Role of active and latent transforming growth factor β in bone formation

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

1993 • 1,941 citations

Transforming growth factor-beta in disease: the dark side of tissue repair.

1992 • 1,126 citations

TGF-β stimulation and inhibition of cell proliferation: New mechanistic insights

1990 • 992 citations

Natural inhibitor of transforming growth factor-β protects against scarring in experimental kidney disease

1992 • 984 citations

Inhibition of endothelial cell movement by pericytes and smooth muscle cells: activation of a latent transforming growth factor-beta 1-like molecule by plasmin during co-culture.

1989 • 914 citations

Betaglycan presents ligand to the TGFβ signaling receptor

1993 • 887 citations

An activated form of transforming growth factor beta is produced by cocultures of endothelial cells and pericytes.

1989 • 767 citations

Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin.

1990 • 740 citations

Latent high molecular weight complex of transforming growth factor beta 1. Purification from human platelets and structural characterization.

1988 • 648 citations

In VivoStimulation of Bone Formation by Transforming Growth Factor-β

1989 • 592 citations

Latent transforming growth factor-beta from human platelets. A high molecular weight complex containing precursor sequences.

1988 • 548 citations

Purification and characterization of two cartilage-inducing factors from bovine demineralized bone.

1985 • 503 citations

Thrombospondin causes activation of latent transforming growth factor- beta secreted by endothelial cells by a novel mechanism [published erratum appears in J Cell Biol 1993 Sep;122(5):following 1143]

1993 • 467 citations

TGF-β1 binding protein: A component of the large latent complex of TGF-β1 with multiple repeat sequences

1990 • 447 citations

Transforming Growth Factor-β in Leishmanial Infection: a Parasite Escape Mechanism

1992 • 439 citations

Latent transforming growth factor-beta in serum. A specific complex with alpha 2-macroglobulin.

1987 • 434 citations

Modulation of type beta transforming growth factor activity in bone cultures by osteotropic hormones.

1987 • 434 citations

Role of Transforming Growth Factor-Beta in Bone Remodeling

1990 • 425 citations

Pleiotropic Effects of Vitamin D on Osteoblast Gene Expression Are Related to the Proliferative and Differentiated State of the Bone Cell Phenotype: Dependency upon Basal Levels of Gene Expression, Duration of Exposure, and Bone Matrix Competency in Normal Rat Osteoblast Cultures*

1991 • 352 citations

Expression of Human Bone Morphogenetic Proteins-2 or -4 in Murine Mesenchymal Progenitor C3H10T½ Cells Induces Differentiation into Distinct Mesenchymal Cell Lineages

1993 • 340 citations

Effects of transforming growth factor β on bone nodule formation and expression of bone morphogenetic protein 2, osteocalcin, osteopontin, alkaline phosphatase, and type I collagen mRNA in long-term cultures of fetal rat calvarial osteoblasts

1994 • 328 citations

Activation of the bone-derived latent TGF beta complex by isolated osteoclasts

1989 • 281 citations

Human Transforming Growth Factor- β3: Recombinant Expression, Purification, and Biological Activities in Comparison with Transforming Growth Factors-β 1 and -β2

1989 • 280 citations

Terminal differentiation and calcification in rabbit chondrocyte cultures grown in centrifuge tubes: regulation by transforming growth factor beta and serum factors.

1988 • 261 citations

Isolation and sequence of the vitamin K-dependent protein from human bone. Undercarboxylation of the first glutamic acid residue.

1980 • 259 citations

In vivo effects of human recombinant transforming growth factor β on bone turnover in normal mice

1990 • 235 citations

Type 1 Transforming Growth Factor Beta: Amplified Expression and Secretion of Mature and Precursor Polypeptides in Chinese Hamster Ovary Cells

1987 • 224 citations

Transforming growth factor-beta and remodeling of bone.

1991 • 216 citations

Basic fibroblast growth factor-induced activation of latent transforming growth factor beta in endothelial cells: regulation of plasminogen activator activity.

1992 • 205 citations

Effects of combining transforming growth factor beta and 1,25-dihydroxyvitamin D3 on differentiation of a human osteosarcoma (MG-63).

1992 • 185 citations

Chemotactic response of osteoblastlike cells to transforming growth factorβ

1990 • 176 citations

Characterization and autoregulation of latent transforming growth factor beta (TGF beta) complexes in osteoblast-like cell lines. Production of a latent complex lacking the latent TGF beta-binding protein.

1994 • 173 citations

Type-β transforming growth factor inhibits proliferation and expression of alkaline phosphatase in murine osteoblast-like cells

1986 • 167 citations

Rapid publication TGF-β1 induces bone closure of skull defects

1991 • 164 citations

Molecular cloning of the large subunit of transforming growth factor type beta masking protein and expression of the mRNA in various rat tissues.

1990 • 162 citations

Complementary DNA Cloning of the Murine Transforming Growth Factor-β3 (TGFβ3) Precursor and the Comparative Expression of TGFβ3 and TGFβ1 Messenger RNA in Murine Embryos and Adult Tissues

1989 • 157 citations

Osteoclast synthesis and secretion and activation of latent transforming growth factor β

1994 • 152 citations

Type 1 transforming growth factor beta: amplified expression and secretion of mature and precursor polypeptides in Chinese hamster ovary cells.

1987 • 147 citations

Transforming growth factor-beta 1 stimulates chondrogenesis and inhibits osteogenesis in high density culture of periosteum-derived cells.

1993 • 141 citations

TGFβ alters growth and differentiation related gene expression in proliferating osteoblasts in vitro, preventing development of the mature bone phenotype

1994 • 139 citations

Plasminogen‐dependent activation of latent transforming growth factor beta (TGFβ) by growing cultures of osteoblast‐like cells

1993 • 124 citations

Latent Forms of Transforming Growth Factor-β (TGFβ) Derived from Bone Cultures: Identification of a Naturally Occurring 100-kDa Complex with Similarity to Recombinant Latent TGFβ

1991 • 119 citations

Expression of human bone-related proteins in the hematopoietic microenvironment.

1990 • 117 citations

Transcriptional Regulation of Osteocalcin Production by Transforming Growth Factor-β in Rat Osteoblast-Like Cells

1989 • 114 citations

The mechanism for the activation of latent TGF-beta during co-culture of endothelial cells and smooth muscle cells: cell-type specific targeting of latent TGF-beta to smooth muscle cells.

1993 • 114 citations

Effects of transforming growth factor β and epidermal growth factor on cell proliferation and the formation of bone nodules in isolated fetal rat calvaria cells

1989 • 107 citations

Experimental allergic encephalomyelitis: Neutralizing antibody to TGFβ1 enhances the clinical severity of the disease

1993 • 102 citations

Early strain-related changes in cultured embryonic chick tibiotarsi parallel those associated with adaptive modeling in vivo

1993 • 78 citations

Characterization of the 1,25-(OH)2D3-induced inhibition of bone nodule formation in long-term cultures of fetal rat calvaria cells.

1993 • 74 citations

γ‐Interferon‐Induced Activation of Latent Transforming Growth Factor‐β by Human Monocytes

1990 • 73 citations

Evolutionary Origins of the Transforming Growth Factor-β Gene Family

1992 • 71 citations

Transforming growth factor-beta 1 stimulates chondrogenesis and inhibits osteogenesis in high density culture of periosteum-derived cells

1993 • 60 citations

Constitutive transcription of the osteocalcin gene in osteosarcoma cells is reflected by altered protein-DNA interactions at promoter regulatory elements.

1993 • 52 citations

TGF‐β and Wound Healing

2007 • 50 citations

Differentiation of normal human bone cells by transforming growth factor-β and 1,25(OH)2 vitamin D3

1992 • 48 citations

Recombinant human bone morphogenetic protein‐2 enhances expression of interleukin‐6 and transforming growth factor‐β1 genes in normal human osteoblast‐like cells

1994 • 38 citations

Recombinant human transforming growth factor β1 modulates bone remodeling in a mineralizing bone organ culture

1993 • 34 citations

Characterization of the 1,25-(OH)2D3-induced inhibition of bone nodule formation in long-term cultures of fetal rat calvaria cells

1993 • 26 citations

Glucocorticoid regulation of transforming growth factor-beta activation in urogenital sinus mesenchymal cells.

1992 • 24 citations

Transforming growth factor β increases ecto-nucleoside triphosphate pyrophosphatase activity of human bone-derived cells

1994 • 22 citations

Glucocorticoid regulation of transforming growth factor-beta activation in urogenital sinus mesenchymal cells

1992 • 7 citations