Human Immunodeficiency Viruses and the Pathogenesis of AIDS

Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)

1983 • 6,811 citations

Frequent Detection and Isolation of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and at Risk for AIDS

1984 • 3,647 citations

An inducible transcription factor activates expression of human immunodeficiency virus in T cells

1987 • 2,149 citations

The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain

1986 • 2,020 citations

The Role of Mononuclear Phagocytes in HTLV-III/LAV Infection

1986 • 1,828 citations

Detection of AIDS Virus in Macrophages in Brain Tissue from AIDS Patients with Encephalopathy

1986 • 1,694 citations

Isolation of Lymphocytopathic Retroviruses from San Francisco Patients with AIDS

1984 • 1,429 citations

Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro

1988 • 1,371 citations

Isolation of a New Human Retrovirus from West African Patients with AIDS

1986 • 1,260 citations

The Brain in AIDS: Central Nervous System HIV-1 Infection and AIDS Dementia Complex

1988 • 1,244 citations

CD8 ⁺ Lymphocytes Can Control HIV Infection in Vitro by Suppressing Virus Replication

1986 • 1,010 citations

DNA Amplification for Direct Detection of HIV-1 in DNA of Peripheral Blood Mononuclear Cells

1988 • 979 citations

Selective Tropism of Lymphadenopathy Associated Virus (LAV) for Helper-Inducer T Lymphocytes

1984 • 976 citations

Role of the HTLV-III/LAV envelope in syncytium formation and cytopathicity

1986 • 804 citations

HIV-specific cytotoxic T lymphocytes in seropositive individuals

1987 • 797 citations

Efficient isolation and propagation of human immunodeficiency virus on recombinant colony-stimulating factor 1-treated monocytes.

1988 • 785 citations

Identification and characterization of conserved and variable regions in the envelope gene of HTLV-III/LAV, the retrovirus of AIDS

1986 • 780 citations

Astrocytes present myelin basic protein to encephalitogenic T-cell lines

1984 • 773 citations

Detection of lymphocytes expressing human T-lymphotropic virus type III in lymph nodes and peripheral blood from infected individuals by in situ hybridization.

1986 • 740 citations

Biologic Features of HIV-1 That Correlate with Virulence in the Host

1988 • 679 citations

Evidence for a role of virulent human immunodeficiency virus (HIV) variants in the pathogenesis of acquired immunodeficiency syndrome: studies on sequential HIV isolates

1989 • 662 citations

Differential syncytium-inducing capacity of human immunodeficiency virus isolates: frequent detection of syncytium-inducing isolates in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex

1988 • 621 citations

Neuronal cell killing by the envelope protein of HIV and its prevention by vasoactive intestinal peptide

1988 • 616 citations

Induction of CD4-dependent cell fusion by the HTLV-III/LAV envelope glycoprotein

1986 • 593 citations

AIDS virus-specific cytotoxic T lymphocytes in lung disorders

1987 • 539 citations

HIV F/3' orf encodes a phosphorylated GTP-binding protein resembling an oncogene product

1987 • 523 citations

Predictors of the Acquired Immunodeficiency Syndrome Developing in a Cohort of Seropositive Homosexual Men

1987 • 520 citations

Fine structure of human immunodeficiency virus (HIV) and immunolocalization of structural proteins

1987 • 517 citations

Antibody-Enhanced Infection by HIV-1 Via Fc Receptor-Mediated Entry

1988 • 462 citations

Epidemiology of HIV Infection and AIDS in the United States

1988 • 450 citations

HIV-1 gag-specific cytotoxic T lymphocytes defined with recombinant vaccinia virus and synthetic peptides

1988 • 447 citations

Distinct replicative and cytopathic characteristics of human immunodeficiency virus isolates

1988 • 443 citations

In vivo effector function of influenza virus-specific cytotoxic T lymphocyte clones is highly specific.

1984 • 439 citations

Detection of a fusion peptide sequence in the transmembrane protein of human immunodeficiency virus

1987 • 433 citations

Human Immunodeficiency Virus Infection among Men with Sexually Transmitted Diseases

1988 • 404 citations

Infection and Replication of HIV-1 in Purified Progenitor Cells of Normal Human Bone Marrow

1988 • 375 citations

Sexual practices and risk of infection by the human immunodeficiency virus. The San Francisco Men's Health Study

1987 • 374 citations

Analysis of host-virus interactions in AIDS with anti-gp120 T cell clones: Effect of HIV sequence variation and a mechanism for CD4+ cell depletion

1988 • 372 citations

Nef Protein of HIV-1 Is a Transcriptional Repressor of HIV-1 LTR

1988 • 366 citations

ANTIBODY-DEPENDENT ENHANCEMENT OF HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 INFECTION

1988 • 362 citations

Persistent HIV antigenaemia and decline of HIV core antibodies associated with transition to AIDS.

1986 • 342 citations

The Fc and not CD4 Receptor Mediates Antibody Enhancement of HIV Infection in Human Cells

1989 • 328 citations

Human Immunodeficiency Virus Type 2 Infection Associated with AIDS in West Africa

1987 • 319 citations

Mutational analysis of the human immunodeficiency virus: the orf-B region down-regulates virus replication.

1987 • 310 citations

Interactions of cellular proteins involved in the transcriptional regulation of the human immunodeficiency virus.

1987 • 306 citations

Variable and conserved neutralization antigens of human immunodeficiency virus

1986 • 296 citations

Risk of Transmitting the Human Immunodeficiency Virus, Cytomegalovirus, and Hepatitis B Virus to Health Care Workers Exposed to Patients with AIDS and AIDS-Related Conditions

1987 • 295 citations

HIV-1 Reverse Transcriptase Is a Target for Cytotoxic T Lymphocytes in Infected Individuals

1988 • 270 citations

Induction of HTLV-III/LAV from a Nonvirus-Producing T-Cell Line: Implications for Latency

1986 • 264 citations

Long-Term Evaluation of HIV Antigen and Antibodies to p24 and gp41 in Patients with Hemophilia

1987 • 245 citations

Productive, persistent infection of human colorectal cell lines with human immunodeficiency virus

1987 • 235 citations

Genomic diversity of the acquired immune deficiency syndrome virus HTLV-III: different viruses exhibit greatest divergence in their envelope genes.

1985 • 230 citations

Differential susceptibility to the acquired immunodeficiency syndrome retrovirus in cloned cells of human leukemic T-cell line Molt-4

1986 • 222 citations

A diffusible lymphokine produced by CD8+ T lymphocytes suppresses HIV replication.

1989 • 221 citations

HTLV-III Exposure during Cardiopulmonary Resuscitation

1985 • 197 citations

Amplification of HTLV-III/LAV infection by antigen-induced activation of T cells and direct suppression by virus of lymphocyte blastogenic responses.

1987 • 194 citations

An AIDS-related cytotoxic autoantibody reacts with a specific antigen on stimulated CD4+ T cells

1987 • 191 citations

Human immunodeficiency virus infection of monocytic and T-lymphocytic cells: Receptor modulation and differentiation induced by phorbol ester

1987 • 187 citations

Infection by the Retrovirus Associated with the Acquired Immunodeficiency Syndrome

1985 • 179 citations

Antigenemia and Antibody Titers to Core and Envelope Antigens in AIDS, AIDS-Related Complex, and Subclinical Human Immunodeficiency Virus Infection

1987 • 175 citations

Loss of Human Immunodeficiency Virus Type 1 (HIV-I) Antibodies with Evidence of Viral Infection in Asymptomatic Homosexual Men

1988 • 165 citations

Complete identification of endocrine cells in the gastrointestinal tract using semithin-thin sections to identify motilin cells in human and animal intestine.

1975 • 165 citations

Human immunodeficiency virus infection of T cells and monocytes proceeds via receptor-mediated endocytosis.

1988 • 163 citations

Suppression of simian immunodeficiency virus replication in vitro by CD8+ lymphocytes.

1988 • 157 citations

Sera from HTLV-III/LAV antibody-positive individuals mediate antibody-dependent cellular cytotoxicity against HTLV-III/LAV-infected T cells.

1987 • 154 citations

A major mechanism of human immunodeficiency virus-induced cell killing does not involve cell fusion

1987 • 154 citations

Quantitative Immunocytofluorographic Analysis of CD4 Surface Antigen Expression and HIV Infection of Human Peripheral Blood Monocyte/Macrophages

1987 • 153 citations

Persistent Noncytopathic Infection of Normal Human T Lymphocytes with AIDS-Associated Retrovirus

1985 • 151 citations

Mysteries of HIV: challenges for therapy and prevention

1988 • 148 citations

ACQUIRED IMMUNODEFICIENCY SYNDROME IS AN OPPORTUNISTIC INFECTION AND KAPOSI'S SARCOMA RESULTS FROM SECONDARY IMMUNE STIMULATION

1983 • 144 citations

West African HIV-2-Related Human Retrovirus with Attenuated Cytopathicity

1988 • 141 citations

Anti-lymphocyte antibodies in patients with the acquired immune deficiency syndrome

1985 • 129 citations

Stimulatory and inhibitory influences of human immunodeficiency virus on normal B lymphocytes.

1986 • 120 citations

Characterization of a Noncytopathic HIV-2 Strain with Unusual Effects on CD4 Expression

1988 • 119 citations

CELLULAR ANTI-GP120 CYTOLYTIC REACTIVITIES IN HIV-1 SEROPOSITIVE INDIVIDUALS

1988 • 119 citations

The Transmission of AIDS: The Case of the Infected Cell

1988 • 108 citations

Minireview: Induction of Expression of HIV in Latently or Chronically Infected Cells

1989 • 107 citations

Molecular biology of HIV

1988 • 106 citations

Development and Testing of AIDS Vaccines

1988 • 106 citations

Low fidelity of cell-free DNA synthesis by reverse transcriptase of human immunodeficiency virus

1988 • 105 citations

Acquired immunodeficiency syndrome-associated arthritis

1988 • 104 citations

Methylation as a modulator of expression of human immunodeficiency virus

1987 • 96 citations

CD8+ T lymphocyte control of HIV replication in cultured CD4+ cells varies among infected individuals

1989 • 93 citations

SIMULTANEOUS ISOLATION OF HIV-1 AND HIV-2 FROM AN AIDS PATIENT

1988 • 87 citations

ANTIBODY-DEPENDENT ENHANCEMENT OF HIV INFECTION

1988 • 81 citations

THE EPSTEIN–BARR VIRUS AS A MODEL OF VIRUS–HOST INTERACTIONS

1985 • 80 citations

Antibodies to human immunodeficiency virus in human sera induce cell-mediated lysis of human immunodeficiency virus-infected cells.

1987 • 71 citations

Lymphocytotoxic antibodies in the acquired immune deficiency syndrome (AIDS)

1984 • 68 citations

MT-4 plaque formation can distinguish cytopathic subtypes of the human immunodeficiency virus (HIV)

1988 • 63 citations

Human immunodeficiency virus-associated changes in signal transduction

1987 • 59 citations

A Six-Year Follow-up of HIV-Infected Homosexual Men With Lymphadenopathy

1988 • 58 citations

HIV heterogeneity and viral pathogenesis

1988 • 46 citations

Biologic and molecular properties of the AIDS-associated retrovirus that affect antiviral therapy

1987 • 42 citations

Human Immunodeficiency Virus Recovery from Bronchoalveolar Lavage Fluid in Patients with AIDS

1988 • 41 citations

The multifaceted retrovirus.

1986 • 39 citations

Replication of the human immunodeficiency virus 1 and impaired differentiation of T cells after in vitro infection of bone marrow immature T cells.

1989 • 29 citations

The Human Immunodeficiency Virus and its Pathogenesis

1988 • 9 citations

The human immunodeficiency viruses. Detection and pathogenesis.

1989 • 7 citations

The molecular biology of HIV infection: clues for possible therapy.

1989 • 2 citations