Hyper IgM syndrome associated with defective CD40-mediated B cell activation.

Mechanism of antigen-driven selection in germinal centres

1989 • 1,097 citations

Molecular and biological characterization of a murine ligand for CD40

1992 • 1,029 citations

The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome

1993 • 840 citations

CD40 Ligand Gene Defects Responsible for X-Linked Hyper-IgM Syndrome

1993 • 836 citations

Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM

1993 • 739 citations

CD40 ligand mutations in X-linked immunodeficiency with hyper-IgM

1993 • 719 citations

Long-Term Human B Cell Lines Dependent on Interleukin-4 and antibody to CD40

1991 • 554 citations

A B-lymphocyte activation molecule related to the nerve growth factor receptor and induced by cytokines in carcinomas.

1989 • 527 citations

The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity.

1992 • 518 citations

The rate of spontaneous mutation of a human gene

1935 • 510 citations

Activation of human B cells mediated through two distinct cell surface differentiation antigens, Bp35 and Bp50.

1986 • 439 citations

Activated human T cells express a ligand for the human B cell‐associated antigen CD40 which participates in T cell‐dependent activation of B lymphocytes

1992 • 323 citations

Immunodeficiency with hyper-IgM (HIM).

1992 • 318 citations

CD40 preferentially costimulates activation of CD4+ T lymphocytes.

1994 • 255 citations

CD40 ligand expression is defective in a subset of patients with common variable immunodeficiency.

1994 • 236 citations

Anti-CD45 inhibition of human B cell proliferation depends on the nature of activation signals and the state of B cell activation. A study with anti-IgM and anti-CDw40 antibodies.

1989 • 91 citations

Identification of a source of biologically active CD40 ligand

1992 • 81 citations

Activated B cells from patients with common variable immunodeficiency proliferate and synthesize immunoglobulin.

1993 • 74 citations

Deletions in the ligand for CD40 in X-linked immunoglobulin deficiency with normal or elevated IgM (HIGMX-1)

1993 • 67 citations

B cells from CBA/N mice do not proliferate following ligation of CD40

1994 • 55 citations

Immunologic studies of three family members with the immunodeficiency with hyper-IgM syndrome

1983 • 32 citations

DYSGAMMAGLOBULINEMIA: REPORT OF A CASE WITH A FAMILY HISTORY OF A CONGENITAL GAMMA GLOBULIN DISORDER

1964 • 30 citations

A cell culture system that enhances mononuclear cell IgE synthesis induced by recombinant human interleukin-4

1990 • 28 citations

Genomic organization and chromosomal localization of the human CD27 gene.

1992 • 25 citations

CD40 LIGAND GENE DEFECTS RESPONSIBLE FOR X-LINKED HYPER-IgM SYNDROME

1994 • 14 citations

Immunodeficiency with hyper IgM after systemic lupus erythematosus

1984 • 12 citations

THE CD40 LIGAND gp39, IS DEFECTIVE IN ACTIVATED T CELLS FROM PATIENTS WITH X-LINKED HYPER-IgM SYNDROME

1994 • 12 citations

DEFECTIVE EXPRESSION OF T-CELL CD40 LIGAND CAUSES X-LINKED IMMUNODEFICIENCY WITH HYPER IgM

1994 • 11 citations

CD40 LIGAND MUTATIONS IN X-LINKED IMMUNODEFICIENCY WITH HYPER-IgM

1994 • 10 citations

IgM cryoprecipitation and anti-immunoglobulin activity in dysgammaglobulinemia type I

1982 • 7 citations