Site of injury‐directed induction of heme oxygenase‐1 and ‐2 in experimental spinal cord injury: differential functions in neuronal defense mechanisms?

NITRIC OXIDE AND MACROPHAGE FUNCTION

1997 • 4,106 citations

A Randomized, Controlled Trial of Methylprednisolone or Naloxone in the Treatment of Acute Spinal-Cord Injury

1990 • 2,629 citations

THE HEME OXYGENASE SYSTEM:A Regulator of Second Messenger Gases

1997 • 2,481 citations

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

1995 • 2,436 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

Identification of a Neural Stem Cell in the Adult Mammalian Central Nervous System

1999 • 1,872 citations

The Receptor for the Cytotoxic Ligand TRAIL

1997 • 1,755 citations

Carbon Monoxide: a Putative Neural Messenger

1993 • 1,519 citations

Iron accumulation in Alzheimer disease is a source of redox-generated free radicals

1997 • 1,304 citations

Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys

1997 • 1,147 citations

Nucleocytoplasmic Transport

1996 • 1,071 citations

Gases as biological messengers: nitric oxide and carbon monoxide in the brain

1994 • 1,052 citations

Neuronal and Glial Apoptosis after Traumatic Spinal Cord Injury

1997 • 901 citations

Isolation and Characterization of a cDNA from the Rat Brain that Encodes Hemoprotein Heme Oxygenase‐3

1997 • 834 citations

Heme oxygenase: A novel target for the modulation of inflammatory response

1996 • 784 citations

Antioxidant activity of albumin-bound bilirubin.

1987 • 763 citations

Characterization of two constitutive forms of rat liver microsomal heme oxygenase. Only one molecular species of the enzyme is inducible.

1986 • 748 citations

Nitric Oxide And Carbon Monoxide Produce Activity-Dependent Long-Term Synaptic Enhancement in Hippocampus

1993 • 562 citations

Gene expression and the thiol redox state

1999 • 511 citations

Acute Inflammatory Response in Spinal Cord Following Impact Injury

1998 • 486 citations

MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia

1999 • 468 citations

Cloning and expression of cDNA for rat heme oxygenase.

1985 • 451 citations

CD95 Ligand (Fas-L/APO-1L) and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Mediate Ischemia-Induced Apoptosis in Neurons

1999 • 435 citations

Traumatic spinal cord injury induces nuclear factor-kappaB activation.

1998 • 434 citations

Overexpression of Heme Oxygenase‐1 Is Neuroprotective in a Model of Permanent Middle Cerebral Artery Occlusion in Transgenic Mice

1999 • 418 citations

Traumatic Spinal Cord Injury Induces Nuclear Factor-κB Activation

1998 • 379 citations

Amyotrophic lateral sclerosis: Part 1. Clinical features, pathology, and ethical issues in management

1985 • 369 citations

p53-dependent and -independent regulation of the death receptor KILLER/DR5 gene expression in response to genotoxic stress and tumor necrosis factor alpha.

1998 • 363 citations

Cyclic Nucleotide-Gated Ion Channels: An Extended Family With Diverse Functions

1996 • 305 citations

Thiol Compounds Interact with Nitric Oxide in Regulating Heme Oxygenase-1 Induction in Endothelial Cells

1997 • 297 citations

Heme oxygenase-1 inhibits TNF-α-induced apoptosis in cultured fibroblasts

2000 • 296 citations

Activation of NF-κB by FADD, Casper, and Caspase-8

2000 • 291 citations

Evidence suggesting that the two forms of heme oxygenase are products of different genes.

1988 • 288 citations

p53 and apoptosis

1998 • 282 citations

Alteration in extracellular amino acids after traumatic spinal cord injury

1990 • 280 citations

Rapid induction of heme oxygenase 1 mRNA and protein by hyperthermia in rat brain: heme oxygenase 2 is not a heat shock protein.

1991 • 267 citations

Reversal of long-term potentiation by inhibitors of haem oxygenase

1993 • 265 citations

Heme Oxygenase: Clinical Applications and Functions

1992 • 264 citations

Pathophysiology of spinal cord trauma

1993 • 261 citations

Apoptosis and Expression of Bcl-2 after Compression Trauma to Rat Spinal Cord

1996 • 259 citations

Nitric oxide and carbon monoxide: parallel roles as neural messengers

1998 • 232 citations

Carbon monoxide and nitric oxide as coneurotransmitters in the enteric nervous system: Evidence from genomic deletion of biosynthetic enzymes

2000 • 199 citations

P53- and CD95-associated apoptosis in neurodegenerative diseases.

1998 • 196 citations

Normal and Heat‐Induced Patterns of Expression of Heme Oxygenase‐1 (HSP32) in Rat Brain: Hyperthermia Causes Rapid Induction of mRNA and Protein

1992 • 195 citations

Adaptive responses and apoptosis in endothelial cells exposed to carbon monoxide

2000 • 192 citations

In situ hybridization and immunohistochemical localization of heme oxygenase-2 mRNA and protein in normal rat brain: Differential distribution of isozyme 1 and 2

1992 • 191 citations

Heme Oxygenase-2 Is a Hemoprotein and Binds Heme through Heme Regulatory Motifs That Are Not Involved in Heme Catalysis

1997 • 182 citations

Glutathione Depletion Induces Heme Oxygenase‐1 (HSP32) mRNA and Protein in Rat Brain

1993 • 180 citations

Regulation of heme oxygenase-1 gene expression in vascular smooth muscle cells by nitric oxide

1997 • 175 citations

The cellular Na+ pump as a site of action for carbon monoxide and glutamate: A mechanism for long-term modulation of cellular activity

1995 • 170 citations

Signalling by cGMP-dependent protein kinases

1996 • 169 citations

Developmental expression of heme oxygenase isozymes in rat brain. Two HO-2 mRNAs are detected.

1990 • 166 citations

Fas/Apo [apoptosis]-1 and associated proteins in the differentiating cerebral cortex: induction of caspase-dependent cell death and activation of NF-kappaB.

1999 • 157 citations

Corticosterone Regulates Heme Oxygenase‐2 and NO Synthase Transcription and Protein Expression In Rat Brain

1994 • 148 citations

Heme Oxygenase-1 is Induced in Glia Throughout Brain by Subarachnoid Hemoglobin

1998 • 148 citations

Isolation, characterization, and expression in Escherichia coli of a cDNA encoding rat heme oxygenase-2.

1990 • 147 citations

Regulation of Gene Expression by Cyclic GMP-Dependent Protein Kinase Requires Nuclear Translocation of the Kinase: Identification of a Nuclear Localization Signal

1997 • 121 citations

Fas/Apo [Apoptosis]-1 and Associated Proteins in the Differentiating Cerebral Cortex: Induction of Caspase-Dependent Cell Death and Activation of NF-κB

1999 • 120 citations

Permanent focal and transient global cerebral ischemia increase glial and neuronal expression of heme oxygenase-1, but not heme oxygenase-2, protein in rat brain

1996 • 120 citations

Sequential expression of c-fos protooncogene, TNF-alpha, and dynorphin genes in spinal cord following experimental traumatic injury

1994 • 120 citations

The structure, organization and differential expression of the gene encoding rat heme oxygenase-2

1994 • 117 citations

Stress protein-induced immunosuppression: inhibition of cellular immune effector functions following overexpression of haem oxygenase (HSP 32)

1998 • 114 citations

Nitric oxide-mediated cGMP synthesis in oligodendrocytes in the developing rat brain

1997 • 109 citations

Interaction of heme oxygenase‐2 with nitric oxide donors

1999 • 109 citations

Cytokines and the hypothalamic-pituitary-adrenal axis

1990 • 107 citations

Apoptosis following spinal cord injury in rats and preventative effect of N-methyl-d-aspartate receptor antagonist

1999 • 106 citations

Nitric oxide induces heme oxygenase-1 via mitogen-activated protein kinases ERK and p38.

2000 • 105 citations

Rat liver cytochrome P-450b, P-420b, and P-420c are degraded to biliverdin by heme oxygenase

1988 • 95 citations

Hypoxia-Ischemia, but Not Hypoxia Alone, Induces the Expression of Heme Oxygenase-1 (HSP32) in Newborn Rat Brain

1997 • 87 citations

Chemokine antagonist infusion attenuates cellular infiltration following spinal cord contusion injury in rat

2000 • 84 citations

Sources of carbon monoxide (CO) in biological systems and applications of CO detection technologies.

1994 • 83 citations

Histochemical localization of heme oxygenase-2 protein and mRNA expression in rat brain

1997 • 82 citations

Clip Compression Injury in the Spinal Cord: A Correlative Study of Neurological and Morphological Alterations

1997 • 77 citations

Glucocorticoid Receptor Expression in the Spinal Cord after Traumatic Injury in Adult Rats

1999 • 77 citations

Spin trap (N-t-butyl-alpha-phenylnitrone)-mediated suprainduction of heme oxygenase-1 in kidney ischemia/reperfusion model: role of the oxygenase in protection against oxidative injury.

1999 • 58 citations

Characterization and Biological Significance of Immunosuppressive Peptide D2702.75–84(E → V) Binding Protein

1998 • 58 citations

Induction of heme oxygenase-1 (HO-1) in the contused spinal cord of the rat

1998 • 55 citations

Generation and Detection of Hydroxyl Radical Following Experimental Head Injury

1994 • 54 citations

Heme Oxygenase, a Likely Regulator of cGMP Production in the Brain: Induction in Vivo of HO-1 Compensates for Depression in NO Synthase Activity

1993 • 54 citations

Developmentally regulated expression of two transcripts for heme oxygenase-2 with a first exon unique to rat testis: control by corticosterone of the oxygenase protein expression

2000 • 53 citations

Ferritin as a source of iron and protection from iron-induced toxicities

1995 • 52 citations

Role of N-methyl-d-aspartate receptor in acute spinal cord injury

1995 • 48 citations

NMDA receptor blockade rescues Clarke's and red nucleus neurons after spinal hemisection

1994 • 41 citations

Enhanced neuronal expression of the oxidoreductase — biliverdin reductase — after permanent focal cerebral ischemia

1999 • 39 citations

Glucocorticoid Therapy of Spinal Cord Injury^a

1994 • 39 citations

Ischemic Neurons in Rat Brains After 6, 8, or 10 Minutes of Transient Hypoxic Ischemia

1997 • 39 citations

Neuronal Overexpression of Heme Oxygenase‐1 Correlates with an Attenuated Exploratory Behavior and Causes an Increase in Neuronal NADPH Diaphorase Staining

1998 • 38 citations

Differential localization of heme oxygenase and NADPH-diaphorase in spinal cord neurons

1995 • 37 citations

Peripheral Nerve Graft and Neurotrophic Factors Enhance Neuronal Survival and Expression of Nitric Oxide Synthase in Clarke's Nucleus after Hemisection of the Spinal Cord in Adult Rat

1999 • 32 citations

Three-dimensional topographic analysis of spinal accessory motoneurons under chronic mechanical compression: an experimental study in the mouse

1997 • 32 citations

Localization and age-related changes of nitric oxide- and ANP-mediated cyclic-GMP synthesis in rat cervical spinal cord: an immunocytochemical study

2000 • 30 citations

cGMP-inhibited phosphodiesterases (PDE3 gene family)

1996 • 30 citations

Corticosterone Has a Permissive Effect on Expression of Heme Oxygenase‐1 in CA1–CA3 Neurons of Hippocampus in Thermal‐Stressed Rats

1995 • 28 citations

Chronic morphine exposure and the expression of heme oxygenase type 2

2000 • 23 citations

Induction of apoptosis, p53 and heme oxygenase-1 by cytotoxic prostaglandin Δ12-PGJ2 in transformed endothelial cells

1998 • 22 citations

Expression of heme oxygenase-1 mediated by non-NMDA and metabotropic receptors in glial cells: possible involvement of reactive oxygen species production and protein kinase C activation

1999 • 18 citations

Nitric oxide‐mediated cGMP synthesis in oligodendrocytes in the developing rat brain

1997 • 6 citations