A Stable, Multi-Subunit Complex of β2Glycoprotein I

Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H).

1990 • 1,618 citations

Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor

1990 • 1,294 citations

Anticardiolipin antibodies recognize beta 2-glycoprotein I structure altered by interacting with an oxygen modified solid phase surface.

1994 • 535 citations

Pregnancy Loss in the Antiphospholipid-Antibody Syndrome — A Possible Thrombogenic Mechanism

1997 • 525 citations

beta 2-Glycoprotein I: a plasma inhibitor of the contact activation of the intrinsic blood coagulation pathway

1985 • 364 citations

Autoantibodies to phospholipid-binding plasma proteins: a new view of lupus anticoagulants and other "antiphospholipid" autoantibodies [see comments]

1994 • 364 citations

"Anticardiolipin" autoantibodies recognize beta 2-glycoprotein I in the absence of phospholipid. Importance of Ag density and bivalent binding.

1995 • 337 citations

Complete amino acid sequence of human plasma beta 2-glycoprotein I.

1984 • 326 citations

Autoantibodies to phospholipid-binding plasma proteins: a new view of lupus anticoagulants and other "antiphospholipid" autoantibodies [see comments]

1994 • 317 citations

Prothrombinase activity of human platelets is inhibited by β2-glycoprotein-I

1986 • 308 citations

Clinical manifestations of the antiphospholipid syndrome in patients with systemic lupus erythematosus associate more strongly with anti-beta 2-glycoprotein-I than with antiphospholipid antibodies.

1995 • 227 citations

Complete nucleotide and deduced amino acid sequence of human β2-glycoprotein I

1991 • 187 citations

Site-directed mutagenesis of recombinant human beta 2-glycoprotein I identifies a cluster of lysine residues that are critical for phospholipid binding and anti-cardiolipin antibody activity.

1996 • 162 citations

Imaging Globular and Filamentous Proteins in Physiological Buffer Solutions with Tapping Mode Atomic Force Microscopy

1995 • 148 citations

Amino acid sequence and location of the disulfide bonds in bovine .beta.2 glycoprotein I: the presence of five Sushi domains

1991 • 138 citations

Functional and binding studies of the roles of prothrombin and beta 2- glycoprotein I in the expression of lupus anticoagulant activity

1994 • 130 citations

Antibodies to phospholipid-free beta 2-glycoprotein-I in patients with primary antiphospholipid syndrome.

1995 • 101 citations

beta 2-Glycoprotein I modulates the anticoagulant activity of activated protein C on the phospholipid surface.

1996 • 85 citations

β2-Glycoprotein I Modulates the Anticoagulant Activity of Activated Protein C on the Phospholipid Surface

1996 • 71 citations

Changes in β2-Glycoprotein I Antigenicity Induced by Phospholipid Binding

1993 • 67 citations

Effect of the carbohydrate moiety on the secondary structure of .beta.2-glycoprotein. I. Implications for the biosynthesis and folding of glycoproteins

1990 • 60 citations

Analytical and clinical relationships between human IgG autoantibodies to beta 2 glycoprotein I and anticardiolipin antibodies.

1995 • 38 citations

Anticardiolipin and Anti-β2-GPI Are Two Distinct Populations of Autoantibodies

1996 • 34 citations

Characterization of the interaction between β2-glycoprotein i and mitochondria, platelets, liposomes and bile acids

1983 • 33 citations

Inhibitory activity of anti‐β₂‐glycoprotein I antibody on factor va degradation by activated‐protein C and its cofactor protein S

1995 • 30 citations

Binding of beta 2 glycoprotein I to activated polystyrene and its recognition by human IgG autoantibodies.

1995 • 12 citations

Binding of beta 2 glycoprotein I to activated polystyrene and its recognition by human IgG autoantibodies

1995 • 5 citations