Promoter analysis meets pattern formation: transcriptional regulatory genes in sea urchin embryogenesis

Gene Activity in Early Development

1968 • 1,725 citations

Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis.

1992 • 536 citations

A single amino acid can determine the DNA binding specificity of homeodomain proteins

1989 • 531 citations

Experimental embryology of echinoderms

1973 • 465 citations

NRF-1, an activator involved in nuclear-mitochondrial interactions, utilizes a new DNA-binding domain conserved in a family of developmental regulators.

1993 • 343 citations

The orthodenticle gene encodes a novel homeo domain protein involved in the development of the Drosophila nervous system and ocellar visual structures.

1990 • 326 citations

EXPRESSION AND ORGANIZATION OF HISTONE GENES

1983 • 309 citations

Developmental Biology of the Sea Urchin Embryo

1973 • 285 citations

Mediation of Drosophila head development by gap-like segmentation genes

1990 • 271 citations

How embryos work: a comparative view of diverse modes of cell fate specification

1990 • 267 citations

A novel B-cell lineage-specific transcription factor present at early but not late stages of differentiation.

1990 • 244 citations

Gene Activity in Early Development

1988 • 237 citations

The ancestry of the vertebrates

1986 • 228 citations

Spatial mechanisms of gene regulation in metazoan embryos

1991 • 227 citations

A Genetic Model for Interaction of the Homeodomain Recognition Helix with DNA

1991 • 216 citations

A Complete Second Gut Induced by Transplanted Micromeres in the Sea Urchin Embryo

1993 • 183 citations

Position-dependent expression of two related homeobox genes in developing vertebrate limbs

1991 • 181 citations

The B cell-specific transcription factor BSAP regulates B cell proliferation.

1994 • 140 citations

Whole mount in situ hybridization shows Endo 16 to be a marker for the vegetal plate territory in sea urchin embryos

1993 • 131 citations

Cloning and evolutionary analysis of msh-like homeobox genes from mouse, zebrafish and ascidian

1991 • 122 citations

Gene regulatory factors of the sea urchin embryo: I. Purification by affinity chromatography and cloning of P3A2, a novel DNA-binding protein

1991 • 103 citations

Comparison of homeobox-containing genes of the honeybee and Drosophila.

1989 • 100 citations

Cell type specification during sea urchin development

1991 • 100 citations

Determination and morphogenesis in the sea urchin embryo

1987 • 99 citations

An erythrocyte-specific protein that binds to the poly(dG) region of the chicken beta-globin gene promoter.

1988 • 99 citations

Persistence and integration of cloned DNA in postembryonic sea urchins

1985 • 96 citations

The oral-aboral axis of a sea urchin embryo is specified by first cleavage

1989 • 94 citations

Cell type specification during sea urchin development

1991 • 91 citations

The Drosophila erect wing Gene, Which Is Important for both Neuronal and Muscle Development, Encodes a Protein Which Is similar to the Sea Urchin P3A2 DNA Binding Protein

1993 • 90 citations

Epithelio--mesenchymal interactions are critical for Quox 7 expression and membrane bone differentiation in the neural crest derived mandibular mesenchyme.

1991 • 86 citations

A Sea Urchin Gene Encodes a Polypeptide Homologous to Epidermal Growth Factor

1987 • 80 citations

Complexity and organization of DNA-protein interactions in the 5′-regulatory region of an endoderm-specific marker gene in the sea urchin embryo

1994 • 80 citations

Endo16, a lineage-specific protein of the sea urchin embryo, is first expressed just prior to gastrulation

1989 • 78 citations

Structure and expression pattern of the murine Hox-3.2 gene

1990 • 73 citations

A myogenic factor from sea urchin embryos capable of programming muscle differentiation in mammalian cells.

1991 • 70 citations

Progressively restricted expression of a homeo box gene within the aboral ectoderm of developing sea urchin embryos.

1989 • 65 citations

The transcription factor BSAP (NF-HB) is essential for immunoglobulin germ-line epsilon transcription.

1994 • 64 citations

The Drosophila erect wing gene, which is important for both neuronal and muscle development, encodes a protein which is similar to the sea urchin P3A2 DNA binding protein.

1993 • 63 citations

Multiple Otx Binding Sites Required for Expression of the Strongylocentrotus purpuratus Spec2a Gene

1994 • 63 citations

Negative spatial regulation of the lineage specific CyIIIa actin gene in the sea urchin embryo

1990 • 61 citations

Genomic Structure, Chromosomal Location, and Evolution of the Mouse Hox 8 Gene

1993 • 61 citations

Competitive titration in living sea urchin embryos of regulatory factors required for expression of the Cyllla actin gene

1990 • 54 citations

Phorbol esters alter cell fate during development of sea urchin embryos.

1992 • 51 citations

A regulatory domain that directs lineage-specific expression of a skeletal matrix protein gene in the sea urchin embryo.

1988 • 50 citations

SpCOUP-TF: a sea urchin member of the steroid/thyroid hormone receptor family.

1992 • 48 citations

Developmental and tissue-specific regulation of a novel transcription factor of the sea urchin.

1989 • 48 citations

Structure of an ectodermally expressed sea urchin metallothionein gene and characterization of its metal-responsive region.

1989 • 47 citations

Developmental control of promoter-specific factors responsible for the embryonic activation and inactivation of the sea urchin early histone H3 gene.

1989 • 44 citations

Gene regulatory factors of the sea urchin embryo: II. Two dissimilar proteins, P3A1 and P3A2, bind to the same target sites that are required for early territorial gene expression

1991 • 42 citations

Expression of two mRNAs encoding EGF-related proteins identifies subregions of sea urchin embryonic ectoderm

1991 • 39 citations

Stage- and tissue-specific expression of two homeo box genes in sea urchin embryos and adults

1988 • 38 citations

Characterization and expression of two sea urchin homeobox gene sequences

1990 • 36 citations

Expression of spatially regulated genes in the sea urchin embryo

1992 • 32 citations

Ligand-dependent stimulation of introduced mammalian brain receptors alters spicule symmetry and other morphogenetic events in sea urchin embryos

1994 • 27 citations

Developmental potential of muscle cell progenitors and the myogenic factor SUM-1 in the sea urchin embryo

1993 • 27 citations

SpOct, a Gene Encoding the Major Octamer-Binding Protein in Sea Urchin Embryos: Expression Profile, Evolutionary Relationships, and DNA Binding of Expressed Protein

1993 • 27 citations

A Positive cis-Regulatory Element with a bicoid Target Site Lies within the Sea Urchin Spec2a Enhancer

1993 • 27 citations

An octamer element is required for the expression of the alpha H2B histone gene during the early development of the sea urchin

1992 • 24 citations

Combinatorial Regulation by Promoter and Intron 1 Regions of the Metallothionein SpMTA Gene in the Sea Urchin Embryo

1993 • 24 citations

An embryonic enhancer determines the temporal activation of a sea urchin late H1 gene.

1989 • 23 citations

Positive and negative transcriptional regulatory elements in the early H4 histone gene of the sea urchin,Strongylocentrotus purpuratus

1990 • 22 citations

Rapid repetitive microinjection.

1986 • 20 citations

Posttranscriptional regulation of ectoderm-specific gene expression in early sea urchin embryos

1992 • 20 citations

Activation of the L1 late H2B histone gene in blastula-stage sea urchin embryos by an Antennapedia-class homeoprotein

1991 • 20 citations

Sea urchin early histone H2A modulator binding factor 1 is a positive transcription factor also for the early histone H3 gene.

1993 • 19 citations

Activation of a late H2B histone gene in blastula-stage sea urchin embryos by an unusual enhancer element located 3' of the gene.

1990 • 19 citations

Combinatorial regulation by promoter and intron 1 regions of the metallothionein SpMTA gene in the sea urchin embryo.

1993 • 19 citations

UHF-1, a Factor Required for Maximal Transcription of Early and Late Sea Urchin Histone H4 Genes: Analysis of Promoter-Binding Sites

1991 • 18 citations

Upstream Elements Involved in the Embryonic Regulation of the Sea Urchin CyIIIb Actin Gene: Temporal and Spatial Specific Interactions at a Single cis-Acting Element

1993 • 16 citations

Purification of an Oligo(dG). Oligo(dC)-Binding Sea Urchin Nuclear Protein, suGF1: a Family of G-string Factors Involved in Gene Regulation During Development

1994 • 16 citations

Temporal Embryonic Expression of the Sea Urchin Early H1 Gene Is Controlled by Sequences Immediately Upstream and Downstream of the TATA Element

1993 • 15 citations

Purification and characterization of the stage-specific embryonic enhancer-binding protein SSAP-1.

1993 • 15 citations

Chapter 22 Rapid Repetitive Microinjection

1986 • 14 citations

Territorial expression of three different trans-genes in early sea urchin embryos detected by a whole-mount fluorescence procedure

1992 • 14 citations

UHF-1, a factor required for maximal transcription of early and late sea urchin histone H4 genes: analysis of promoter-binding sites.

1991 • 13 citations

Purification of an oligo(dG).oligo(dC)-binding sea urchin nuclear protein, suGF1: a family of G-string factors involved in gene regulation during development.

1994 • 13 citations

A POU gene required for early cleavage and protein accumulation in the sea urchin embryo

1994 • 12 citations

suGF1 binds in the major groove of its oligo(dG).oligo(dC) recognition sequence and is excluded by a positioned nucleosome core.

1994 • 11 citations