Importance of specific adenosine N7-nitrogens for efficient cleavage by a hammerhead ribozyme. A model for magnesium binding

Principles of Nucleic Acid Structure

2008 • 4,570 citations

Conformational analysis. 130. MM2. A hydrocarbon force field utilizing V1 and V2 torsional terms

1977 • 3,502 citations

Simple RNA enzymes with new and highly specific endoribonuclease activities

1988 • 1,118 citations

A small catalytic oligoribonucleotide

1987 • 938 citations

Synthesis of deoxyoligonucleotides on a polymer support

1981 • 870 citations

Self-cleavage of plus and minus RNAs of a virusoid and a structural model for the active sites

1987 • 660 citations

Kinetic Characterization of Ribonuclease-Resistant 2′-Modified Hammerhead Ribozymes

1991 • 466 citations

Sequence requirements of the hammerhead RNA self-cleavage reaction

1990 • 466 citations

Transient protection: efficient one-flask syntheses of protected deoxynucleosides

1982 • 385 citations

The automated chemical synthesis of long oligoribuncleotides using 2'-O-silylated ribonucleoside 3'-O-phosphoramidites on a controlled-pore glass support: synthesis of a 43-nucleotide sequence similar to the 3'-half molecule of an Escherichia coli formylmethionine tRNA

1987 • 367 citations

Role of divalent metal ions in the hammerhead RNA cleavage reaction

1991 • 365 citations

A crystallographic study of metal-binding to yeast phenylalanine transfer RNA

1977 • 322 citations

Crystal structure of an RNA double helix incorporating a track of non-Watson–Crick base pairs

1991 • 305 citations

Catalysis of RNA cleavage by the Tetrahymena thermophila ribozyme. 1. Kinetic description of the reaction of an RNA substrate complementary to the active site

1990 • 280 citations

Chemical synthesis of biologically active oligoribonucleotides using β-cyanoethyl protected ribonucleoside phosphoramidites

1990 • 262 citations

Configurationally defined phosphorothioate-containing oligoribonucleotides in the study of the mechanism of cleavage of hammerhead ribozymes

1991 • 245 citations

Substrate sequence effects on "hammerhead" RNA catalytic efficiency.

1990 • 238 citations

RNA - ligand interactions:(I) magnesium binding sites in yeast tRNA^Phe

1977 • 221 citations

Effects of phosphorothioate and 2-amino groups in hammerhead ribozymes on cleavage rates and magnesium binding

1991 • 182 citations

Self-cleavage of RNA in the replication of small pathogens of plants and animals

1989 • 177 citations

A magnetotelluric sounding across Vancouver Island detects the subducting Juan de Fuca plate

1986 • 175 citations

Two autolytic processing reactions of a satellite RNA proceed with inversion of configuration

1990 • 174 citations

Mixed deoxyribo- and ribo-oligonucleotides with catalytic activity

1990 • 167 citations

Ribozyme recognition of RNA by tertiary interactions with specific ribose 2′-OH groups

1991 • 165 citations

Thiophosphate interference experiments locate phosphates important for the hammerhead RNA self-cleavage reaction

1990 • 161 citations

Novel guanosine requirement for catalysis by the hairpin ribozyme

1991 • 142 citations

Structure of binary complexes of mono- and polynucleotides with metal ions of the first transition group

1980 • 131 citations

Design of RNA enzymes distinguishing a single base mutation in RNA

1989 • 126 citations

Relationship between 2'-hydroxyls and magnesium binding in the hammerhead RNA domain: a model for ribozyme catalysis

1991 • 123 citations

Minimum ribonucleotide requirement for catalysis by the RNA hammerhead domain

1992 • 114 citations

Cleavage of specific sites of RNA by designed ribozymes

1988 • 113 citations

Comparison of binding of mixed ribose-deoxyribose analogs of CUCU to a ribozyme and to GGAGAA by equilibrium dialysis: evidence for ribozyme specific interactions with 2'-hydroxy groups

1991 • 108 citations

Nuclear magnetic resonance studies of the hammerhead ribozyme domain

1991 • 96 citations

Function of specific 2'-hydroxyl groups of guanosines in a hammerhead ribozyme probed by 2' modifications.

1992 • 96 citations

A catalytic 13-mer ribozyme

1989 • 92 citations

Unpaired cytosine in the deoxyoligonucleotide duplex dCA3CA3G.cntdot.dCT6G is outside of the helix

1983 • 85 citations

Solid-phase synthesis and high-resolution NMR studies of two synthetic double-helical RNA dodecamers: r(CGCGAAUUCGCG) and r(CGCGUAUACGCG)

1989 • 85 citations

Studies on the hammerhead RNA self-cleaving domain

1989 • 81 citations

Importance of specific purine amino and hydroxyl groups for efficient cleavage by a hammerhead ribozyme.

1992 • 69 citations

Sequence-dependent structural variations of hammerhead RNA enzymes

1990 • 69 citations

Mixed DNA/RNA polymers are cleaved by the hammerhead ribozyme

1990 • 63 citations

Crystallographic studies of interactions between nucleotides and metal ions. II. The crystal and molecular structure of the 1:1 complex of cadmium(II) with guanosine 5'-phosphate

1976 • 61 citations

The chemical synthesis of oligoribonucleotides. IX. A comparison of protecting groups in the dichloridite procedure

1980 • 51 citations

Structural and Ionic Requirements for Self-cleavage of Virusoid RNAs and trans Self-cleavage of Viroid RNA

1987 • 50 citations

The role of the exocyclic amino groups of conserved purines in hammerhead ribozyme cleavage

1992 • 45 citations

Modified phosphotriester method for chemical synthesis of ribooligonucleotides. Part I. Synthesis of riboundecaadenylate and two fragments constituting the sequence of R-17 translation control signal

1982 • 42 citations

Dipeptide–metal–purine complexes as models for enzyme–metal–nucleic acid ternary species. Interligand hydrogen bonding and the conformational properties of (glycylglycinato)(aqua)(9-methyladenine)copper(II) tetrahydrate

1976 • 40 citations

A computational approach to the mechanism of self-cleavage of hammerhead RNA.

1989 • 38 citations

Interactions between the trp repressor and its operator sequence as studied by base analog substitution

1992 • 36 citations

Identification of a non-junction phosphodiester that influences an autolytic processing reaction of RNA

1990 • 33 citations

Preparation of Protected Ribonucleosides Suitable for Chemical Oligoribonucleotide Synthesis

1985 • 25 citations

Convenient procedure for the preparation of specific mixed DNA-RNA polymers

1989 • 15 citations