An alternative approach to deoxyoligonucleotides as hybridization probes by insertion of deoxyinosine at ambiguous codon positions.

Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ

1977 • 4,696 citations

Construction and characterization of new cloning vehicles. II. A multipurpose cloning system. 1977.

1992 • 4,683 citations

A complementation analysis of the restriction and modification of DNA in Escherichia coli

1969 • 3,866 citations

Construction and characterization of new cloning vehicle. II. A multipurpose cloning system

1977 • 3,829 citations

Codon—anticodon pairing: The wobble hypothesis

1966 • 1,961 citations

The isolation and characterization of linked δ- and β-globin genes from a cloned library of human DNA

1978 • 1,055 citations

Phosphorylation of nucleic acid by an enzyme from T4 bacteriophage-infected Escherichia coli.

1965 • 609 citations

Physicochemical studies on polydeoxyribonucleotides containing defined repeating nucleotide sequences

1970 • 550 citations

Chromatography of ³²P‐Labelled Oligonucleotides on Thin Layers of DEAE‐Cellulose

1969 • 511 citations

The use of synthetic oligonucleotides as hybridization probes. II. Hybridization of oligonucleotides of mixed sequence to rabbit β-globin DNA

1981 • 473 citations

Use of synthetic oligonucleotides as hybridization probes: isolation of cloned cDNA sequences for human beta 2-microglobulin.

1981 • 423 citations

Studies on Polynucleotides. XXIV.¹ The Stepwise Synthesis of Specific Deoxyribopolynucleotides (4).² Protected Derivatives of Deoxyribonucleosides and New Syntheses of Deoxyribonucleoside-3″ Phosphates³

1963 • 397 citations

[21] Transformation and preservation of competent bacterial cells by freezing

1979 • 278 citations

The use of nuclease P₁in sequence analysis of end group labeled RNA

1977 • 240 citations

Solid phase synthesis of polynucleotides. VI. Farther studies on polystyrene copolymers for the solid support

1982 • 219 citations

Oligonucleotide-directed mutagenesis as a general and powerful method for studies of protein function.

1982 • 211 citations

Physical and chemical characterization of the ordered complexes formed between polyinosinic acid, polycytidylic acid and their deoxyribo-analogues

1965 • 173 citations

An infrared study of the hydrogen-bonding specificity of hypoxanthine and other nucleic acid derivatives

1969 • 150 citations

Identification and isolation of the yeast cytochrome c gene

1978 • 119 citations

Construction and selection of recombinant plasmids containing full-length complementary DNAs corresponding to rat insulins I and II.

1979 • 110 citations

THE FORMATION OF A HELICAL COMPLEX BETWEEN POLYINOSINIC ACID AND POLYCYTIDYLIC ACID

1958 • 97 citations

Formation of two- and three-Stranded Helical Molecules by Polyinosinic Acid and Polyadenylic Acid

1958 • 94 citations

Synthesis of a gene for human growth hormone and its expression in Escherichia coli.

1984 • 93 citations

Simplifications in the synthesis of short oligonucleotide blocks

1980 • 71 citations

Polyinosinic Plus Polycytidylic Acid: A Crystalline Polynucleotide Complex

1960 • 54 citations

Molecular cloning of human gastrin precursor cDNA

1983 • 47 citations

Studies on deoxyribonucleic acids and related compounds. V. Synthesis of pentadecanucleotide duplex containing the ideal Pribnow sequence of promoter by the phosphotriester method using a new phosphorylating reagent

1982 • 16 citations