Allosteric Modulation of Estrogen Receptor Conformation by Different Estrogen Response Elements

Molecular basis of agonism and antagonism in the oestrogen receptor

1997 • 3,285 citations

Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily

1995 • 2,390 citations

Steroid hormone receptors: Many Actors in search of a plot

1995 • 1,854 citations

The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function

1997 • 1,300 citations

The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer

1988 • 1,233 citations

TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors.

1996 • 1,095 citations

Two distinct enhancers with different cell specificities coexist in the regulatory region of polyoma

1984 • 891 citations

Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor.

1995 • 756 citations

The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: How receptors discriminate between their response elements

1993 • 745 citations

An estrogen-responsive element derived from the 5′ flanking region of the Xenopus vitellogenin A2 gene functions in transfected human cells

1986 • 729 citations

Skeletal Effects of Estrogen*

1994 • 722 citations

Mouse Estrogen Receptor β Forms Estrogen Response Element-Binding Heterodimers with Estrogen Receptor α

1997 • 610 citations

Co-activators and co-repressors in the integration of transcriptional responses

1998 • 606 citations

GRIP1, a Transcriptional Coactivator for the AF-2 Transactivation Domain of Steroid, Thyroid, Retinoid, and Vitamin D Receptors

1997 • 572 citations

Polarity-specific activities of retinoic acid receptors determined by a co-repressor

1995 • 569 citations

Allosteric effects of DNA on transcriptional regulators

1998 • 488 citations

A 13 bp palindrome is a functional estrogen responsive element and interacts specifically with estrogen receptor

1988 • 439 citations

Nuclear Receptor-Binding Sites of Coactivators Glucocorticoid Receptor Interacting Protein 1 (GRIP1) and Steroid Receptor Coactivator 1 (SRC-1): Multiple Motifs with Different Binding Specificities

1998 • 417 citations

CREB binding protein acts synergistically with steroid receptor coactivator-1 to enhance steroid receptor-dependent transcription.

1996 • 414 citations

Proliferation, hormonal responsiveness, and estrogen receptor content of MCF-7 human breast cancer cells grown in the short-term and long-term absence of estrogens.

1987 • 413 citations

The novel estrogen receptor‐β subtype: potential role in the cell‐ and promoter‐specific actions of estrogens and anti‐estrogens

1997 • 406 citations

Estrogen receptor (ER) modulators each induce distinct conformational changes in ER α and ER β

1999 • 405 citations

Human TAFII30 is present in a distinct TFIID complex and is required for transcriptional activation by the estrogen receptor

1994 • 402 citations

p300 is a component of an estrogen receptor coactivator complex.

1996 • 399 citations

Nuclear Hormone Receptor Coregulators In Action: Diversity For Shared Tasks

2000 • 377 citations

Independent modes of transcriptional activation by the p50 and p65 subunits of NF-kappa B.

1992 • 373 citations

[9] Quantitative DNase footprint titration: A method for studying protein-DNA interactions

1986 • 357 citations

Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II).

1992 • 354 citations

p300 and estrogen receptor cooperatively activate transcription via differential enhancement of initiation and reinitiation

1998 • 337 citations

The human vasopressin gene is linked to the oxytocin gene and is selectively expressed in a cultured lung cancer cell line.

1985 • 335 citations

Sequence homologies in the region preceding the transcription initiation site of the liver estrogen-responsive vitellogenin and apo-VLDLII genes

1984 • 261 citations

Transcriptional activation by the estrogen receptor requires a conformational change in the ligand binding domain.

1993 • 249 citations

Allosteric Effects of Pit-1 DNA Sites on Long-Term Repression in Cell Type Specification

2000 • 240 citations

Structure of the RXR–RAR DNA-binding complex on the retinoic acid response element DR1

2000 • 212 citations

Effects of estrogens and antiestrogens on estrogen receptor dynamics and the induction of progesterone receptor in MCF-7 human breast cancer cells.

1982 • 212 citations

Specific binding of estrogen receptor to the estrogen response element.

1989 • 199 citations

Multihormonal Regulation of the Progesterone Receptor in MCF-7 Human Breast Cancer Cells: Interrelationships among Insulin/Insulin-Like Growth Factor-I, Serum, and Estrogen*

1990 • 187 citations

Mobility Shift <scp>DNA</scp>‐Binding Assay Using Gel Electrophoresis

1996 • 167 citations

Molecular Determinants of the Estrogen Receptor-Coactivator Interface

1999 • 167 citations

Escherichia coli integration host factor bends the DNA at the ends of IS1 and in an insertion hotspot with multiple IHF binding sites.

1987 • 137 citations

Differential DNA-binding abilites of estrogen receptor occupied with two classes of antiestrogens: studies using human estrogen receptor overexpressed in mammalian cells

1991 • 128 citations

Characterization of the Estrogen-Induced pS2 Protein Secreted by the Human Breast Cancer Cell Line MCF-7*

1987 • 125 citations

Intracellular receptors use a common mechanism to interpret signaling information at response elements.

1996 • 125 citations

DNA binding-induced conformational change of the yeast transcriptional activator PRTF

1990 • 119 citations

Estrogen Response Elements Function as Allosteric Modulators of Estrogen Receptor Conformation

1998 • 110 citations

Interdomain Signaling in a Two-domain Fragment of the Human Glucocorticoid Receptor

1999 • 102 citations

The N-terminal Region of the Human Progesterone A-receptor

2000 • 90 citations

The oestrogen receptor recognizes an imperfectly palindromic response element through an alternative side-chain conformation

1995 • 89 citations

Human estrogen receptor bound to an estrogen response element bends DNA.

1993 • 85 citations

Sperm, a source of estrogen.

1995 • 84 citations

Distinct conformations of vitamin D receptor/retinoid X receptor-alpha heterodimers are specified by dinucleotide differences in the vitamin D-responsive elements of the osteocalcin and osteopontin genes.

1996 • 81 citations

The role of estrogen response elements in expression of the Xenopus laevis vitellogenin B1 gene.

1992 • 75 citations

Two distinct domains in the yeast transcription factor IID and evidence for a TATA box-induced conformational change.

1991 • 73 citations

Thyroid Hormone Response Elements Differentially Modulate the Interactions of Thyroid Hormone Receptors with Two Receptor Binding Domains in the Steroid Receptor Coactivator-1

1998 • 69 citations

Analysis of the Structural Core of the Human Estrogen Receptor Ligand Binding Domain by Selective Proteolysis/Mass Spectrometric Analysis

1995 • 68 citations

Estrogen receptor affinity and location of consensus and imperfect estrogen response elements influence transcription activation of simplified promoters.

1996 • 64 citations

Conformational transitions of the estrogen receptor monomer. Effects of estrogens, antiestrogen, and temperature.

1986 • 57 citations

Mobility Shift DNA‐Binding Assay Using Gel Electrophoresis

1988 • 44 citations

The role of estrogen response elements in expression of the Xenopus laevis vitellogenin B1 gene

1992 • 36 citations

The metabolic and cardiovascular consequences of HRT.

1995 • 34 citations

THE METABOLIC AND CARDIOVASCULAR CONSEQUENCES OF HRT

1995 • 23 citations

Clamping the TBP stirrup

1995 • 4 citations