Structure/activity relationship of leukotriene B₄ and its structural analogues in chemotactic, lysosomal‐enzyme release and receptor‐binding assays

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes

1980 • 2,099 citations

Leukotriene C: a slow-reacting substance from murine mastocytoma cells.

1979 • 992 citations

Enhanced Synthesis of Leukotriene B4 by Colonic Mucosa in Inflammatory Bowel Disease

1984 • 749 citations

Metabolism of arachidonic acid in polymorphonuclear leukocytes. Structural analysis of novel hydroxylated compounds.

1979 • 556 citations

The human PMN leukocyte chemotactic activity of complex hydroxy-eicosatetraenoic acids (HETEs).

1980 • 518 citations

The immunologic release of constituents from neutrophil leukocytes. I. The role of antibody and complement on nonphagocytosable surfaces or phagocytosable particles.

1971 • 513 citations

Arachidonic acid metabolism in polymorphonuclear leukocytes: unstable intermediate in formation of dihydroxy acids.

1979 • 465 citations

Slow reacting substances of anaphylaxis: Identification of leukotrienes C-1 and D from human and rat sources

1980 • 433 citations

Stereospecific total synthesis of a "slow reacting substance" of anaphylaxis, leukotriene C-1

1980 • 369 citations

Lipoxygenation of arachidonic acid as a source of polymorphonuclear leukocyte chemotactic factors in synovial fluid and tissue in rheumatoid arthritis and spondyloarthritis.

1980 • 350 citations

The Immunologic Release of Constituents from Neutrophil Leukocytes

1971 • 319 citations

Characterization and biologic properties of 5,12-dihydroxy derivatives of eicosapentaenoic acid, including leukotriene B5 and the double lipoxygenase product.

1984 • 304 citations

Identification of the C(6)-S-conjugate of leukotriene a with cysteine as a naturally occurring slow reacting substance of anaphylaxis (SRS-A). Importance of the 11-cis-geometry for biological activity

1980 • 267 citations

Release of leukotrienes in patients with bronchial asthma

1988 • 259 citations

The Release of Leukotriene B4-like Material in Biologically Active Amounts from the Lesional Skin of patients with Psoriasis

1984 • 220 citations

Heterogeneity of human polymorphonuclear leukocyte receptors for leukotriene B4. Identification of a subset of high affinity receptors that transduce the chemotactic response.

1984 • 218 citations

Leukotriene B. Total synthesis and assignment of stereochemistry

1980 • 201 citations

LEUKOTRIENE B4, AN INFLAMMATORY MEDIATOR IN GOUT

1982 • 193 citations

Pertussis toxin inhibition of chemotactic factor-induced calcium mobilization and function in human polymorphonuclear leukocytes.

1985 • 192 citations

Purification of arachidonate 5-lipoxygenase from porcine leukocytes and its reactivity with hydroperoxyeicosatetraenoic acids.

1986 • 191 citations

Identification and partial characterization of an exercise-induced neutrophil chemotactic factor in bronchial asthma.

1982 • 188 citations

Stimulation of human leukocyte degranulation by leukotriene B₄ and its ω‐oxidized metabolites

1981 • 182 citations

Characterization of leukotriene A4 synthase from murine mast cells: evidence for its identity to arachidonate 5-lipoxygenase.

1986 • 171 citations

Leukotriene a: Stereochemistry and enzymatic conversion to leukotriene B

1980 • 162 citations

Immunoregulation by leukotrienes and other lipoxygenase metabolites

1985 • 147 citations

Total synthesis of leukotriene B5

1983 • 124 citations

Characterization of the secretory activity of leukotriene B4 toward rabbit neutrophils.

1982 • 122 citations

The total synthesis of 12-HETE (12-hydroxyeicosatetraenoic acid) and 12,20-diHETE

1986 • 99 citations

Purification, characterization, and structural properties of a single protein from rat basophilic leukemia (RBL-1) cells possessing 5-lipoxygenase and leukotriene A4 synthetase activities.

1986 • 97 citations

Characterization of leukotriene B3: comparison of its biological activities with leukotriene B4 and leukotriene B5 in complement receptor enhancement, lysozyme release and chemotaxis of human neutrophils

1988 • 94 citations

Leukotriene B4 binding to human neutrophils

1984 • 93 citations

Isomers of leukotriene B4 possess different biological potencies

1981 • 93 citations

ONO-4057, a novel, orally active leukotriene B4 antagonist: Effects on LTB4-induced neutrophil functions

1992 • 83 citations

Contrasting in vitro lymphocyte chemotactic activity of the hydroxyl enantiomers of 12‐hydroxy‐5,8,10,14‐eicosatetraenoic acid

1988 • 77 citations

7-[3-(4-Acetyl-3-methoxy-2-propylphenoxy)propoxy]-3,4-dihydro-8-propyl-2H-1-benzopyran-2-carboxylic acid: an orally active selective leukotriene B4 receptor antagonist

1989 • 53 citations

Synthesis of novel antagonists of leukotriene B4

1988 • 47 citations

SC-41930: An inhibitor of leukotriene B4-stimulated human neutrophil functions

1989 • 41 citations

Inhibition of leukotriene B4-induced neutrophil degranulation by leukotriene B4-dimethylamide

1982 • 39 citations

Effects of Synthetic Leukotrienes on Local Blood Flow and Vascular Permeability in Porcine Skin

1985 • 36 citations

Stereochemistry, total synthesis, and biological activity of 14,15-dihydroxy-5,8,10,12-eicosatetraenoic acid.

1984 • 30 citations

Benzophenone dicarboxylic acid antagonists of leukotriene B4. 2. Structure-activity relationships of the lipophilic side chain

1990 • 30 citations

Leukotriene B3, leukotriene B4 and leukotriene B5; Binding to leukotriene B4 receptors on rat and human leukocyte membranes

1986 • 26 citations

Biochemical and Cellular Characteristics of the Regulation of Human Leukocyte Function by Lipoxygenase Products of Arachidonic Acid

1984 • 26 citations

Pharmacological profiles of a potential LTB4-antagonist, SM-9064

1986 • 25 citations

Analogs of leukotriene B4: Effects of modification of the hydroxyl groups on leukocyte aggregation and binding to leukocyte leukotriene B4 receptors

1987 • 21 citations

Synthesis of Leukotriene B₃

1985 • 19 citations

Syntheses of the Leukotrienes C₅, D₅, and E₅

1984 • 11 citations

Synthese von Leukotrien E₃

1983 • 7 citations