Macrophage-mediated cytotoxicity: role of a soluble macrophage cytotoxic factor similar to lymphotoxin and tumor necrosis factor.

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

Extracellular cytolysis by activated macrophages and granulocytes. II. Hydrogen peroxide as a mediator of cytotoxicity.

1979 • 538 citations

Macrophages as a source of tumoricidal activity (tumor-necrotizing factor)

1980 • 398 citations

Purification and physico-chemical characterization of rabbit tumor necrosis factor.

1980 • 386 citations

Activated macrophages kill tumour cells by releasing arginase

1978 • 307 citations

Effector mechanisms of cytolytically activated macrophages. II. Secretion of a cytolytic factor by activated macrophages and its relationship to secreted neutral proteases.

1980 • 206 citations

Tumour-necrosis factor from the rabbit. I. Mode of action, specificity and physicochemical properties

1978 • 172 citations

Possible requirement of internalization in the mechanism of in vitro cytotoxicity in tumor necrosis serum.

1981 • 160 citations

Tumour-necrosis factor from the rabbit. II. Production by monocytes

1978 • 116 citations

Production of the complement cleavage product, C3a, by activated macrophages and its tumorolytic effects.

1978 • 111 citations

Preliminary characterization of the tumor cell cytotoxin in tumor necrosis serum.

1981 • 94 citations

Generation and characterization of a lipopolysaccharide-induced and serum-derived cytotoxic factor for tumor cells

1980 • 88 citations

Factors in Delayed Sensitivity: Lymphocyte and Macrophage Cytotoxins in the Tuberculin Reaction

1969 • 73 citations

The in vitro induction and release of a cell toxin by immune C57B1/6 mouse peritoneal macrophages

1972 • 67 citations

Inhibition of nonspecific tumoricidal activity by activated macrophages with antiserum against a soluble cytotoxic factor

1981 • 62 citations

Effect of anti-lymphotoxin on cell-mediated cytotoxicity

1976 • 55 citations

Cytotoxic activity of lymphocytes. V. Role of soluble toxin in macrophage-inhibited cultures of tumor cells.

1975 • 51 citations

Studies on Lymphokines: The Production of Antibody to Guinea Pig Lymphotoxin and its Use to Distinguish Lymphotoxin from Migration Inhibitory Factor and Mitogenic Factor

1975 • 43 citations

Effect of human monocyte killing of tumour cells of antibody raised against an extracellular monocyte cytotoxin.

1983 • 42 citations

Active and passive immunity against Pseudomonas aeruginosa with a ribosomal vaccine and antiserum in C3H/HeJ mice.

1983 • 42 citations

Mechanism of Nonspecific Macrophage-Mediated Cytotoxicity: Evidence for Lack of Dependence upon Oxygen

1978 • 39 citations

Activation of macrophages for tumor cell cytotoxicity: identification of indomethacin sensitive and insensitive pathways.

1981 • 38 citations

Lymphotoxin. A review and analysis.

1976 • 35 citations

Inhibition of Human Lymphocyte-Mediated Mitogen-Induced Cytotoxicity of Murine L-929 Cells by Heterologous Anti-Human Lymphotoxin Antisera In Vitro

1977 • 34 citations

The LT system in experimental animals. III. Physicochemical characteristics and relationships of lymphotoxin (LT) molecules released in vitro by activated lymphoid cells from several animal species.

1979 • 30 citations

Mechanisms of lymphocyte-mediated cytotoxicity. I. The effects of anti-human lymphotoxin antisera on the cytolysis of allogeneic B cell lines by MLC-sensitized human lymphocytes in vitro.

1981 • 29 citations

The Molecular Dimensions of Guinea Pig Lymphotoxin

1974 • 28 citations

PURIFICATION AND CHARACTERIZATION OF GUINEA PIG LYMPHOTOXIN PRODUCED BY LYMPH NODE CELLS STIMULATED BY PHYTOHEMAGGLUTININ

1975 • 20 citations

Functional heterogeneity among peritoneal macrophages

1980 • 18 citations

Inability of the C3a anaphylatoxin to promote cellular lysis

1980 • 18 citations

Studies on the mechanism of action of guinea pig lymphotoxin. I. Membrane active substances prevent target cell lysis by lymphotoxin.

1978 • 17 citations

CELLULAR CYTOTOXICITY INDUCED BY VARIOUS LECTINS AND MITOGENS

1978 • 14 citations

Human T-cell-mediated cytotoxicity: Role of subsets and neutralization of cytotoxicity by anti-α-lymphotoxin serum

1982 • 12 citations

Role of soluble cytotoxins in cell-mediated immunity.

1973 • 10 citations