Membrane phospholipids, lipoxidative damage and molecular integrity: A causal role in aging and longevity

Free radicals in biology and medicine

1991 • 17,840 citations

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

1991 • 6,550 citations

Membrane lipids: where they are and how they behave

2008 • 6,294 citations

Free radicals in biology and medicine

1985 • 2,999 citations

The Biologic Clock: The Mitochondria?

1972 • 1,912 citations

Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators

1998 • 1,870 citations

Structure, function and evolution of glutathione transferases: implications for classification of non-mammalian members of an ancient enzyme superfamily

2001 • 1,485 citations

Biochemistry of Lipids, Lipoproteins and Membranes

2021 • 1,420 citations

Genetic pathways that regulate ageing in model organisms

2000 • 1,341 citations

Overview of caloric restriction and ageing

2005 • 1,040 citations

Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins

2004 • 1,019 citations

STRUCTURE, FUNCTION, AND DIETARY REGULATION OF Δ6, Δ5, AND Δ9 DESATURASES

2004 • 993 citations

MOLECULAR BASIS FOR MEMBRANE PHOSPHOLIPID DIVERSITY: Why Are There So Many Lipids?

1997 • 956 citations

Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers

2004 • 948 citations

Mitochondrial role in cell aging

1980 • 919 citations

Life and Death: Metabolic Rate, Membrane Composition, and Life Span of Animals

2007 • 863 citations

Accumulation of Maillard reaction products in skin collagen in diabetes and aging.

1993 • 764 citations

Biological significance of phospholipid hydroperoxide glutathione peroxidase (PHGPx, GPx4) in mammalian cells

2003 • 718 citations

Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging.

1997 • 701 citations

Cardiolipins and biomembrane function

1992 • 597 citations

A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling

2003 • 587 citations

N ε-(Carboxyethyl)lysine, a product of the chemical modification of proteins by methylglyoxal, increases with age in human lens proteins

1997 • 580 citations

Advanced lipid peroxidation end products in oxidative damage to proteins. Potential role in diseases and therapeutic prospects for the inhibitors

2007 • 578 citations

Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products

2004 • 561 citations

Oxy radicals, lipid peroxidation and DNA damage

2002 • 556 citations

Nuclear Factor κB Signaling in Atherogenesis

2005 • 545 citations

Vitamin E and its function in membranes

1999 • 537 citations

A study of the reactivity of HO2/O2- with unsaturated fatty acids.

1983 • 519 citations

Maillard reaction products in tissue proteins: New products and new perspectives

2003 • 513 citations

Dynamic, yet structured: The cell membrane three decades after the Singer–Nicolson model

2003 • 513 citations

The Naked Mole-Rat: A New Long-Living Model for Human Aging Research

2005 • 443 citations

Lipofuscin

2003 • 403 citations

Effect of unsaturated acids on membrane structure and enzyme kinetics

1984 • 382 citations

Alterations in mitochondrial membrane fluidity by lipid peroxidation products

1994 • 367 citations

Role of the Maillard Reaction in Aging of Tissue Proteins

1998 • 357 citations

Reactive oxygen species affect mitochondrial electron transport complex I activity through oxidative cardiolipin damage

2002 • 353 citations

Biochemistry of Lipids, Lipoproteins and Membranes

1996 • 352 citations

Polyunsaturated fatty acid synthesis: what will they think of next?

2002 • 339 citations

Rate And Magnitude Of Age Pigment Accumulation In The Human Myocardium

1959 • 336 citations

The Nrf2–Keap1 defence pathway: Role in protection against drug-induced toxicity

2007 • 324 citations

Age-related accumulation of Maillard reaction products in human articular cartilage collagen

2000 • 314 citations

Regulation of SREBP Processing and Membrane Lipid Production by Phospholipids in Drosophila

2002 • 305 citations

Age-dependent accumulation of N.epsilon.-(carboxymethyl)lysine and N.epsilon.-(carboxymethyl)hydroxylysine in human skin collagen

1991 • 298 citations

Intervention strategies to inhibit protein carbonylation by lipoxidation‐derived reactive carbonyls

2006 • 284 citations

Endogenous Reactive Intermediates as Modulators of Cell Signaling and Cell Death

2006 • 282 citations

Influences of Dietary Restriction and Age on Liver Enzyme Activities and Lipid Peroxidation in Mice

1987 • 280 citations

In vivospectrofluorimetry reveals endogenous biomarkers that report healthspan and dietary restriction inCaenorhabditis elegans

2005 • 267 citations

Cardiac reperfusion injury: Aging, lipid peroxidation, and mitochondrial dysfunction

1998 • 260 citations

Lipid peroxidation and cell cycle signaling: 4-hydroxynonenal, a key molecule in stress mediated signaling.

2003 • 259 citations

Membrane Fatty Acid Unsaturation, Protection against Oxidative Stress, and Maximum Life Span

2002 • 258 citations

Mitochondrial oxidative stress, aging and caloric restriction: The protein and methionine connection

2006 • 248 citations

Longer Life Spans and Delayed Maturation in Wild-Derived Mice

2002 • 247 citations

Is the Mitochondrial Free Radical Theory of Aging Intact?

2006 • 245 citations

Changes in superoxide radical and lipid peroxide formation in the brain, heart and liver during the lifetime of the rat

1987 • 241 citations

Oxidation of glycated proteins: age-dependent accumulation of N.epsilon.-(carboxymethyl)lysine in lens proteins

1989 • 239 citations

Vitamins A and E: metabolism, roles and transfer to offspring

2005 • 238 citations

Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins

2006 • 229 citations

Mitochondrial membrane peroxidizability index is inversely related to maximum life span in mammals

1998 • 225 citations

Effect of Antioxidants and Nutrients on Lipid Peroxidation Fluorescent Products and Aging Parameters in the Mouse

1973 • 224 citations

The Membranes of Cells

2016 • 224 citations

Autoxidation of fats and related substances

1954 • 218 citations

Mitochondrial Oxygen Consumption and Reactive Oxygen Species Production are Independently Modulated: Implications for Aging Studies

2007 • 212 citations

Allometry of mitochondrial proton leak: influence of membrane surface area and fatty acid composition

1996 • 207 citations

Effect of Dietary Restriction on the Age-Dependent Changes in the Expression of Antioxidant Enzymes in Rat Liver

1990 • 206 citations

The proteasomal system and HNE-modified proteins

2003 • 196 citations

Effect of age-related lipid peroxidation on membrane fluidity and phospholipase A2: Modulation by dietary restriction

1992 • 190 citations

Oxidative damage and phospholipid fatty acyl composition in skeletal muscle mitochondria from mice underexpressing or overexpressing uncoupling protein 3

2002 • 187 citations

Protein Crosslinking by the Maillard Reaction: Dicarbonyl-Derived Imidazolium Crosslinks in Aging and Diabetes

1999 • 184 citations

Insulin/IGF signalling and ageing: seeing the bigger picture

2001 • 174 citations

Modulation of Membrane Phospholipid Fatty Acid Composition by Age and Food Restriction

1993 • 164 citations

Influence of age, exercise, and dietary restriction on oxidative stress in rats

1996 • 164 citations

4-Hydroxynonenal Prevents NF-κB Activation and Tumor Necrosis Factor Expression by Inhibiting IκB Phosphorylation and Subsequent Proteolysis

1999 • 162 citations

Age-related changes in lipid peroxidation as measured by ethane, ethylene, butane and pentane in respired gases of rats

1980 • 162 citations

Age-dependence of molecular and functional changes in biological membrane properties

1980 • 157 citations

Membrane phospholipid composition may contribute to exceptional longevity of the naked mole-rat (Heterocephalus glaber): A comparative study using shotgun lipidomics

2007 • 157 citations

8. Stress-induced activation of the heat-shock response: cell and molecular biology of heat-shock factors

1999 • 154 citations

Brain synaptosomal aging: Free radicals and membrane fluidity

1995 • 147 citations

Proton conductance and fatty acyl composition of liver mitochondria correlates with body mass in birds

2003 • 145 citations

Low prevalences of coronary heart disease (CHD), psoriasis, asthma and rheumatoid arthritis in Eskimos: Are they caused by high dietary intake of eicosapentaenoic acid (EPA), a genetic variation of essential fatty acid (EFA) metabolism or a combination of both?

1987 • 142 citations

Activation of EGF receptor by oxidized LDL

1998 • 141 citations

Direct Measurement of Nitric Oxide and Oxygen Partitioning into Liposomes and Low Density Lipoprotein

2005 • 139 citations

Anti-lipoperoxidation action of food restriction

1987 • 139 citations

Low fatty acid unsaturation protects against lipid peroxidation in liver mitochondria from long-lived species: the pigeon and human case

1996 • 139 citations

The acyl composition of mammalian phospholipids: an allometric analysis

2002 • 134 citations

A low degree of fatty acid unsaturation leads to lower lipid peroxidation and lipoxidation-derived protein modification in heart mitochondria of the longevous pigeon than in the short-lived rat

1999 • 132 citations

Lipofuscin Pigment Accumulation and Distribution in Five Rat Organs as a Function of Age

1968 • 132 citations

Peroxide-producing potential of tissues: inverse correlation with longevity of mammalian species.

1985 • 131 citations

Highly resistant macromolecular components and low rate of generation of endogenous damage: Two key traits of longevity

2007 • 129 citations

Deacylation and Reacylation of Neural Membrane Glycerophospholipids: A Matter of Life and Death

2000 • 127 citations

Caloric Restriction Decreases Age-Dependent Accumulation of the Glycoxidation Products, Nisin-(Carboxymethyl)lysine and Pentosidine, in Rat Skin Collagen

1995 • 126 citations

Double bond content of phospholipids and lipid peroxidation negatively correlate with maximum longevity in the heart of mammals

2000 • 120 citations

Extended longevity of queen honey bees compared to workers is associated with peroxidation-resistant membranes

2007 • 119 citations

Oxidative, glycoxidative and lipoxidative damage to rat heart mitochondrial proteins is lower after 4 months of caloric restriction than in age-matched controls

2002 • 119 citations

Methylglyoxal induces advanced glycation end product (AGEs) formation and dysfunction of PDGF receptor‐β: implications for diabetic atherosclerosis

2007 • 116 citations

Changes in rat liver mitochondria with aging

2003 • 116 citations

Dietary Protein Restriction Decreases Oxidative Protein Damage, Peroxidizability Index, and Mitochondrial Complex I Content in Rat Liver

2007 • 114 citations

Oxidation-Resistant Membrane Phospholipids Can Explain Longevity Differences Among the Longest-Living Rodents and Similarly-Sized Mice

2006 • 113 citations

Lipid Asymmetry of the Eukaryotic Plasma Membrane: Functions and Related Enzymes

2006 • 112 citations

Effect of Diabetes and Aging on Carboxymethyllysine Levels in Human Urine

1991 • 112 citations

Acyl composition of muscle membranes varies with body size in birds

2002 • 111 citations

Forty percent and eighty percent methionine restriction decrease mitochondrial ROS generation and oxidative stress in rat liver

2008 • 109 citations

Rate of Accumulation of Cardiac Lipofuscin in the Aging Canine

1968 • 105 citations

Age-related accumulation of Maillard reaction products in human articular cartilage collagen

2000 • 104 citations

Modulation of cardiac mitochondrial membrane fluidity by age and calorie intake

1999 • 100 citations

Stimulation of HeLa cell growth by physiological concentrations of 4‐hydroxynonenal

1993 • 96 citations

Advanced Glycation End Product Precursors Impair Epidermal Growth Factor Receptor Signaling

2002 • 94 citations

Effect of Diet Restriction on Some Biochemical Parameters Related to Aging in Mice

1983 • 94 citations

NF‐κB activation mechanism of 4‐hydroxyhexenal via NIK/IKK and p38 MAPK pathway

2004 • 92 citations

Redox Signaling and Regulation in Biology and Medicine

2009 • 91 citations

Age related changes in the lipids of the microsomal and the mitochondrial membranes of rat liver and kidney

1977 • 90 citations

Low Fatty Acid Unsaturation: A Mechanism for Lowered Lipoperoxidative Modification of Tissue Proteins in Mammalian Species With Long Life Spans

2000 • 88 citations

Regional difference of ROS generation, lipid peroxidaton, and antioxidant enzyme activity in rat brain and their dietary modulation

1999 • 87 citations

Are lipid peroxidation processes induced by changes in the cell wall structure and how are these processes connected with diseases?

2002 • 84 citations

Proinflammatory Effects of Advanced Lipoxidation End Products in Monocytes

2007 • 84 citations

Methionine Restriction Decreases Endogenous Oxidative Molecular Damage and Increases Mitochondrial Biogenesis and Uncoupling Protein 4 in Rat Brain

2007 • 82 citations

Heart fatty acid unsaturation and lipid peroxidation, and aging rate, are lower in the canary and the parakeet than in the mouse

1999 • 78 citations

On the origin of lipid asymmetry: the flip side of ion transport

2007 • 77 citations

Aging and Caloric Restriction Affect Mitochondrial Respiration and Lipid Membrane Status: An Electron Paramagnetic Resonance Investigation

1997 • 76 citations

LIPOFUSCIN (AGING) PIGMENT GRANULES OF THE NEWBORN HUMAN LIVER

1969 • 76 citations

Age-related changes in linoleate and α-linolenate desaturation by rat liver microsomes

1989 • 76 citations

Inhibition of NFκB Activation and IL-8 Expression in Human Bronchial Epithelial Cells by Acrolein

2004 • 76 citations

Spectrophotofluorometric and Electron Microscopic Study of Lipofuscin Accumulation in the Testis of Aging Mice

1978 • 75 citations

Extended longevity of wild-derived mice is associated with peroxidation-resistant membranes

2006 • 74 citations

Protein and lipid oxidative damage and complex I content are lower in the brain of budgerigar and canaries than in mice. Relation to aging rate

2005 • 72 citations

Effect of ageing and caloric restriction on specific markers of protein oxidative damage and membrane peroxidizability in rat liver mitochondria

2004 • 71 citations

Food Restriction Suppresses an Age-Dependent Increase in the Exhalation Rate of Pentane From Rats: A Longitudinal Study

1993 • 71 citations

Modification of the longevity-related degree of fatty acid unsaturation modulates oxidative damage to proteins and mitochondrial DNA in liver and brain

2004 • 70 citations

Superoxide radical formation and associated biochemical alterations in the plasma membrane of brain, heart, and liver during the lifetime of the rat

1992 • 68 citations

4-hydroxynonenal and regulation of cell cycle: effects on the pRb/E2F pathway

2004 • 68 citations

Effect of insulin and growth hormone on rat heart and liver oxidative stress in control and caloric restricted animals

2005 • 66 citations

Correlation of fatty acid unsaturation of the major liver mitochondrial phospholipid classes in mammals to their maximum life span potential

2001 • 65 citations

�ber das Lipofuscin der Leber

1953 • 65 citations

Mildly Oxidized LDL Induces Activation of Platelet-Derived Growth Factor β-Receptor Pathway

2001 • 61 citations

Protein methionine content and MDA-lysine adducts are inversely related to maximum life span in the heart of mammals

2005 • 59 citations

Age-dependent changes in lipid peroxide levels in peripheral organs, but not in brain, in senescence-accelerated mice

2000 • 58 citations

Aging and food restriction: Effect on lipids of cerebral cortex

1991 • 56 citations

Aging Increases N epsilon -(Carboxymethyl)lysine and Caloric Restriction Decreases N epsilon -(Carboxyethyl)lysine and N epsilon -(Malondialdehyde)lysine in Rat Heart Mitochondrial Proteins

2002 • 56 citations

Effect of 8.5% and 25% caloric restriction on mitochondrial free radical production and oxidative stress in rat liver

2007 • 56 citations

Oxidative Status in Senescence-Accelerated Mice

1996 • 55 citations

Effect of the degree of fatty acid unsaturation of rat heart mitochondria on their rates of H2O2 production and lipid and protein oxidative damage

2001 • 54 citations

Membrane alteration as a basis of aging and the protective effects of calorie restriction

2005 • 51 citations

Effect of dietary restriction on age‐related increase of liver susceptibility to peroxidation in rats

2001 • 49 citations

Effects of caloric restriction on age-related oxidative modifications of macromolecules and lymphocyte proliferation in rats

1995 • 48 citations

Determining radical penetration of lipid bilayers with new lipophilic spin traps

2008 • 46 citations

Some biochemical parameters of ageing in relation to dietary protein

1983 • 44 citations

Pulmonary pentane excretion increases with age in healthy subjects

1993 • 41 citations

Effects of peroxidative stress and age on the concentration of a deoxyguanosine-malondialdehyde adduct in rat DNA

1995 • 40 citations

Dietary restriction reduces fluorescent age pigment accumulation in mice

1981 • 40 citations

Protein nonenzymatic modifications and proteasome activity in skeletal muscle from the short-lived rat and long-lived pigeon

2004 • 40 citations

Unsaturated fatty acids intake and all-causes mortality: a 8.5-year follow-up of the Italian Longitudinal Study on Aging

2005 • 37 citations

Effects of oxidative stress on glycerolipid acyl turnover in rat hepatocytes

1997 • 34 citations

Chlamydia pneumoniae activates IKK/IκB-mediated signaling, which is inhibited by 4-HNE and following primary exposure

2002 • 33 citations

Reversal by aminoguanidine of the age-related increase in glycoxidation and lipoxidation in the cardiovascular system of Fischer 344 rats

2004 • 32 citations

Age-dependent increase of indigenous dna adducts in rat brain is associated with a lipid peroxidation product

1996 • 31 citations

Non-enzymatic lipid peroxidation of microsomes and mitochondria isolated from liver and heart of pigeon and rat

2000 • 30 citations

Protein modification by advanced Maillard adducts can be modulated by dietary polyunsaturated fatty acids

2003 • 26 citations

Aging Rate, Mitochondrial Free Radical Production, and Constitutive Sensitivity to Lipid Peroxidation: Insights From Comparative Studies

2003 • 22 citations

Δ6-desaturase: improved methodology and analysis of the kinetics in a multi-enzyme system

1996 • 20 citations

Modulation of age-related alterations of iron, ferritin, and lipid peroxidation in rat brain synaptosomes.

1998 • 11 citations

Lesión oxidativa de proteínas de hígado y corazón de rata durante el proceso de envejecimiento

2006 • 5 citations

Mutant Genes That Extend Life Span

1987 • 4 citations