Immunoregulation by leukotrienes and other lipoxygenase metabolites

Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes

1980 • 2,099 citations

Transformation of arachidonic acid by rabbit polymorphonuclear leukocytes. Formation of a novel dihydroxyeicosatetraenoic acid.

1979 • 652 citations

Transformation of arachidonic acid and homo-gamma-linolenic acid by rabbit polymorphonuclear leukocytes. Monohydroxy acids from novel lipoxygenases

1976 • 638 citations

Local Effects of Synthetic Leukotrienes (LTC4, LTD4, and LTB4) in Human Skin

1983 • 585 citations

Metabolism of arachidonic acid in polymorphonuclear leukocytes. Structural analysis of novel hydroxylated compounds.

1979 • 556 citations

The human PMN leukocyte chemotactic activity of complex hydroxy-eicosatetraenoic acids (HETEs).

1980 • 518 citations

Chemokinetic activity of arachidonic acid lipoxygenase products on leuocyctes of different species

1980 • 399 citations

Biogenesis of chemotactic molecules by the arachidonate lipoxygenase system of platelets

1975 • 393 citations

Lipoxygenation of arachidonic acid as a source of polymorphonuclear leukocyte chemotactic factors in synovial fluid and tissue in rheumatoid arthritis and spondyloarthritis.

1980 • 350 citations

Leukotrienes and other Lipoxygenase Products

1983 • 319 citations

Identification and biological activity of novel ω‐oxidized metabolites of leukotriene B₄ from human leukocytes

1981 • 313 citations

Leukotriene B: a potential mediator of inflammation

1980 • 303 citations

Human alveolar macrophages produce leukotriene B4.

1982 • 278 citations

Specific binding of leukotriene B4 to receptors on human polymorphonuclear leukocytes.

1982 • 263 citations

Generation of unique mono-hydroxy-eicosatetraenoic acids from arachidonic acid by human neutrophils.

1979 • 258 citations

Introduction of a nomenclature: Leukotrienes

1979 • 257 citations

LEUKOTRIENE B₄: A MEDIATOR OF VASCULAR PERMEABILITY

1981 • 247 citations

Leukotriene B4: An inflammatory mediator In vivo

1981 • 213 citations

LEUKOTRIENE B4, AN INFLAMMATORY MEDIATOR IN GOUT

1982 • 193 citations

Arachidonic acid 15-lipoxygenase products from human eosinophils.

1982 • 193 citations

Slow Reacting Substances (SRSs): The structure identification of SRSs from rat basophil leukaemia (RBL-1) cells

1980 • 192 citations

Novel structural determinants of the human neutrophil chemotactic activity of leukotriene B.

1981 • 189 citations

Arachidonic acid metabolism among human mononuclear leukocytes. Lipoxygenase-related pathways.

1984 • 184 citations

Leukotriene C₄and D₄in Neonates with Hypoxemia and Pulmonary Hypertension

1983 • 176 citations

Leukotriene B4 induces human suppressor lymphocytes

1982 • 175 citations

Poliovirus increases phosphatidylcholine biosynthesis in HeLa cells by stimulation of the rate-limiting reaction catalyzed by CTP: phosphocholine cytidylyltransferase.

1980 • 174 citations

Leukotriene a: Stereochemistry and enzymatic conversion to leukotriene B

1980 • 162 citations

Leukotriene B4 augments human natural cytotoxic cell activity

1983 • 155 citations

Leukotrienes and other lipoxygenase products

1986 • 149 citations

Effect of lipoxygenase metabolites of arachidonic acid on proliferation of human T cells and T cell subsets.

1985 • 147 citations

The influence of lipoxygenase inhibitors on the in vitro production of human leukocytic pyrogen and lymphocyte activating factor (interleukin-1)

1984 • 129 citations

THE INFLAMMATORY EFFECTS OF HYDROPEROXY AND HYDROXY ACID PRODUCTS OF ARACHIDONATE LIPOXYGENASE IN RABBIT SKIN

1981 • 128 citations

Enzymatic assembly of slow reacting substance

1980 • 122 citations

Characterization of the secretory activity of leukotriene B4 toward rabbit neutrophils.

1982 • 122 citations

Leukotriene B₄ — a stereospecific stimulator for release of lysosomal enzymes from neutrophils

1981 • 122 citations

Leukotrienes: positive signals for regulation of gamma-interferon production.

1984 • 118 citations

Specific suppression of human T lymphocyte function by leukotriene B4.

1983 • 113 citations

Regulation of T-lymphocyte mitogenesis by the leukocyte product 15-hydroxy-eicosatetraenoic acid (15-HETE)

1982 • 109 citations

Differential effects of leukotriene B4 on T4+ and T8+ lymphocyte phenotype and immunoregulatory functions.

1985 • 107 citations

IDENTIFICATION OF LEUKOTRIENES D AND B IN SPUTUM FROM CYSTIC FIBROSIS PATIENTS

1981 • 95 citations

12-L-hydroxy-5,8,10,14-eicosatetraenoic acid, a chemotactic fatty acid, is incorporated into neutrophil phospholipids and triglyceride

1979 • 92 citations

Immunopathogenetic roles of leukotrienes in human diseases

1984 • 79 citations

Control of polyclonal immunoglobulin production from human lymphocytes by leukotrienes; leukotriene B4 induces an OKT8(+), radiosensitive suppressor cell from resting, human OKT8(-) T cells.

1984 • 72 citations

Human monocytes synthesize eicosanoids from T lymphocyte-derived arachidonic acid

1982 • 70 citations

Cellular regulatory role of leukotriene B₄: Its effects on cation homeostasis in rabbit neutrophils

1981 • 61 citations

Leukotriene B4 biosynthesis by alveolar macrophages

1982 • 61 citations

Detection of leukotriene A₄ as an intermediate in the biosynthesis of leukotrienes C₄ and D₄

1980 • 60 citations

The conversion of leukotriene C4 to isomers of leukotriene B4 by human eosinophil peroxidase

1982 • 57 citations

Increased arachidonic acid content in platelet phospholipids from diabetic patients

1983 • 55 citations

Immunosuppressive properties of leukotriene D4 and E4invitro

1982 • 53 citations

Enhancement of neutrophil- and eosinophil-mediated complement-dependent killing of schistosomula of Schistosoma mansoni in vitro by leukotriene B4.

1983 • 53 citations

Human natural killer cell activity is reversibly inhibited by antagonists of lipoxygenation.

1983 • 53 citations

Cyclic nucleotides in mitogen-induced lymphocyte proliferation

1982 • 53 citations

C5a-induced tracheal contraction: effect of an SRS-A antagonist and inhibitors of arachidonate metabolism.

1981 • 50 citations

Nonsteroidal anti-inflammatory drugs stimulate 15-lipoxygenase/leukotriene pathway in human polymorphonuclear leukocytes

1984 • 43 citations

Lipoxygenase-derived products of arachidonic acid mediate stimulation of hexose uptake in human polymorphonuclear leukocytes

1981 • 41 citations

Thymocyte cyclic AMP and cyclic GMP response to treatment with metabolites issued from the lipoxygenase pathway.

1985 • 38 citations

Human natural cytotoxic cell activity: Enhancement by leukotrienes (LT) A4, B4 and D4, but not by stereoisomers of LTB4 or HETES

1984 • 38 citations

Mechanisms underlying inflammatory edema: the importance of synergism between prostaglandins, leukotrienes, and complement-derived peptides.

1983 • 38 citations

NEUTROPHIL POLYMORPHONUCLEARS, MEDIATORS AND THE PATHOGENESIS OF PSORIASIS

1983 • 34 citations

Leukotriene involvement in pathologic processes

1984 • 34 citations

Osmoreceptors or sodium receptors: an investigation into ADH release in the rhesus monkey.

1980 • 32 citations

Modulation of lymphocyte activation. I. Inhibition by an oxidation product of arachidonic acid.

1980 • 31 citations

Leukotrienes A₄ and B₄ stimulate the formation of cyclic amp in human leukocytes

1982 • 29 citations

Effects of 15‐hydroperoxyeicosatetraenoic acid on human lymphocyte sheep erythrocyte rosette formation and response to concanavalin A associated with HLA system

1982 • 25 citations

Immunosuppression induced in vivo by 15 hydroxyeicosatetoic acid (15 HETE)

1984 • 21 citations

Modulation of Fcγ receptors on T cells and monocytes by 15 hydroperoxyeicosatetranoic acid

1984 • 16 citations

The stoichiometry of the Ca2+ pump in human erythrocyte vesicles: Modulation by Ca2+, Mg2+ and calmodulin

1982 • 15 citations

Leukotriene C4: The major lipoxygenase metabolite of arachidonic acid in dog spleen

1981 • 7 citations

Leukotriene B4 (isomer III): biological activities of synthethic and biologically derived preparations

1981 • 6 citations

Effects of Leukotrienes on Neutrophil Migration, and on Production and Action of Lymphokines

1984 • 5 citations

Differential effects of nordihydroguaiaretic acid (NDGA) on b-cell subsets: Reversal of NDGA-induced antibody suppression by cyclic GMP is subset specific

1984 • 4 citations

Deleted Work

1955 • 0 citations