1992 • 173 citations

A signal peptide encoded within the precore region of hepatitis B virus directs the secretion of a heterogeneous population of e antigens in Xenopus oocytes.

1988 • 153 citations

Chronic active hepatitis with hepatitis B virus DNA and antibody against e antigen in the serum

1990 • 147 citations

Prevalence and type of pre-C HBV mutants in anti-HBe positive carriers with chronic liver disease in a highly endemic area

1991 • 94 citations

A controlled trial of human lymphoblastoid interferon in chronic hepatitis B in Italy

1989 • 87 citations

Defects in the precore region of the HBV genome in patients with chronic hepatitis B after sustained seroconversion from HBeAg to anti-HBe induced spontaneously or with interferon therapy

1990 • 86 citations

Detection of precore hepatitis B virus mutants in asymptomatic HBsAg-positive family members

1994 • 78 citations

Precore Sequence Variation in Chinese Isolates of Hepatitis B Virus

1992 • 65 citations

Evidence for a base-paired region of hepatitis B virus pregenome encapsidation signal which influences the patterns of precore mutations abolishing HBe protein expression

1993 • 63 citations

Absence of hepatitis B virus precore mutants in patients with chronic hepatitis B responding to interferon-α

1992 • 30 citations