The role of hepatitis B virus in the development of primary hepatocellular carcinoma: Part I

HEPATOCELLULAR CARCINOMA AND HEPATITIS B VIRUS

1981 • 2,891 citations

Mutational hot spot in the p53 gene in human hepatocellular carcinomas

1991 • 1,525 citations

Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate

1982 • 1,429 citations

Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa

1991 • 1,418 citations

Hepatitis B virus.The major etiology of hepatocellular carcinoma

1988 • 1,308 citations

A "New" Antigen in Leukemia Sera

1965 • 1,302 citations

VIRUS-LIKE PARTICLES IN SERUM OF PATIENTS WITH AUSTRALIA-ANTIGEN-ASSOCIATED HEPATITIS

1970 • 1,003 citations

Nucleotide sequence of the hepatitis B virus genome (subtype ayw) cloned in E. coli

1979 • 992 citations

Primary structural comparison of RNA-dependent polymerases from plant, animal and bacterial viruses

1984 • 830 citations

Large surface proteins of hepatitis B virus containing the pre-s sequence

1984 • 812 citations

An antigen detected in the blood during the incubation period of serum hepatitis.

1968 • 786 citations

DNA Polymerase Associated with Human Hepatitis B Antigen

1973 • 741 citations

Integration of Hepatitis B Virus DNA into the Genome of Liver Cells in Chronic Liver Disease and Hepatocellular Carcinoma

1981 • 715 citations

A virus similar to human hepatitis B virus associated with hepatitis and hepatoma in woodchucks.

1978 • 657 citations

A Serum Antigen (Australia Antigen) in Down's Syndrome, Leukemia, and Hepatitis

1967 • 650 citations

Identification of a rat liver nuclear protein that binds to the enhancer core element of three animal viruses.

1987 • 631 citations

The development of cirrhosis in patients with chronic type B hepatitis: A prospective study

1988 • 621 citations

Presence of integrated hepatitis B virus DNA sequences in cellular DNA of human hepatocellular carcinoma

1980 • 610 citations

Base sequence studies of 300 nucleotide renatured repeated human DNA clones

1981 • 605 citations

Retroviral Recombination and Reverse Transcription

1990 • 596 citations

Hepatocellular carcinoma and the hepatitis B virus: evidence for a causal association.

1978 • 588 citations

Hepatitis B virus genes and their expression in E. coli

1979 • 584 citations

Virus of Pekin ducks with structural and biological relatedness to human hepatitis B virus

1980 • 506 citations

Sequence homology between retroviral reverse transcriptase and putative polymerases of hepatitis B virus and cauliflower mosaic virus

1983 • 464 citations

Tbe complete nudeotide sequences of the cloned hepatitis B vims DNA; subtype adr and adw

1983 • 426 citations

Particles associated with Australia Antigen in the Sera of Patients with Leukaemia, Down's Syndrome and Hepatitis

1968 • 415 citations

Abnormal structure and expression of p53 gene in human hepatocellular carcinoma.

1990 • 413 citations

Hepatitis B virus DNA contains a glucocorticoid-responsive element.

1986 • 400 citations

ASSOCIATION OF ANDROGENIC-ANABOLIC STEROID THERAPY WITH DEVELOPMENT OF HEPATOCELLULAR CARCINOMA

1972 • 374 citations

A virus in Beechey ground squirrels that is related to hepatitis B virus of humans.

1980 • 367 citations

Structural and pathological effects of synthesis of hepatitis B virus large envelope polypeptide in transgenic mice.

1987 • 353 citations

State of hepatitis B virus DNA in hepatocytes of patients with hepatitis B surface antigen-positive and -negative liver diseases.

1981 • 351 citations

Hepatitis B virus, aflatoxins, and hepatocellular carcinoma in Southern Guangxi, China

1990 • 325 citations

trans-activation of viral enhancers by the hepatitis B virus X protein

1988 • 316 citations

Replication strategy of human hepatitis B virus

1987 • 314 citations

Genome of hepatitis B virus: restriction enzyme cleavage and structure of DNA extracted from Dane particles.

1975 • 309 citations

Cloning and structural analyses of hepatitis B virus DNAs, subtypeadr

1983 • 309 citations

Nucleotide sequence of a cloned duck hepatitis B virus genome: comparison with woodchuck and human hepatitis B virus sequences

1984 • 299 citations

Nucleotide sequence of a cloned woodchuck hepatitis virus genome: comparison with the hepatitis B virus sequence

1982 • 296 citations

Biochemical and Genetic Evidence for the Hepatitis B Virus Replication Strategy

1986 • 296 citations

A human hepatitis B viral enhancer element.

1985 • 286 citations

Transcriptional trans-activating function of hepatitis B virus

1987 • 280 citations

Hepatic adenoma and focal nodular hyperplasia: Clinical, pathologic, and radiologic features

1983 • 277 citations

THE NUCLEOTIDE SEQUENCE OF THE HEPATITIS B VIRAL GENOME AND THE IDENTIFICATION OF THE MAJOR VIRAL GENES

1980 • 277 citations

Hepatocarcinogenicity of the woodchuck hepatitis virus.

1987 • 273 citations

DNA of a Human Hepatitis B Virus Candidate

1974 • 270 citations

Relationship Between Hepatocellular Carcinoma and Cirrhosis

1984 • 264 citations

Highly preferred targets for retrovirus integration

1988 • 262 citations

CHRONIC LIVER DISEASE AND PRIMARY LIVER-CELL CANCER WITH HEPATITIS-ASSOCIATED (AUSTRALIA) ANTIGEN IN SERUM

1970 • 256 citations

Effects of Immunosuppressive Therapy on Viral Markers in Chronic Active Hepatitis B

1981 • 252 citations

Observations on Australia Antigen in Japanese

1968 • 250 citations

Signals regulating hepatitis B surface antigen transcription

1983 • 246 citations

Emergence of Malignant Lesions Within an Adenomatous Hyperplastic Nodule in a Cirrhotic Liver

1986 • 233 citations

Role of chromosome translocations in human neoplasia

1987 • 226 citations

Allelotype study of primary hepatocellular carcinoma

1991 • 223 citations

Idiopathic Hemochromatosis, an Interim Report

1980 • 221 citations

Identification of integrated hepatitis B virus DNA sequences in human hepatocellular carcinomas

1981 • 217 citations

Trans-activation of the human immunodeficiency virus long terminal repeat by the hepatitis B virus X protein.

1988 • 212 citations

Detection of hepatitis B virus DNA in mononuclear blood cells.

1984 • 206 citations

Common evolutionary origin of hepatitis B virus and retroviruses.

1986 • 204 citations

Transcriptional activation of homologous and heterologous genes by the hepatitis B virus X gene product in cells permissive for viral replication

1989 • 204 citations

The mode of hepatitis B virus DNA integration in chromosomes of human hepatocellular carcinoma.

1987 • 204 citations

Deletion in Chromosome 11p Associated with a Hepatitis B Integration Site in Hepatocellular Carcinoma

1985 • 199 citations

Complete nucleotide sequence of hepatitis B virus DNA of subtype adr and its conserved gene organization

1984 • 196 citations

The Long-Term Serological Course of Asymptomatic Hepatitis B Virus Carriers and the Development of Primary Hepatocellular Carcinoma

1985 • 196 citations

Non-A, Non-B Hepatitis: Evolving Epidemiologic and Clinical Perspective

1986 • 189 citations

Isolation and characterization of a hepatitis B virus endemic in herons

1988 • 187 citations

Hepatitis B Virus Infection in Cultured Human Lymphoblastoid Cells

1983 • 182 citations

Cirrhosis and hepatoma in alcoholics.

1966 • 171 citations

A Liver-Specific Enhancer in the Core Promoter Region of Human Hepatitis B Virus

1989 • 168 citations

The glucocorticoid receptor recognizes a specific nucleotide sequence in hepatitis B virus DNA causing increased activity of the HBV enhancer

1988 • 167 citations

Hepatitis B virus transcription in the infected liver.

1984 • 167 citations

Analysis of processing and polyadenylation signals of the hepatitis B virus surface antigen gene by using simian virus 40-hepatitis B virus chimeric plasmids.

1983 • 164 citations

State of hepatitis B viral DNA in a human hepatoma cell line

1980 • 164 citations

Nucleotide Sequence of a Cloned Hepatitis B Virus Genome, Subtype ayr: Comparison with Genomes of the Other Three Subtypes

1986 • 163 citations

Integration of hepatitis B virus DNA and its implications for hepatocarcinogenesis.

1990 • 162 citations

Deletions in human chromosome arms 11p and 13q in primary hepatocellular carcinomas

1988 • 161 citations

Hepatitis B Virus DNA in Mononuclear Cells and Analysis of Cell Subsets for the Presence of Replicative Intermediates of Viral DNA

1986 • 161 citations

The HBV X-ORF encodes a transactivator: a potential factor in viral hepatocarcinogenesis.

1988 • 161 citations

DNA Polymerase in the Core of the Human Hepatitis B Virus Candidate

1974 • 156 citations

Specific hepatitis B virus integration in hepatocellular carcinoma DNA through a viral 11-base-pair direct repeat.

1984 • 156 citations

Hepatitis B virus integration site in hepatocellular carcinoma at chromosome 17;18 translocation.

1986 • 155 citations

Nucleotide sequence of an infectious molecularly cloned genome of ground squirrel hepatitis virus

1984 • 155 citations

Subtype ayw variant of hepatitis B virus

1985 • 154 citations

Comparative sequence analysis of duck and human hepatitis B virus genomes

1985 • 153 citations

Woodchuck hepatitis and hepatocellular carcinoma: Correlation of histologic with virologic observations

1981 • 152 citations

Cancer of the liver and cirrhosis in trans-Saharan Africa and the United States of America

1960 • 149 citations

A prospective study on the development of hepatocellular carcinoma from liver cirrhosis with persistent hepatitis B virus infection

1980 • 148 citations

Hepatocellular carcinoma in woodchuck hepatitis virus-infected woodchucks: Presence of viral DNA in tumor tissue from chronic carriers and animals serologically recovered from acute infections

1989 • 147 citations

HOST RESPONSES TO HEPATITIS-B INFECTION IN PATIENTS WITH PRIMARY HEPATIC CARCINOMA AND THEIR FAMILIES

1976 • 145 citations

trans-Activation of viral enhancers including long terminal repeat of the human immunodeficiency virus by the hepatitis B virus X protein

1989 • 145 citations

Rearrangement and enhanced expression of c-myc in hepatocellular carcinoma of hepatitis virus infected woodchucks

1986 • 139 citations

Hepatitis B virus X gene can transactivate heterologous viral sequences.

1989 • 137 citations

Light Microscopic Localization of Hepatitis B Virus Antigens in the Human Pancreas

1981 • 137 citations

CIRRHOSIS AND MALIGNANT HEPATOMA IN α₁‐ANTITRYPSIN DEFICIENCY

1974 • 136 citations

Hepatitis B surface antigen gene expression is regulated by sex steroids and glucocorticoids in transgenic mice.

1987 • 135 citations

Hepatitis B virus integration event in human chromosome 17p near the p53 gene identifies the region of the chromosome commonly deleted in virus-positive hepatocellular carcinomas.

1991 • 128 citations

Hepatocellular carcinoma in ground squirrels persistently infected with ground squirrel hepatitis virus.

1986 • 126 citations

Hepatocellular carcinoma after non-A, non-B posttransfusion hepatitis.

1984 • 125 citations

The Complete Nucleotide Sequence of the Genome of a Hepatitis B Virus Isolated from a Naturally Infected Chimpanzee

1988 • 125 citations

Liver-specific expression of hepatitis B virus is determined by the combined action of the core gene promoter and the enhancer

1989 • 125 citations

Cloning and structural analysis of integrated woodchuck hepatitis virus sequences from hepatocellular carcinomas of woodchucks

1982 • 125 citations

Integration of hepatitis B virus DNA: Evidence for integration in the single-stranded gap

1983 • 123 citations

Mapping the major transcripts of ground squirrel hepatitis virus: the presumptive template for reverse transcriptase is terminally redundant

1985 • 122 citations

Protein covalently bound to minus-strand DNA intermediates of duck hepatitis B virus

1983 • 121 citations

Transcription of hepatitis B virus by RNA polymerase II.

1983 • 120 citations

Hepadnavirus infection of peripheral blood lymphocytes in vivo: woodchuck and chimpanzee models of viral hepatitis

1986 • 120 citations

Mechanisms of Liver Cell Injury in Acute and Chronic Hepatitis B

1984 • 120 citations

Primary Hepatocellular Carcinoma After Chronic Non-A, Non-B Post-Transfusion Hepatitis

1984 • 119 citations

Hepatocellular carcinoma in the U.S.A., etiologic considerations. Localization of hepatitis B antigens.

1979 • 118 citations

Multiple integration site of hepatitis B virus DNA in hepatocellular carcinoma and chronic active hepatitis tissues from children

1987 • 118 citations

Hepatitis B virus (HBV) promoters are regulated by the HBV enhancer in a tissue-specific manner

1989 • 115 citations

The genome of hepatitis B virus contains a second enhancer: cooperation of two elements within this enhancer is required for its function

1990 • 114 citations

Risk factors for hepatocellular carcinoma in italy. Male sex, hepatitis b virus, non-a non-B infection, and alcohol

1988 • 113 citations

Hepatitis B virus DNA Sequences in Lymphoid Cells from Patients with AIDS and AIDS-Related Complex

1985 • 113 citations

Chromosomal translocation and inverted duplication associated with integrated hepatitis B virus in hepatocellular carcinomas

1987 • 113 citations

Extrahepatic manifestations of viral hepatitis

1975 • 113 citations

Sequence of hepatitis B virus DNA incorporated into the genome of a human hepatoma cell line

1985 • 113 citations

Synthesis of hepatitis B surface antigen in mammalian cells: expression of the entire gene and the coding region

1983 • 113 citations

Compact organization of the hepatitis B virus genome

1989 • 112 citations

Hepatitis B virus integration in hepatocellular carcinoma DNA: duplication of cellular flanking sequences at the integration site.

1985 • 112 citations

Hepatitis B Virus DNA in Liver and White Blood Cells of Patients with Hepatoma

1983 • 109 citations

Cellular factors that interact with the hepatitis B virus enhancer.

1989 • 108 citations

Detection of Hepatitis B Virus-specific DNA in the Genomes of Human Hepatocellular Carcinoma and Liver Cirrhosis Tissues

1981 • 108 citations

Hepatocellular carcinoma in the U.S.A., etiologic considerations

1979 • 106 citations

Identification of a promoter element located upstream from the hepatitis B virus X gene.

1987 • 103 citations

Detection of Hepatitis B Virus DNA in Hepatocellular Carcinomas in Japan

1984 • 102 citations

Primary hepatocellular carcinoma following non-A, non-B posttransfusion hepatitis

1983 • 102 citations

The human hepatitis B virus enhancer requires trans-acting cellular factor(s) for activity.

1986 • 99 citations

Topoisomerase I-mediated integration of hepadnavirus DNA in vitro

1991 • 99 citations

Evidence of extrachromosomal forms of hepatitis B viral DNA in a bone marrow culture obtained from a patient recently infected with hepatitis B virus.

1984 • 98 citations

Transcription of the hepatitis B surface antigen gene in cultured murine cells initiates within the presurface region

1984 • 96 citations

A novel expression selection approach allows precise mapping of the hepatitis B virus enhancer

1985 • 95 citations

Transcription of woodchuck hepatitis virus in the chronically infected liver.

1985 • 95 citations

Aflatoxin exposure measured by urinary excretion of aflatoxin B1-guanine adduct and hepatitis B virus infection in areas with different liver cancer incidence in Kenya.

1987 • 94 citations

Mapping of the cohesive overlap of duck hepatitis B virus DNA and of the site of initiation of reverse transcription

1984 • 91 citations

Subclinical hepatocellular carcinoma

1986 • 91 citations

A new enhancer element, ENII, identified in the X gene of hepatitis B virus

1990 • 88 citations

Hepatitis B surface antigen in pancreatic and biliary secretions

1980 • 88 citations

Tight clustering of human hepatitis B virus integration sites in hepatomas near a triple-stranded region

1987 • 86 citations

High-Frequency Transfection and Cytopathology of the Hepatitis B Virus Core Antigen Gene in Human Cells

1983 • 85 citations

Viral hepatitis: a pathologic spectrum

1975 • 85 citations

Taxonomic Classification of Human Hepatitis B Virus

1986 • 83 citations

Features of two hepatitis B virus (HBV) DNA integrations suggest mechanisms of HBV integration

1989 • 80 citations

Increasing incidence of hepatocellular carcinoma possibly associated with non-A, non-B hepatitis in Japan, disclosed by hepatitis B virus DNA analysis of surgically resected cases.

1988 • 78 citations

Activation of class I major histocompatibility complex gene expression by hepatitis B virus

1990 • 78 citations

Transcriptional activation and repression by cellular DNA-binding protein C/EBP

1990 • 72 citations

Duck hepatitis B virus DNA in liver and serum of Chinese ducks: integration of viral DNA in a hepatocellular carcinoma.

1985 • 72 citations

Lymphoid cells in the spleens of woodchuck hepatitis virus-infected woodchucks are a site of active viral replication

1987 • 71 citations

Functional Organization of the Hepatitis Β Virus Enhancer

1990 • 70 citations

Extrachromosomal sequences of hepatitis B virus DNA in peripheral blood mononuclear cells of acquired immune deficiency syndrome patients.

1986 • 70 citations

Functional analysis of a liver-specific enhancer of the hepatitis B virus.

1991 • 69 citations

A pattern of partially homologous recombination in mouse L cells.

1984 • 68 citations

Co-amplification of integrated hepatitis B virus DNA and transforming gene hst-1 in a hepatocellular carcinoma.

1988 • 65 citations

Oncogenic potential of the hepatitis B virus.

1983 • 64 citations

Delayed Sexual Maturation Induced by Daily Melatonin Administration Eliminates the LH Response to Naloxone despite Normal Responsiveness to GnRH in Juvenile Male Rats

1988 • 62 citations

Cloning and structural analysis of integrated woodchuck hepatitis virus sequences from a chronically infected liver

1984 • 61 citations

The duck hepatitis B virus P-gene codes for protein strongly associated with the 5′-end of the viral dna minus strand

1988 • 60 citations

Complete nucleotide sequence of a molecular clone of woodchuck hepatitis virus that is infectious in the natural host.

1989 • 59 citations

Woodchuck hepatitis virus is a more efficient oncogenic agent than ground squirrel hepatitis virus in a common host

1991 • 57 citations

A single element within the hepatitis B virus enhancer binds multiple proteins and responds to multiple stimuli

1990 • 55 citations

Interactions between nuclear factors and the hepatitis B virus enhancer

1989 • 52 citations

GENETIC VARIATION AMONG HEPATITIS B AND RELATED VIRUSES*

1980 • 51 citations

Integration of hepatitis B virus DNA in chromosome-specific satellite sequences

1986 • 51 citations

Hepatocellular carcinoma in primary biliary cirrhosis: An autopsy study

1990 • 51 citations

Lymphocyte cytotoxicity to autologous hepatocytes in chronic hepatitis B virus infection

1982 • 50 citations

Epidemiology and Early Diagnosis of Primary Liver Cancer in China

1986 • 50 citations

Isolation of a fraction from cauliflower mosaic virus-infected protoplasts which is active in the synthesis of (+) and (−) strand viral DNA and reverse transcription of primed RNA templates

1985 • 50 citations

Differential regulation of the hepatitis B virus surface gene promoters by a second viral enhancer.

1990 • 44 citations

Major polypeptide of duck hepatitis B surface antigen particles

1983 • 42 citations

The hepatitis B virus-associated reverse transcriptase is encoded by the viral pol gene

1989 • 42 citations

Carcinogenesis and prevention strategy of liver cancer in areas of prevalence

1984 • 40 citations

Functional organization of the hepatitis B virus enhancer.

1990 • 40 citations

Hepatitis B Viral DNA in Infected Human Liver and in Hepatocellular Carcinoma

1985 • 39 citations

Individual Morphological Variations Seen in Australia Antigen Positive Sera

1972 • 38 citations

Microdeletion associated with the integration process of hepatitis B virus DNA

1988 • 37 citations

Histochemical and immunohistochemical detection of putative preneoplastic liver foci in women after long-term use of oral contraceptives

1986 • 33 citations

Oral contraceptives and hepatocellular carcinoma

1982 • 33 citations

Liver cell dysplasia and hepatocellular carcinoma in non-A, non-B hepatitis.

1987 • 32 citations

Integration of hepatitis B virus: analysis of unoccupied sites

1987 • 31 citations

Tree squirrel hepatitis B virus: antigenic and structural characterization.

1986 • 29 citations

A prospective cohort study of hepatitis B surface antigen carriers in a working population.

1984 • 26 citations

Experimental WHV infection of woodchucks: An animal model of hepadnavirus-induced liver cancer

1990 • 24 citations

Free and integrated forms of hepatitis B virus DNA in human hepatocellular carcinoma cells (PLC/342) propagated in nude mice

1987 • 21 citations

Integrated structures of duck hepatitis B virus DNA in hepatocellular carcinoma

1988 • 21 citations

Prevention of liver cancer

1997 • 20 citations

A Comparison of the Molecular Structure of Integrated Hepatitis B Virus Genomes in Hepatocellular Carcinoma Cells and Hepatocytes Derived From the Same Patient

1990 • 19 citations

Hepatocellular Carcinoma

1982 • 17 citations

Complete nucleotide sequence of hepatitis B virus

1990 • 17 citations

EPIDEMIOLOGY OF HEPATITIS B AND PRIMARY HEPATIC CARCINOMA

1975 • 17 citations

Hepatocellular carcinoma in Alaska Eskimos: epidemiology, clinical features, and early detection.

1990 • 10 citations

Detection of hepatitis B virus DNA sequences in human hepatocellular carcinoma in an integrated form.

1981 • 10 citations

The nucleotide sequence of surface antigen gene of hepatitis B virus subtype adr.

1984 • 7 citations

New model systems for hepatitis B virus research.

1988 • 6 citations

In Vitro Gluten Sensitivity

1981 • 4 citations

Long-term follow-up of mild chronic active hepatitis.

1987 • 3 citations

Chromosome accommodation to integration of foreign DNA

1987 • 3 citations

Liver diseases associated with hepadnavirus infection. A study in duck model.

1989 • 2 citations

Determination of the complete nucleotide sequence of HBV adr NC-1 DNA.

1989 • 2 citations