Importance of specific purine amino and hydroxyl groups for efficient cleavage by a hammerhead ribozyme.

Simple RNA enzymes with new and highly specific endoribonuclease activities

1988 • 1,118 citations

A small catalytic oligoribonucleotide

1987 • 938 citations

Kinetic Characterization of Ribonuclease-Resistant 2′-Modified Hammerhead Ribozymes

1991 • 466 citations

Sequence requirements of the hammerhead RNA self-cleavage reaction

1990 • 466 citations

Self-cleavage of virusoid RNA is performed by the proposed 55-nucleotide active site

1987 • 323 citations

Chemical synthesis of biologically active oligoribonucleotides using β-cyanoethyl protected ribonucleoside phosphoramidites

1990 • 262 citations

Configurationally defined phosphorothioate-containing oligoribonucleotides in the study of the mechanism of cleavage of hammerhead ribozymes

1991 • 245 citations

Substrate sequence effects on "hammerhead" RNA catalytic efficiency.

1990 • 238 citations

Effects of phosphorothioate and 2-amino groups in hammerhead ribozymes on cleavage rates and magnesium binding

1991 • 182 citations

Self-cleavage of RNA in the replication of small pathogens of plants and animals

1989 • 177 citations

Two autolytic processing reactions of a satellite RNA proceed with inversion of configuration

1990 • 174 citations

Mixed deoxyribo- and ribo-oligonucleotides with catalytic activity

1990 • 167 citations

Thiophosphate interference experiments locate phosphates important for the hammerhead RNA self-cleavage reaction

1990 • 161 citations

Geometry of the First Step in the Action of Ribonuclease-A

1972 • 142 citations

Design of RNA enzymes distinguishing a single base mutation in RNA

1989 • 126 citations

Relationship between 2'-hydroxyls and magnesium binding in the hammerhead RNA domain: a model for ribozyme catalysis

1991 • 123 citations

Cleavage of specific sites of RNA by designed ribozymes

1988 • 113 citations

Study of a hammerhead ribozyme containing 2'-modified adenosine residues

1991 • 98 citations

Nuclear magnetic resonance studies of the hammerhead ribozyme domain

1991 • 96 citations

Function of specific 2'-hydroxyl groups of guanosines in a hammerhead ribozyme probed by 2' modifications.

1992 • 96 citations

A catalytic 13-mer ribozyme

1989 • 92 citations

Role of the tertiary nucleotides in the interaction of yeast phenylalanine tRNA with its cognate synthetase

1990 • 86 citations

Studies on the hammerhead RNA self-cleaving domain

1989 • 81 citations

Mixed DNA/RNA polymers are cleaved by the hammerhead ribozyme

1990 • 63 citations

A computational approach to the mechanism of self-cleavage of hammerhead RNA.

1989 • 38 citations

The role of a conserved guanosine residue in the hammerhead‐type RNA enzyme

1990 • 35 citations

Identification of a non-junction phosphodiester that influences an autolytic processing reaction of RNA

1990 • 33 citations