Differential effects of pertussis toxin on insulin-stimulated phosphatidylcholine hydrolysis and glycerolipid synthesis de novo. Studies in BC3H-1 myocytes and rat adipocytes

THE FUNCTION OF CYTIDINE COENZYMES IN THE BIOSYNTHESIS OF PHOSPHOLIPIDES

1956 • 1,757 citations

Signal transduction via phosphatidylcholine cycles

1989 • 314 citations

Mechanisms of the ability of insulin to activate the glucose-transport system in rat adipocytes

1978 • 229 citations

Insulin Rapidly Increases Diacylglycerol by Activating De Novo Phosphatidic Acid Synthesis

1987 • 200 citations

Insulin increases membrane and cytosolic protein kinase C activity in BC3H-1 myocytes.

1987 • 171 citations

Insulin-stimulated diacylglycerol production results from the hydrolysis of a novel phosphatidylinositol glycan.

1987 • 166 citations

Quantitative measurement of sn-1,2-diacylglycerols

1987 • 166 citations

Sangivamycin, a nucleoside analogue, is a potent inhibitor of protein kinase C.

1988 • 148 citations

The de novo phospholipid effect of insulin is associated with increases in diacylglycerol, but not inositol phosphates or cytosolic Ca2+

1985 • 146 citations

Effects of insulin and protein synthesis inhibitors on phospholipid metabolism, diacylglycerol levels, and pyruvate dehydrogenase activity in BC3H-1 cultured myocytes.

1984 • 136 citations

Pertussis toxin treatment attenuates some effects of insulin in BC3H-1 murine myocytes.

1988 • 107 citations

Effects of Insulin on Diacylglycerol–Protein Kinase C Signaling in Rat Diaphragm and Soleus Muscles and Relationship to Glucose Transport

1990 • 96 citations

Insulin, oxytocin, and vasopressin stimulate protein kinase C activity in adipocyte plasma membranes.

1990 • 92 citations

Insulin and glucose modulate protein kinase C activity in rat adipocytes

1988 • 80 citations

Mechanisms whereby insulin increases diacylglycerol in BC3H-1 myocytes

1988 • 69 citations

Insulin stimulates the translocation of protein kinase C in rat adipocytes

1989 • 68 citations

Insulin activates glycerol-3-phosphate acyltransferase (de novo phosphatidic acid synthesis) through a phospholipid-derived mediator. Apparent involvement of Gi.alpha. and activation of a phospholipase C

1990 • 66 citations

Insulin and oxytocin effects on phosphoinositide metabolism in adipocytes.

1988 • 58 citations

Insulin increases the synthesis of phospholipid and diacylglycerol and protein kinase C activity in rat hepatocytes

1990 • 51 citations

Glucose‐induced synthesis of diacylglycerol de novo is associated with translocation (activation) of protein kinase C in rat adipocytes

1989 • 47 citations

Protein kinase C inhibitors block insulin and PMA-stimulated hexose transport in isolated rat adipocytes and BC3H-1 myocytes

1990 • 43 citations

Turnover of phospholipid fatty acyl chains in cultured neuroblastoma cells: involvement of deacylation-reacylation and de novo synthesis in plasma membranes

1986 • 41 citations

Effects of insulin and phorbol esters on diacylglycerol generation and synthesis and hydrolysis of phosphatidylcholine in BC3H-1 myocytes

1988 • 34 citations

Insulin-dependent alterations of phorbol ester binding to adipocyte subcellular constituents. Evidence for the involvement of protein kinase C in insulin action

1987 • 31 citations

Effects of insulin, pertussis toxin and cholera toxin on protein synthesis and diacylglycerol production in 3T3 fibroblasts: Evidence for a G-protein mediated activation of phospholipase C in the insulin signal mechanism

1987 • 26 citations

Insulin provokes co-ordinated increases in the synthesis of phosphatidylinositol, phosphatidylinositol phosphates and the phosphatidylinositol–glycan in BC3H-1 myocytes

1988 • 26 citations

Protein kinase C activation patterns are determined by methodological variations. Studies of insulin action in BC3H-1 myocytes and rat adipose tissue

1990 • 23 citations

Effects of starvation and different culture conditions on the phospholipid content of isolated pancreatic islets

1984 • 22 citations

Signal transduction in EJ‐H‐ras‐transformed cells: De novo synthesis of diacylglycerol and subversion of agonist‐stimulated inositol lipid metabolism

1989 • 19 citations

Biochemical and antigenic characterization of CD45 polypeptides expressed on plasma membrane and internal granules of human neutrophils

1989 • 19 citations

Stimulation of rat liver glycerol-3-phosphate acyltransferase activity by acid- and heat-stable low-molecular-weight substances from skeletal muscle of rats treated with insulin

1987 • 16 citations

Hormonal regulation of phosphatidylcholine synthesis by reversible modulation of cytidylyltransferase.

1988 • 9 citations

Stimulation of phosphatidylcholine synthesis by insulin and ATP in isolated rat adipocyte plasma membranes

1986 • 7 citations