An Interaction Involving an Arginine Residue in the Cytoplasmic Domain of the 5-HT3A Receptor Contributes to Receptor Desensitization Mechanism

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

Amino Acid Difference Formula to Help Explain Protein Evolution

1974 • 2,255 citations

A study of the ‘desensitization’ produced by acetylcholine at the motor end‐plate

1957 • 1,457 citations

Primary Structure And Functional Expression of the 5HT ₃ Receptor, A Serotonin-gated Ion Channel

1991 • 976 citations

Nicotinic Receptors at the Amino Acid Level

2000 • 795 citations

Desensitized states prolong GABAA channel responses to brief agonist pulses

1995 • 592 citations

The 5-HT3B subunit is a major determinant of serotonin-receptor function

1999 • 555 citations

Volume changes on protein folding

1994 • 551 citations

The impact of receptor desensitization on fast synaptic transmission

1996 • 478 citations

3 Regulation of ligand-gated ion channels by protein phosphorylation

1999 • 297 citations

A cytoplasmic region determines single-channel conductance in 5-HT3 receptors

2003 • 273 citations

5-HT3 receptors mediate rapid responses in cultured hippocampus and a clonal cell line

1988 • 261 citations

The molecular basis of the structure and function of the 5-HT 3 receptor: a model ligand-gated ion channel (Review)

2002 • 188 citations

Differential Composition of 5-Hydroxytryptamine₃Receptors Synthesized in the Rat CNS and Peripheral Nervous System

2002 • 177 citations

Acetylcholine receptor M3 domain: stereochemical and volume contributions to channel gating

1999 • 118 citations

Channel opening locks agonist onto the GABAC receptor

1999 • 115 citations

The role of 5-HT3 receptors in drug dependence

1995 • 112 citations

Ion permeation and conduction in a human recombinant 5‐HT₃ receptor subunit (h5‐HT_3A)

1998 • 109 citations

Common Determinants of Single Channel Conductance within the Large Cytoplasmic Loop of 5-Hydroxytryptamine Type 3 and α4β2 Nicotinic Acetylcholine Receptors

2006 • 95 citations

5-HT3 receptors and neurotransmitter release in the CNS: a nerve ending story?

2000 • 91 citations

Co-expression of the 5-HT3B Serotonin Receptor Subunit Alters the Biophysics of the 5-HT3 Receptor

2003 • 85 citations

Acetylcholine receptor δ subunit mutations underlie a fast-channel myasthenic syndrome and arthrogryposis multiplex congenita

2001 • 76 citations

Molecular determinants of single-channel conductance and ion selectivity in the Cys-loop family: insights from the 5-HT3 receptor

2005 • 74 citations

Acetylcholine receptor δ subunit mutations underlie a fast-channel myasthenic syndrome and arthrogryposis multiplex congenita

2001 • 70 citations

Arginine 222 in the Pre-transmembrane Domain 1 of 5-HT3A Receptors Links Agonist Binding to Channel Gating

2003 • 56 citations

Antibodies against the extracellular domain of the 5-HT3 receptor label both native and recombinant receptors

1999 • 56 citations

Congenital Myasthenic Syndromes: Multiple Molecular Targets at the Neuromuscular Junction

2003 • 54 citations

Open probability of homomeric murine 5‐HT_3A serotonin receptors depends on subunit occupancy

2001 • 51 citations

Modulation of 5-HT3 Receptor-mediated Response and Trafficking by Activation of Protein Kinase C

2003 • 42 citations

The 4′lysine in the putative channel lining domain affects desensitization but not the single‐channel conductance of recombinant homomeric 5‐HT_3A receptors

2000 • 31 citations

Ligand Binding Transmits Conformational Changes across the Membrane‐Spanning Region to the Intracellular Side of the 5‐HT₃ Serotonin Receptor

2005 • 24 citations

A Single Amino-Acid in the TM1 Domain Is an Important Determinant of the Desensitization Kinetics of Recombinant Human and Guinea Pig α-Homomeric 5-Hydroxytryptamine Type 3 Receptors

2001 • 19 citations