CTLA-4 Is Important in Maintaining Long-Term Survival of Cardiac Allografts

Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation

2000 • 2,211 citations

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

1992 • 1,573 citations

The Role of the CD28 Receptor During T Cell Responses to Antigen

1993 • 1,320 citations

Complexities of CD28/B7: CTLA-4 Costimulatory Pathways in Autoimmunity and Transplantation

2001 • 1,032 citations

Induction of Peripheral T Cell Tolerance In Vivo Requires CTLA-4 Engagement

1997 • 736 citations

Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells

2003 • 674 citations

Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes.

1992 • 592 citations

Regulation of T Cell Receptor Signaling by Tyrosine Phosphatase SYP Association with CTLA-4

1996 • 529 citations

T-Cell Proliferation Involving the CD28 Pathway Is Associated witH Cyclosporine-Resistant Interleukin 2 Gene Expression

1987 • 522 citations

T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression.

1987 • 354 citations

Structural basis for co-stimulation by the human CTLA-4/B7-2 complex

2001 • 333 citations

Modulation of TCR-induced transcriptional profiles by ligation of CD28, ICOS, and CTLA-4 receptors

2002 • 300 citations

Cutting Edge: A Soluble Form of CTLA-4 in Patients with Autoimmune Thyroid Disease

2000 • 227 citations

Efficient expansion of regulatory T cells in vitro and in vivo with a CD28 superagonist

2003 • 186 citations

Tracking the Immunoregulatory Mechanisms Active During Allograft Tolerance

2002 • 180 citations

CTLA4 Signals Are Required to Optimally Induce Allograft Tolerance with Combined Donor-Specific Transfusion and Anti-CD154 Monoclonal Antibody Treatment

1999 • 177 citations

CD28 is an inducible T cell surface antigen that transduces a proliferative signal in CD3+ mature thymocytes.

1990 • 173 citations

CTLA-4 Suppresses Proximal TCR Signaling in Resting Human CD4+ T Cells by Inhibiting ZAP-70 Tyr319 Phosphorylation: A Potential Role for Tyrosine Phosphatases

2002 • 118 citations

The balance of deletion and regulation in allograft tolerance

2003 • 108 citations

The in vivo mechanism of action of CTLA4Ig.

1996 • 106 citations

Regulatory functions of self-restricted MHC class II allopeptide-specific Th2 clones in vivo

2001 • 100 citations

The Role of the CD134-CD134 Ligand Costimulatory Pathway in Alloimmune Responses In Vivo

2003 • 91 citations

Physiological Mechanisms of Regulating Alloimmunity: Cytokines, CTLA-4, CD25+ Cells, and the Alloreactive T Cell Clone Size

2002 • 78 citations

PROLONGED ALLOGRAFT SURVIVAL BUT NO TOLERANCE INDUCTION BY MODULATING CD28 ANTIBODY JJ319 AFTER HIGH-RESPONDER RAT HEART TRANSPLANTATION1

1999 • 62 citations

T-CELL COSTIMULATORY BLOCKADE IN EXPERIMENTAL CHRONIC CARDIAC ALLOGRAFT REJECTION

1997 • 59 citations

The anti-T cell monoclonal antibody 9.3 (Anti-CD28) provides a helper signal and bypasses the need for accessory cells in T Cell activation with immobilized anti-CD3 and mitogens

1989 • 42 citations

Mechanisms of targeting cd28 by a signaling monoclonal antibody in acute and chronic allograft rejection1

2002 • 38 citations

CD152 Ligation by CD80 on T Cells Is Required for the Induction of Unresponsiveness by Costimulation-Deficient Antigen Presentation

2000 • 34 citations

Interaction Between ICOS-B7RP1 and B7-CD28 Costimulatory Pathways in Alloimmune Responses In Vivo

2003 • 32 citations

A novel CD154 monoclonal antibody in acute and chronic rat vascularized cardiac allograft rejection1

2002 • 25 citations

Viewpoint: Therapeutic Implications of CTLA-4 Compartmentalization

2003 • 11 citations

A MAb against Rat CTLA-4 (CD152)

2003 • 1 citations