Cross-presentation: a general mechanism for CTL immunity and tolerance

The Dendritic Cell System and its Role in Immunogenicity

1991 • 4,733 citations

Tolerance, Danger, and the Extended Family

1994 • 4,654 citations

Lymphocyte Homing and Homeostasis

1996 • 2,934 citations

T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

1998 • 2,615 citations

Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products.

1995 • 2,531 citations

Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs

1998 • 2,378 citations

A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell

1998 • 2,373 citations

Help for cytotoxic-T-cell responses is mediated by CD40 signalling

1998 • 2,106 citations

Antigen-specific interaction between T and B cells

1985 • 1,396 citations

Ablation of “tolerance” and induction of diabetes by virus infection in viral antigen transgenic mice

1991 • 1,187 citations

Inflammatory stimuli induce accumulation of MHC class II complexes on dendritic cells

1997 • 1,143 citations

Introduction of soluble protein into the class I pathway of antigen processing and presentation

1988 • 1,105 citations

The Biochemistry and Cell Biology of Antigen Processing and Presentation

1993 • 1,022 citations

Cross-priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross-react in the cytotoxic assay.

1976 • 951 citations

Maturation Stages of Mouse Dendritic Cells in Growth Factor–dependent Long-Term Cultures

1997 • 860 citations

A Mechanism for the Specific Immunogenicity of Heat Shock Protein-Chaperoned Peptides

1995 • 838 citations

Cloned dendritic cells can present exogenous antigens on both MHC class I and class II molecules.

1997 • 837 citations

Viral Strategies of Immune Evasion

1998 • 791 citations

Virus infection triggers insulin-dependent diabetes mellitus in a transgenic model: Role of anti-self (virus) immune response

1991 • 766 citations

Developmental regulation of MHC class II transport in mouse dendritic cells

1997 • 754 citations

Induction of a CD8+ Cytotoxic T Lymphocyte Response by Cross-priming Requires Cognate CD4+ T Cell Help

1997 • 729 citations

Class I–restricted Cross-Presentation of Exogenous Self-Antigens Leads to Deletion of Autoreactive CD8+ T Cells

1997 • 719 citations

Constitutive class I-restricted exogenous presentation of self antigens in vivo.

1996 • 637 citations

Phagocytic processing of bacterial antigens for class I MHC presentation to T cells

1993 • 625 citations

ANTIGEN PROCESSING AND PRESENTATION BY THE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX

1996 • 613 citations

Efficient major histocompatibility complex class I presentation of exogenous antigen upon phagocytosis by macrophages.

1993 • 592 citations

Heat shock proteins transfer peptides during antigen processing and CTL priming

1994 • 580 citations

Progressive loss of CD8+ T cell-mediated control of a gamma-herpesvirus in the absence of CD4+ T cells.

1996 • 515 citations

Helper activity is required for the in vivo generation of cytotoxic T lymphocytes

1982 • 511 citations

Gene vaccination with naked plasmid DNA: mechanism of CTL priming.

1996 • 494 citations

Activated T cells induce interleukin‐12 production by monocytes via CD40‐CD40 ligand interaction

1995 • 427 citations

CD40 Ligand-Dependent T Cell Activation: Requirement of B7-CD28 Signaling Through CD40

1996 • 421 citations

Class I MHC presentation of exogenous soluble antigen via macropinocytosis in bone marrow macrophages

1995 • 416 citations

Class I-restricted processing and presentation of exogenous cell-associated antigen in vivo.

1990 • 414 citations

Phagocytic processing of exogenous particulate antigens by macrophages for presentation by class I MHC molecules.

1994 • 383 citations

Constitutive macropinocytosis allows TAP‐dependent major histocompatibility compex class I presentation of exogenous soluble antigen by bone marrow‐derived dendritic cells

1997 • 351 citations

Cross-priming of minor histocompatibility antigen-specific cytotoxic T cells upon immunization with the heat shock protein gp96.

1995 • 339 citations

CD4+ T Cell Help Impairs CD8+ T Cell Deletion Induced by Cross-presentation of Self-Antigens and Favors Autoimmunity

1997 • 320 citations

CD28-B7 interactions in T-cell activation

1994 • 315 citations

CD28-B7 interactions allow the induction of CD8+ cytotoxic T lymphocytes in the absence of exogenous help.

1993 • 274 citations

T-cell memory: the connection between function, phenotype and migration pathways

1991 • 271 citations

In Vivo Cross-Priming of MHC Class I–Restricted Antigens Requires the TAP Transporter

1996 • 225 citations

Cells Process Exogenous Proteins for Recognition by Cytotoxic T Lymphocytes

1988 • 217 citations

Peripheral tolerance to an islet cell‐specific hemagglutinin transgene affects both CD4⁺ and CD8⁺ T cells

1992 • 217 citations

Class discrimination in the world of immunology

1987 • 214 citations

Characterization of antigen-presenting cells that present exogenous antigens in association with class I MHC molecules.

1993 • 206 citations

Presentation of Exogenous Protein Antigens on Major Histocompatability Complex Class I Molecules by Dendritic Cells: Pathway of Presentation and Regulation by Cytokines

1997 • 195 citations

M-CSF-induced macropinocytosis increases solute endocytosis but not receptor-mediated endocytosis in mouse macrophages

1992 • 188 citations

Macrophages as accessory cells for class I MHC-restricted immune responses.

1991 • 148 citations

Hepatitis B virus small surface antigen particles are processed in a novel endosomal pathway for major histocompatibility complex class I‐restricted epitope presentation

1995 • 146 citations

Three‐cell‐type clusters of T cells with antigen‐presenting cells best explain the epitope linkage and noncognate requirements of the in vivo cytolytic response

1987 • 141 citations

Minor but not major histocompatibility antigens of thymus epithelium tolerize precursors of cytolytic T cells

1986 • 109 citations

TAP1‐independent loading of class I molecules by exogenous viral proteins

1995 • 101 citations

Induction of protective cytotoxic T cells with viral proteins

1994 • 91 citations

CD4⁺8⁻ help prevents rapid deletion of CD8⁺ cells after a transient response to antigen

1993 • 88 citations

Cooperation between Helper T Cells and Cytotoxic T Lymphocyte Precursors

1988 • 86 citations

The effect of allogeneic presensitization on H-Y graft survival and in vitro cell-mediated responses to H-y antigen.

1976 • 82 citations

Priming of cytotoxic T lymphocytes by five heat‐aggregated antigens in vivo: Conditions, efficiency, and relation to antibody responses

1997 • 75 citations

Immune Response to Human Papillomaviruses and the Prospects for Human Papillomavirus-Specific Immunisation

1994 • 72 citations

Linked Recognition of Helper and Cytotoxic Antigenic Determinants for the Generation of Cytotoxic T Lymphocytes^a

1988 • 67 citations

A conditionally immortalized dendritic cell line which differentiates in contact with T cells or T cell‐derived cytokines

1996 • 29 citations

Helper effects required during in vivo priming for a cytolytic response to the H-Y antigen in nonresponder mice.

1985 • 22 citations

Deleted Work

1955 • 0 citations