Functional and Anatomical Aspects of Prefrontal Pathology in Schizophrenia

Studies of interference in serial verbal reactions.

1935 • 17,279 citations

The Brief Psychiatric Rating Scale

1962 • 10,683 citations

Handbook of Physiology.

1960 • 10,428 citations

Human Problem Solving.

1973 • 7,028 citations

Human Memory: A Proposed System and its Control Processes

1968 • 6,466 citations

The Psychology of Learning and Motivation: Advances in Research and Theory

2010 • 6,012 citations

Human Problem Solving

1972 • 5,155 citations

Specific impairments of planning

1982 • 3,603 citations

Wisconsin Card Sorting Test Manual – Revised and Expanded

1981 • 2,973 citations

Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex

1989 • 2,677 citations

Synaptic density in human frontal cortex — Developmental changes and effects of aging

1979 • 2,587 citations

The neural correlates of the verbal component of working memory

1993 • 2,236 citations

A continuous performance test of brain damage.

1956 • 2,206 citations

Neuron Activity Related to Short-Term Memory

1971 • 2,071 citations

Physiologic Dysfunction of Dorsolateral Prefrontal Cortex in Schizophrenia

1986 • 2,026 citations

Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: A hypothesis for the etiology of schizophrenia

1991 • 1,819 citations

Glutamate Receptor Dysfunction and Schizophrenia

1995 • 1,682 citations

Topography of Cognition: Parallel Distributed Networks in Primate Association Cortex

1988 • 1,649 citations

Modulation of memory fields by dopamine Dl receptors in prefrontal cortex

1995 • 1,600 citations

Practice-related Changes in Human Brain Functional Anatomy during Nonmotor Learning

1994 • 1,559 citations

Cognitive Deficit Caused by Regional Depletion of Dopamine in Prefrontal Cortex of Rhesus Monkey

1979 • 1,496 citations

Wisconsin Card Sorting Test manual

1993 • 1,489 citations

Society for Neuroscience Abstracts

1997 • 1,445 citations

Dissociation of Object and Spatial Processing Domains in Primate Prefrontal Cortex

1993 • 1,420 citations

Schizophrenia: Caused by a fault in programmed synaptic elimination during adolescence?

1982 • 1,352 citations

Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 pKi values.

1989 • 1,313 citations

Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects.

1996 • 1,275 citations

Abnormalities of the Left Temporal Lobe and Thought Disorder in Schizophrenia

1992 • 1,173 citations

Posterior parietal cortex in rhesus monkey: II. Evidence for segregated corticocortical networks linking sensory and limbic areas with the frontal lobe

1989 • 1,146 citations

Concurrent Overproduction of Synapses in Diverse Regions of the Primate Cerebral Cortex

1986 • 1,126 citations

THE BRIEF PSYCHIATRIC RATING SCALE

1962 • 1,091 citations

The left frontal lobe of man and the suppression of habitual responses in verbal categorical behaviour☆

1974 • 1,015 citations

Frontal lobe lesions in man cause difficulties in suppressing reflexive glances and in generating goal-directed saccades

1985 • 1,014 citations

Dissociating Verbal and Spatial Working Memory Using PET

1996 • 961 citations

Schizophrenics Show Spatial Working Memory Deficits

1992 • 953 citations

Semantic encoding and retrieval in the left inferior prefrontal cortex: a functional MRI study of task difficulty and process specificity

1995 • 920 citations

Object and Spatial Visual Working Memory Activate Separate Neural Systems in Human Cortex

1996 • 907 citations

Common cortical and subcortical targets of the dorsolateral prefrontal and posterior parietal cortices in the rhesus monkey: evidence for a distributed neural network subserving spatially guided behavior

1988 • 906 citations

Patterns of Cerebral Blood Flow in Schizophrenia

1992 • 905 citations

Deficits in Small Interneurons in Prefrontal and Cingulate Cortices of Schizophrenic and Schizoaffective Patients

1991 • 889 citations

Hypofrontality in Neuroleptic-Naive Patients and in Patients With Chronic Schizophrenia

1992 • 882 citations

Prenatal developmental disturbances in the limbic allocortex in schizophrenics

1986 • 879 citations

Abnormally High Neuronal Density in the Schizophrenic Cortex

1995 • 866 citations

Some effects of frontal lobectomy in man

1964 • 852 citations

THE FRONTAL GRANULAR CORTEX AND BEHAVIOR

1964 • 836 citations

Posterior parietal cortex in rhesus monkey: I. Parcellation of areas based on distinctive limbic and sensory corticocortical connections

1989 • 802 citations

Dual pathways connecting the dorsolateral prefrontal cortex with the hippocampal formation and parahippocampal cortex in the rhesus monkey

1984 • 778 citations

Evidence for a Two-Stage Model of Spatial Working Memory Processing within the Lateral Frontal Cortex: A Positron Emission Tomography Study

1996 • 760 citations

Prefrontal cortical unit activity and delayed alternation performance in monkeys.

1971 • 703 citations

Thalamic Abnormalities in Schizophrenia Visualized Through Magnetic Resonance Image Averaging

1994 • 699 citations

Postmortem Evidence of Structural Brain Changes in Schizophrenia

1986 • 684 citations

Typical and atypical neuroleptics: differential effects of chronic administration on the activity of A9 and A10 midbrain dopaminergic neurons

1983 • 680 citations

Synaptogenesis in the Prefrontal Cortex of Rhesus Monkeys

1994 • 669 citations

Evidence of dysfunction of a prefrontal-limbic network in schizophrenia: a magnetic resonance imaging and regional cerebral blood flow study of discordant monozygotic twins

1992 • 665 citations

The primate mediodorsal (MD) nucleus and its projection to the frontal lobe

1985 • 652 citations

Differential Performance of Acute and Chronic Schizophrenics in a Latent Inhibition Task

1988 • 613 citations

Increased dopamine turnover in the prefrontal cortex impairs spatial working memory performance in rats and monkeys.

1996 • 599 citations

Towards a Neuropsychology of Schizophrenia

1988 • 588 citations

Positron emission tomography study of voluntary saccadic eye movements and spatial working memory

1996 • 583 citations

Activation of the prefrontal cortex in a nonspatial working memory task with functional MRI

1994 • 581 citations

Demonstrating the Implicit Processing of Visually Presented Words and Pseudowords

1996 • 550 citations

Neurobiology of Neocortex

1989 • 540 citations

The development of synapses in striate cortex of man.

1987 • 523 citations

Some Cytoarchitectural Abnormalities of the Entorhinal Cortex in Schizophrenia

1991 • 517 citations

Mediodorsal nucleus: Areal, laminar, and tangential distribution of afferents and efferents in the frontal lobe of rhesus monkeys

1988 • 516 citations

Brain Morphology and Schizophrenia

1992 • 508 citations

Schizophrenic Syndromes and Frontal Lobe Performance

1991 • 508 citations

Localization of dopamine D4 receptors in GABAergic neurons of the primate brain

1996 • 494 citations

Regional, cellular, and subcellular variations in the distribution of D1 and D5 dopamine receptors in primate brain

1995 • 486 citations

A positron emission tomography study of the short-term maintenance of verbal information

1996 • 481 citations

Alterations in Brain High-Energy Phosphate and Membrane Phospholipid Metabolism in First-Episode, Drug-Naive Schizophrenics

1991 • 481 citations

Performance of Schizophrenic Patients on Tests Sensitive To Left or Right Frontal, Temporal, or Parietal Function in Neurological Patients

1983 • 467 citations

Functional magnetic resonance imaging of human prefrontal cortex activation during a spatial working memory task.

1994 • 454 citations

NMDA receptor antagonists impair prefrontal cortex function as assessed via spatial delayed alternation performance in rats: modulation by dopamine

1996 • 450 citations

Magnetic Resonance Imaging of the Brain in Schizophrenia

1990 • 440 citations

Three‐dimensional counting: An accurate and direct method to estimate numbers of cells in sectioned material

1988 • 437 citations

Dopamine synaptic complex with pyramidal neurons in primate cerebral cortex.

1989 • 435 citations

Widespread Cerebral Gray Matter Volume Deficits in Schizophrenia

1992 • 421 citations

Distribution of dopaminergic receptors in the primate cerebral cortex: Quantitative autoradiographic analysis using [3H]raclopride, [3H]spiperone and [3H]SCH23390

1991 • 396 citations

Activation of Human Prefrontal Cortex during Spatial and Nonspatial Working Memory Tasks Measured by Functional MRI

1996 • 396 citations

Anteroposterior Gradients in Cerebral Glucose Use in Schizophrenia and Affective Disorders

1984 • 376 citations

Dopamine D1 receptor actions in layers V-VI rat prefrontal cortex neurons in vitro: modulation of dendritic-somatic signal integration

1996 • 371 citations

Associative semantic network dysfunction in thought-disordered schizophrenic patients: Direct evidence from indirect semantic priming

1993 • 350 citations

Schizophrenia: A Subcortical Neurotransmitter Imbalance Syndrome?

1990 • 335 citations

Regional distribution of monoamines in the cerebral cortex and subcortical structures of the rhesus monkey: concentrations and in vivo synthesis rates

1979 • 330 citations

Psychopathology and the Brain

1992 • 325 citations

Glucose Metabolic Rate in Normals and Schizophrenics During the Continuous Performance Test Assessed by Positron Emission Tomography

1990 • 321 citations

Smooth-Pursuit Eye Movement Representation in the Primate Frontal Eye Field

1991 • 314 citations

Overlap of dopaminergic, adrenergic, and serotoninergic receptors and complementarity of their subtypes in primate prefrontal cortex

1990 • 314 citations

Coactivation of prefrontal cortex and inferior parietal cortex in working memory tasks revealed by 2DG functional mapping in the rhesus monkey

1994 • 313 citations

Recent Advances in the Neuropathology of Schizophrenia

1993 • 285 citations

Characterization of the Dopaminergic Innervation of the Primate Frontal Cortex Using a Dopamine-specific Antibody

1993 • 283 citations

The comparative efficacy and long-term effect of clozapine treatment on neuropsychological test performance

1994 • 283 citations

Psychopathology and the Brain

1991 • 279 citations

Immunocytochemical localization of dopamine in the prefrontal cortex of the rat at the light and electron microscopical level

1987 • 276 citations

Disturbances of voluntary control of saccadic eye movements in schizophrenic patients

1988 • 267 citations

Complex Information Processing

2013 • 265 citations

Cortical Pruning and the Development of Schizophrenia: A Computer Model

1989 • 259 citations

Structural Abnormalities in the Cerebral Cortex of Chronic Schizophrenic Patients

1979 • 257 citations

Dopamine and norepinephrine innervated cells in the rat prefrontal cortex: Pharmacological differentiation using microiontophoretic techniques

1976 • 251 citations

Brain Electrical Activity Mapping (BEAM) in Schizophrenic Patients

1983 • 244 citations

Bilateral frontal lobe disease and selective delayed response deficits in humans.

1986 • 241 citations

Inhibitory effects of ventral tegmental area stimulation on the activity of prefrontal cortical neurons: Evidence for the involvement of both dopaminergic and GABAergic components

1992 • 240 citations

Regional Brain Glucose Metabolism in Chronic Schizophrenia

1984 • 237 citations

Chronic exposure to low doses of MPTP. I. Cognitive deficits in motor asymptomatic monkeys

1990 • 236 citations

Impairment of early cortical processing in schizophrenia: An event-related potential confirmation study

1993 • 233 citations

Axon terminals immunolabeled for dopamine or tyrosine hydroxylase synapse on GABA‐immunoreactive dendrites in rat and monkey cortex

1995 • 230 citations

Inhibitory influence of the mesocortical dopaminergic system on spontaneous activity or excitatory response induced from the thalamic mediodorsal nucleus in the rat medial prefrontal cortex

1984 • 228 citations

Immunocytochemical localization and description of neurons expressing serotonin2 receptors in the rat brain

1993 • 228 citations

Phenomenological correlates of metabolic activity in 18 patients with chronic schizophrenia

1987 • 216 citations

Altered synaptophysin expression as a marker of synaptic pathology in schizophrenia

1995 • 216 citations

Activation of the hippocampus and dentate gyrus by working-memory: a 2- deoxyglucose study of behaving rhesus monkeys

1988 • 213 citations

Learning and memory in monozygotic twins discordant for schizophrenia

1993 • 212 citations

Spatial memory impairments following damage to the mediodorsal nucleus of the thalamus in rhesus monkeys

1982 • 212 citations

Heterogeneous Targets of Dopamine Synapses in Monkey Prefrontal Cortex Demonstrated by Serial Section Electron Microscopy: A Laminar Analysis Using the Silver-enhanced Diaminobenzidine Sulfide (SEDS) Immunolabeling Technique

1993 • 209 citations

Total nerve cell number in neocortex in chronic schizophrenics and controls estimated using optical disectors

1993 • 208 citations

Dopamine D2 receptors in the cerebral cortex: distribution and pharmacological characterization with [3H]raclopride.

1989 • 208 citations

Effects of clozapine on cognitive function in schizophrenia.

1994 • 200 citations

Frontal lobe dysfunctions in schizophrenia—II. impairments of psychological and brain functions

1984 • 197 citations

Network of GABAergic large basket cells in cat visual cortex (area 18): Implication for lateral disinhibition

1993 • 194 citations

Dopamine modulation of synaptic transmission in rat prefrontal cortex: an in vitro electrophysiological study

1994 • 187 citations

Local circuit neurons of the prefrontal cortex in schizophrenia: selective increase in the density of calbindin-immunoreactive neurons

1995 • 186 citations

Anterior hippocampal volume reductions predict frontal lobe dysfunction in first episode schizophrenia

1995 • 183 citations

A common action of clozapine, haloperidol, and remoxipride on D1- and D2-dopaminergic receptors in the primate cerebral cortex.

1994 • 175 citations

Differential modulation by dopamine of responses evoked by excitatory amino acids in human cortex

1992 • 172 citations

Regulation of cortical and subcortical glutamate receptor subunit expression by antipsychotic drugs

1995 • 171 citations

Brain mechanisms of perception and memory : from neuron to behavior

1993 • 171 citations

Active Representation of Shape and Spatial Location in Man

1996 • 168 citations

Serotonin (5-HT) induces IPSPs in pyramidal layer cells of rat piriform cortex: evidence for the involvement of a 5-HT2 -activated interneuron

1990 • 167 citations

Ventricular Enlargement in Schizophrenia Evaluated With Computed Tomographic Scanning

1990 • 167 citations

Serotonergic axons in monkey prefrontal cerebral cortex synapse predominantly on interneurons as demonstrated by serial section electron microscopy

1996 • 164 citations

Hypofrontality and cognitive impairment in schizophrenia: Dynamic single-photon tomography and neuropsychological assessment of schizophrenic brain function

1990 • 159 citations

Pyramidal cells in piriform cortex receive a convergence of inputs from monoamine activated GABAergic interneurons

1993 • 158 citations

The Role of Working Memory in Language Comprehension

1988 • 150 citations

Brain morphology in first-episode schizophrenia

1995 • 147 citations

Association of working memory deficit and eye tracking dysfunction in schizophrenia

1993 • 143 citations

Ultrastructural relationships of serotonin axon terminals in the cerebral cortex of the adult rat

1989 • 142 citations

The immediacy hypothesis and response-produced stimuli in schizophrenic speech.

1970 • 137 citations

The Effects of Clozapine on Symptom Reduction, Neurocognitive Function, and Clinical Management in Treatment-Refractory State Hospital Schizophrenic Inpatients

1996 • 135 citations

Regional Cerebral Blood Flow in Schizophrenics

1983 • 135 citations

Wisconsin Card Sorting Test: an indicator of vulnerability to schizophrenia?

1992 • 127 citations

Quantitative magnetic resonance imaging of the brain in late-life schizophrenia

1995 • 123 citations

Neuropsychological probes of fronto-limbic system dysfunction in schizophrenia

1991 • 119 citations

Regional neuropathology in schizophrenia: Where are we? Where are we going?

1993 • 119 citations

Regional Cerebral Blood Flow in Schizophrenia

1982 • 117 citations

Schizophrenia as a brain disease

1982 • 117 citations

Auditory sensory ("echoic") memory dysfunction in schizophrenia

1995 • 116 citations

Absence of activation in frontal structures during psychological testing of chronic schizophrenics.

1975 • 116 citations

Neurological signs and the positive-negative dimension in schizophrenia

1990 • 115 citations

31P Nuclear Magnetic Resonance Spectroscopy: Neurodevelopment and Schizophrenia

1993 • 114 citations

Delayed response tasks and prefrontal lesions in man—Evidence for self generated patterns of behaviour with poor environmental modulation

1993 • 109 citations

Temporal lobe morphology in childhood-onset schizophrenia [published erratum appears in Am J Psychiatry 1996 Jun;153(6):851]

1996 • 108 citations

Study of chronic schizophrenics using ³¹P magnetic resonance chemical shift imaging

1992 • 107 citations

An evaluation of structural and functional prefrontal deficits in schizophrenia: MRI and neuropsychological measures

1992 • 105 citations

Opposing effects of dopamine D2 receptor stimulation on the spontaneous and the electrically evoked release of [3H]gaba on rat prefrontal cortex slices

1991 • 103 citations

Prefrontal sulcal prominence is inversely related to response to clozapine in schizophrenia

1991 • 100 citations

Role of the different frontal lobe areas in the control of the horizontal component of memory-guided saccades in man

1993 • 91 citations

The Effects of Haloperidol and Clozapine on Extracellular GABA Levels in the Prefrontal Cortex of the Rat: An in vivo Microdialysis Study

1994 • 82 citations

Abnormal Resting Regional Cerebral Blood Flow Patterns and Their Correlates in Schizophrenia

1988 • 82 citations

“Reverse” Stroop Effect in the Performance of Schizophrenics

1983 • 82 citations

Progress in experimental personality & psychopathology research

1992 • 79 citations

Serotonin2 receptor-mediated excitation of interneurons in piriform cortex: Antagonism by atypical antipsychotic drugs

1994 • 79 citations

Low frontal glucose utilization in chronic schizophrenia: a replication study

1988 • 77 citations

Topography Of Cognition: Parallel Distributed Networks In Primate Association Cortex

1988 • 77 citations

The Selective Attention Deficit in Schizophrenia

1989 • 72 citations

Converging models of cognitive deficit in schizophrenia.

1984 • 70 citations

Gray matter deficits in young onset schizophrenia are independent of age of onset

1996 • 70 citations

Patterns of regional cortical dysmorphology distinguishing schizophrenia and chronic alcoholism

1998 • 66 citations

A time course analysis of Stroop interference and facilitation: Comparing normal individuals and individuals with schizophrenia.

1997 • 66 citations

Regional Cerebral Blood Flow in Schizophrenic Disorders

1985 • 65 citations

Isolating the Mnemonic Component in Spatial Delayed Response: A Controlled PET15O-Labeled Water Regional Cerebral Blood Flow Study in Normal Humans

1996 • 63 citations

The effects of chronic haloperidol administration on GABA‐immunoreactive. Axon terminals in rat medial prefrontal cortex

1994 • 61 citations

Frontal brain volume and context effects in short-term recall in schizophrenia

1995 • 60 citations

Is There a Neuroanatomic Basis for Schizophrenia? An Old Question Revisited

1995 • 58 citations

Maladaptive anticipatory saccades in schizophrenia

1991 • 58 citations

Pathological cerebral blood flow during motor function in schizophrenic and endogenous depressed patients

1986 • 57 citations

Psychological, topographic EEG, and CT scan correlates of frontal lobe function in schizophrenia

1989 • 55 citations

Biology of schizophrenia and affective disease

1996 • 53 citations

Schizophrenia, an integrated view

1995 • 52 citations

Psychopathology: the evolving science of mental disorder

1997 • 51 citations

Distribution and neurochemical character of substance P receptor (SPR)-immunoreactive striatal neurons of the macaque monkey: Accumulation of SP fibers and SPR neurons and dendrites in ?striocapsules? encircling striosomes

1996 • 50 citations

Presynaptic and postsynaptic subcellular localization of substance P receptor immunoreactivity in the neostriatum of the rat and rhesus monkey (Macaca mulatta)

1996 • 49 citations

Preferential activation of dopamine overflow in prefrontal cortex produced by chronic clozapine treatment

1994 • 49 citations

REGIONAL CEREBRAL BLOOD FLOW IN SCHIZOPHRENICS

1984 • 49 citations

Correlation of regional cerebral blood flow with performance on neuropsychological tests in schizophrenic patients

1990 • 45 citations

Correlation of Negative Symptoms in Schizophrenia with Frontal Lobe Parameters on Magnetic Resonance Imaging

1991 • 42 citations

Clozapine and seizures

1995 • 41 citations

A time course analysis of Stroop interference and facilitation: Comparing normal individuals and individuals with schizophrenia.

1997 • 39 citations

Potency mismatch for behavioral and biochemical effects by dopamine receptor antagonists: implications for the mechanism of action of clozapine

1993 • 31 citations

Selective impairment of express saccade generation in patients with schizophrenia

1993 • 29 citations

The Role of Working Memory in Language Comprehension

1988 • 23 citations

Bilateral frontal lobe disease and selective delayed response deficits in humans.

1986 • 19 citations

Reduction in neuronal sizes in prefrontal cortex of schizophrenics and huntington patients

1995 • 16 citations

Abnormal frontotemporal interactions in patients with schizophrenia

1995 • 8 citations

The functional parcellation of dorsolateral prefrontal cortex and the heterogeneous facets of schizophrenia

1996 • 6 citations

Distribution and neurochemical character of substance P receptor (SPR)‐immunoreactive striatal neurons of the macaque monkey: Accumulation of SP fibers and SPR neurons and dendrites in “striocapsules” encircling striosomes

1996 • 6 citations

Enlargement of the Anterior Horn of the Lateral Ventricle in Schizophrenic Patients: Chronological and Morphometrical Studies

1990 • 4 citations

Functional magnetic resonance imaging of frontal cortex during performance of non-spatial associative memory tasks

1996 • 3 citations