TNF-α production by U937 promonocytes is enhanced by factors released from HIV-infected T4 lymphocytes: TNF-α is one of the mediators causing lysis of HIV-infected T4 cells

Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)

1983 • 6,811 citations

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

Frequent Detection and Isolation of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and at Risk for AIDS

1984 • 3,647 citations

Establishment and characterization of a human histiocytic lymphoma cell line (U‐937)

1976 • 2,468 citations

Tumor Necrosis Factor (TNF)

1985 • 1,932 citations

The Biology of Cachectin/TNF -- A Primary Mediator of the Host Response

1989 • 1,679 citations

Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B.

1989 • 1,660 citations

Recombinant Human Tumor Necrosis Factor-α: Effects on Proliferation of Normal and Transformed Cells in Vitro

1985 • 1,596 citations

The Human Immunodeficiency Virus: Infectivity and Mechanisms of Pathogenesis

1988 • 1,496 citations

Cytokine-Induced Expression of HIV-1 in a Chronically Infected Promonocyte Cell Line

1987 • 936 citations

Manganous superoxide dismutase is essential for cellular resistance to cytotoxicity of tumor necrosis factor

1989 • 821 citations

Tumour necrosis factor as immunomodulator and mediator of monocyte cytotoxicity induced by itself, γ-interferon and interleukin-1

1986 • 781 citations

Elevated levels of circulating cachectin/tumor necrosis factor in patients with acquired immunodeficiency syndrome

1988 • 739 citations

Tumor necrosis factor.

1992 • 601 citations

Monokine regulation of human immunodeficiency virus-1 expression in a chronically infected human T cell clone.

1989 • 544 citations

Immunoregulatory activity of recombinant human tumor necrosis factor (TNF)-alpha: induction of TNF receptors on human T cells and TNF-alpha-mediated enhancement of T cell responses.

1987 • 490 citations

Cytokines Alter Production of HIV-1 from Primary Mononuclear Phagocytes

1988 • 486 citations

Antiviral effects of recombinant tumour necrosis factor in vitro

1986 • 392 citations

Cell-associated tumor necrosis factor (TNF) as a killing mechanism of activated cytotoxic macrophages.

1987 • 361 citations

Replication of human immunodeficiency virus in monocytes. Granulocyte/macrophage colony-stimulating factor (GM-CSF) potentiates viral production yet enhances the antiviral effect mediated by 3'-azido-2'3'-dideoxythymidine (AZT) and other dideoxynucleoside congeners of thymidine.

1989 • 293 citations

Studies on the anti-tumor efficacy of systemically administered recombinant tumor necrosis factor against several murine tumors in vivo.

1987 • 292 citations

Single amino-acid changes in HIV envelope affect viral tropism and receptor binding

1989 • 270 citations

Tumor necrosis factor and lymphotoxin induce differentiation of human myeloid cell lines in synergy with immune interferon.

1986 • 261 citations

Spontaneous cytotoxicity and tumor necrosis factor production by peripheral blood monocytes from AIDS patients.

1988 • 187 citations

Identity of differentiation inducing factor and tumour necrosis factor

1986 • 181 citations

Human granulocyte-macrophage colony-stimulating factor induces expression of the tumor necrosis factor gene by the U937 cell line and by normal human monocytes.

1987 • 178 citations

Expression of functional IL 2 receptors by lipopolysaccharide and interferon-gamma stimulated human monocytes.

1987 • 176 citations

Common Region on Chromosome 14 in T-Cell Leukemia and Lymphoma

1984 • 174 citations

Production of tumor necrosis factor alpha and interleukin 1 beta by monocytic cells infected with human immunodeficiency virus.

1989 • 172 citations

Macrophages and the human immunodeficiency virus

1990 • 169 citations

Preparations of lymphotoxin induce resistance to their own cytotoxic effect.

1984 • 168 citations

Production of interleukin-1 alpha, interleukin-1 beta and tumor necrosis factor by human mononuclear cells stimulated with granulocyte- macrophage colony-stimulating factor [see comments]

1988 • 165 citations

Human Immunodeficiency Viruses and the Pathogenesis of AIDS

1989 • 153 citations

Characterization of the RNA dependent DNA polymerase of a new human T lymphotropic retrovirus (lymphadenopathy associated virus)

1984 • 151 citations

Tumour necrosis factors (α, β) induced by HIV-1 in peripheral blood mononuclear cells potentiate virus replication

1990 • 145 citations

In vitro modification of human immunodeficiency virus infection by granulocyte-macrophage colony-stimulating factor and gamma interferon.

1986 • 133 citations

In vitro anti-human immunodeficiency virus activities of tumor necrosis factor-alpha and interferon-gamma.

1988 • 132 citations

Production of tumour necrosis factor-alpha (TNF-alpha) and interleukin-1 (IL-1) in patients with AIDS. Enhanced level of TNF-alpha is related to a higher cytotoxic activity.

1989 • 112 citations

Tumor necrosis factor and HIV P24 antigen levels in serum of HIV-infected populations.

1988 • 109 citations

Production of interleukin-1 alpha, interleukin-1 beta and tumor necrosis factor by human mononuclear cells stimulated with granulocyte- macrophage colony-stimulating factor [see comments]

1988 • 103 citations

Recombinant tumor necrosis factor: Species specificity for a variety of human and murine transformed cell lines

1986 • 100 citations

Macrophage-mediated cytotoxicity: role of a soluble macrophage cytotoxic factor similar to lymphotoxin and tumor necrosis factor.

1983 • 99 citations

Generation and characterization of a lipopolysaccharide-induced and serum-derived cytotoxic factor for tumor cells

1980 • 88 citations

Synergistic activity of granulocyte-macrophage colony-stimulating factor and 3'-azido-3'-deoxythymidine against human immunodeficiency virus in vitro

1987 • 87 citations

Differential gene expression of IFN-alpha and tumor necrosis factor-alpha in peripheral blood mononuclear cells from patients with AIDS related complex and AIDS.

1990 • 82 citations

Cellular immunology of HIV-infection.

1988 • 81 citations

Cytotoxicity of human macrophages for tumor cells: enhancement by bacterial lipopolysaccharides (LPS).

1980 • 70 citations

Human immunodeficiency virus-1 infection of macrophages in vitro neither induces tumor necrosis factor (TNF)/cachectin gene expression nor alters TNF/cachectin induction by lipopolysaccharide.

1990 • 68 citations

Studies on the mechanism of natural killer cell-mediated cytotoxicity. VII. functional comparison of human natural killer cytotoxic factors with recombinant lymphotoxin and tumor necrosis factor.

1987 • 67 citations

Tumor necrosis factor-induced changes of gene expression in U937 cells. Differentiation-dependent plasticity of the responsive state.

1988 • 54 citations

Recombinant human granulocyte‐macrophage colony‐stimulating factor induces secretion of autoinhibitory monokines by U‐937 cells

1988 • 42 citations

Human immunodeficiency virus type 1 infection of U937 cells promotes cell differentiation and a new pathway of viral assembly

1990 • 35 citations

Cytotoxins (tumour necrosis factor, lymphotoxin and others): molecular and functional characteristics and interactions with interferons.

1986 • 32 citations

Lymphotoxin production in AIDS

1986 • 23 citations

Expression of human immunodeficiency virus long terminal repeat in the human promonocyte cell line U937: Effect of endotoxin and cytokines

1990 • 12 citations

Involvement of cytotoxins in the immune response to viral infection

1985 • 6 citations