Expression of spatially regulated genes in the sea urchin embryo

Gene Activity in Early Development

1968 • 1,725 citations

In situ detection of sequence-specific DNA binding activity specified by a recombinant bacteriophage.

1988 • 535 citations

How embryos work: a comparative view of diverse modes of cell fate specification

1990 • 267 citations

Lineage-specific gene expression and the regulative capacities of the sea urchin embryo: a proposed mechanism

1989 • 249 citations

Gene Activity in Early Development

1970 • 236 citations

Spatial mechanisms of gene regulation in metazoan embryos

1991 • 227 citations

Lineage and fate of each blastomere of the eight-cell sea urchin embryo.

1987 • 204 citations

Cell lineage-specific programs of expression of multiple actin genes during sea urchin embryogenesis

1986 • 178 citations

Early expression of a collagenase-like hatching enzyme gene in the sea urchin embryo.

1990 • 158 citations

A lineage-specific gene encoding a major matrix protein of the sea urchin embryo spicule

1987 • 154 citations

Sequential expression of germ-layer specific molecules in the sea urchin embryo

1985 • 144 citations

Early mRNAs, spatially restricted along the animal-vegetal axis of sea urchin embryos, include one encoding a protein related to tolloid and BMP-1

1992 • 128 citations

The organic matrix of the skeletal spicule of sea urchin embryos.

1986 • 122 citations

Developmental appearance of factors that bind specifically to cis-regulatory sequences of a gene expressed in the sea urchin embryo.

1988 • 119 citations

A lineage-specific gene encoding a major matrix protein of the sea urchin embryo spicule

1987 • 115 citations

Localization of a family of MRNAS in a single cell type and its precursors in sea urchin embryos.

1983 • 114 citations

Gene regulatory factors of the sea urchin embryo: I. Purification by affinity chromatography and cloning of P3A2, a novel DNA-binding protein

1991 • 103 citations

Cell type specification during sea urchin development

1991 • 100 citations

Cell type specification during sea urchin development

1991 • 91 citations

Characterization and expression of a gene encoding a 30.6-kDa Strongylocentrotus purpuratus spicule matrix protein

1991 • 89 citations

Endo16, a lineage-specific protein of the sea urchin embryo, is first expressed just prior to gastrulation

1989 • 78 citations

The corrected structure of the SM50 spicule matrix protein of Strongylocentrotus purpuratus

1991 • 72 citations

Spec2 genes of Strongylocentrotus purpuratus

1988 • 71 citations

A myogenic factor from sea urchin embryos capable of programming muscle differentiation in mammalian cells.

1991 • 70 citations

Structure and tissue-specific developmental expression of a sea urchin arylsulfatase gene

1989 • 65 citations

Progressively restricted expression of a homeo box gene within the aboral ectoderm of developing sea urchin embryos.

1989 • 65 citations

Negative spatial regulation of the lineage specific CyIIIa actin gene in the sea urchin embryo

1990 • 61 citations

Regulatory elements from the related spec genes of Strongylocentrotus purpuratus yield different spatial patterns with a lacZ reporter gene

1990 • 61 citations

Structure and developmental expression of a sea urchin fibrillar collagen gene.

1989 • 61 citations

Metallothionein Genes MTa and MTb Expressed under Distinct Quantitative and Tissue-Specific Regulation in Sea Urchin Embryos

1987 • 60 citations

Cloning of a fibrillar collagen gene expressed in the mesenchymal cells of the developing sea urchin embryo.

1990 • 56 citations

Competitive titration in living sea urchin embryos of regulatory factors required for expression of the Cyllla actin gene

1990 • 54 citations

Fibropellins, products of an EGF repeat-containing gene, form a unique extracellular matrix structure that surrounds the sea urchin embryo

1991 • 53 citations

Structure, spatial, and temporal expression of two sea urchin metallothionein genes, SpMTB1 and SpMTA.

1991 • 52 citations

Sequences of the CyIIIa actin gene regulatory domain bound specifically by sea urchin embryo nuclear proteins

1990 • 50 citations

A regulatory domain that directs lineage-specific expression of a skeletal matrix protein gene in the sea urchin embryo.

1988 • 50 citations

Repetitive DNA sequences linked to the sea urchin spec genes contain transcriptional enhancer-like elements

1990 • 48 citations

Structure of an ectodermally expressed sea urchin metallothionein gene and characterization of its metal-responsive region.

1989 • 47 citations

Transcription of the Spec 1-like gene of Lytechinus is selectively inhibited in response to disruption of the extracellular matrix

1989 • 45 citations

Expression of a collagen gene in mesenchyme lineages of the Strongylocentrotus purpuratus embryo.

1988 • 45 citations

Unusual Pattern of Accumulation of mRNA Encoding EGF-Related Protein in Sea Urchin Embryos

1989 • 43 citations

Metallothionein genes MTa and MTb expressed under distinct quantitative and tissue-specific regulation in sea urchin embryos.

1987 • 43 citations

Gene regulatory factors of the sea urchin embryo: II. Two dissimilar proteins, P3A1 and P3A2, bind to the same target sites that are required for early territorial gene expression

1991 • 42 citations

Myosin heavy chain accumulates in dissimilar cell types of the macromere lineage in the sea urchin embryo

1990 • 42 citations

Temporal and spatial transcriptional regulation of the aboral ectoderm‐specific spec genes during sea urchin embryogenesis

1990 • 41 citations

Expression of two mRNAs encoding EGF-related proteins identifies subregions of sea urchin embryonic ectoderm

1991 • 39 citations

Promoter structure and protein sequence of msp130, a lipid-anchored sea urchin glycoprotein.

1990 • 38 citations

Spatial Patterns of Arylsulfatase mRNA Expression in Sea Urchin Embryo

1990 • 38 citations

Gastrulation in the sea urchin is accompanied by the accumulation of an endoderm-specific mRNA

1989 • 35 citations

The accumulation and translation of a spicule matrix protein mRNA during sea urchin embryo development

1989 • 35 citations

Sea urchin USF: A helix-loop-helix protein active in embryonic ectoderm cells

1991 • 34 citations

Ectoderm nuclei from sea urchin embryos contain a Spec–DNA binding protein similar to the vertebrate transcription factor USF

1990 • 33 citations

Tandem duplication and divergence of a sea urchin protein belonging to the troponin C superfamily.

1988 • 32 citations

Spec3: embryonic expression of a sea urchin gene whose product is involved in ectodermal ciliogenesis.

1987 • 32 citations

Coordinate accumulation of five transcripts in the primary mesenchyme during skeletogenesis in the sea urchin embryo

1988 • 32 citations

Intersecting batteries of differentially expressed genes in the early sea urchin embryo.

1990 • 31 citations

Transcription of three actin genes and a repeated sequence in isolated nuclei of sea urchin embryos

1987 • 29 citations

Structure and promoter activity of the LpS1 genes of Lytechinus pictus. Duplicated exons account for LpS1 proteins with eight calcium binding domains

1991 • 29 citations

A G-string positive cis-regulatory element in the LpS1 promoter binds two distinct nuclear factors distributed non-uniformly in Lytechinus pictus embryos

1991 • 28 citations

An embryonic enhancer determines the temporal activation of a sea urchin late H1 gene.

1989 • 23 citations

Rare maternal mRNAs code for regulatory proteins that control lineage-specific gene expression in the sea urchin embryo.

1990 • 21 citations

Tissue-restricted accumulation of a ribosomal protein mRNA is not coordinated with rRNA transcription and precedes growth of the sea urchin pluteus larva

1992 • 20 citations

Activation of the L1 late H2B histone gene in blastula-stage sea urchin embryos by an Antennapedia-class homeoprotein

1991 • 20 citations

Automated sequential affinity chromatography of sea urchin embryo DNA binding proteins.

1992 • 18 citations

Territorial expression of three different trans-genes in early sea urchin embryos detected by a whole-mount fluorescence procedure

1992 • 14 citations

Expression of myosin heavy chain gene in the sea urchin: Coregulation with muscle actin transcription in early development

1987 • 10 citations