Application of fluorescence in situ hybridization techniques in clinical genetics: use of two alphoid repeat probes detecting the centromeres of chromosomes 13 and 21 or chromosomes 14 and 22, respectively

Chromosome preparations of leukocytes cultured from human peripheral blood

1960 • 4,290 citations

Fluorescence in situ hybridization with human chromosome-specific libraries: detection of trisomy 21 and translocations of chromosome 4.

1988 • 1,334 citations

Delineation of individual human chromosomes in metaphase and interphase cells by in situ suppression hybridization using recombinant DNA libraries

1988 • 1,171 citations

Identification of human chromosomes by DNA-binding fluorescent agents

1970 • 989 citations

Localization of single copy DNA sequences on G-banded human chromosomes by in situ hybridization

1981 • 836 citations

High Resolution of Human Chromosomes

1976 • 786 citations

Hierarchical order in chromosome-specific human alpha satellite DNA

1987 • 510 citations

Detection of chromosome aberrations in the human interphase nucleus by visualization of specific target DNAs with radioactive and non-radioactive in situ hybridization techniques: diagnosis of trisomy 18 with probe L1.84

1986 • 380 citations

Oligonucleotide-priming methods for the chromosome-specific labelling of alpha satellite DNA in situ

1989 • 294 citations

Reproducible compartmentalization of individual chromosome domains in human CNS cells revealed by in situ hybridization and three-dimensional reconstruction

1988 • 279 citations

Rapid detection of human chromosome 21 aberrations by in situ hybridization.

1988 • 251 citations

Potential genetic functions of tandem repeated DNA sequence blocks in the human genome are based on a highly conserved ?chromatin folding code?

1990 • 207 citations

Characterization of the Supernumerary Chromosome in Cat Eye Syndrome

1986 • 159 citations

Two subsets of human alphoid repetitive DNA show distinct preferential localization in the pericentric regions of chromosomes 13, 18, and 21

1986 • 156 citations

Direct visualization of single copy genes on banded metaphase chromosomes by nonisotopicin situhybridization

1988 • 110 citations

Homologous subfamilies of human alphoid repetitive DNA on different nucleolus organizing chromosomes.

1987 • 105 citations

Homologous alpha satellite sequences on human acrocentric chromosomes with selectivity for chromosomes 13, 14 and 21: implications for recombination between nonhomologues and Robertsonian translocations

1988 • 89 citations

Sequence heterogeneity within the human alphoid repetitive DNA family

1986 • 80 citations

A subfamily of alphoid repetitive DNA shared by the nor-bearing human chromosomes 14 and 22

1988 • 68 citations

Isolation and characterization of an ?-satellite repeated sequence from human chromosome 22

1986 • 64 citations

Application of cloned satellite DNA sequences to molecular-cytogenetic analysis of constitutive heterochromatin heteromorphisms in man

1987 • 44 citations

An improved method for labelling of DNA probes by nicktranslation

1986 • 44 citations

An efficient method for selecting unique-sequence clones from DNA libraries and its application to fluorescent staining of human chromosome 21 using in situ hybridization

1989 • 41 citations

Organization and genomic distribution of ?82H? alpha satellite DNA

1988 • 34 citations

Parental origin of the extra chromosome in the cat eye syndrome: Evidence from heteromorphism and in situ hybridization analysis

1988 • 30 citations

Simultaneous identification and banding of human chromosome material in somatic cell hybrids

1988 • 29 citations

Improved methods for the detection of unique sequences in Southern blots of mammalian DNA by non-radioactive biotinylated DNA hybridization probes

1987 • 26 citations

Human chromosome-specific repetitive DNA probes: Targeting in situ hybridization to chromosome 17 with a 42-base-pair alphoid DNA oligomer

1989 • 11 citations

In situ hybridization analysis of isodicentric X‐chromosomes with short arm fusion

1990 • 9 citations

A biastellited marker chromosome in an infant with the caudal regression anomalad

1981 • 9 citations