Cardiolipin metabolism and Barth Syndrome

Gene Action in the X-chromosome of the Mouse (Mus musculus L.)

1961 • 3,881 citations

The proteome of Saccharomyces cerevisiae mitochondria

2003 • 890 citations

The biosynthesis and functional role of cardiolipin

2000 • 786 citations

A novel X-linked gene, G4.5. is responsible for Barth syndrome

1996 • 733 citations

An X-linked mitochondrial disease affecting cardiac muscle, skeletal muscle and neutrophil leucocytes

1983 • 662 citations

Gluing the Respiratory Chain Together

2002 • 615 citations

Cardiolipins and biomembrane function

1992 • 597 citations

A unique mitochondria-associated membrane fraction from rat liver has a high capacity for lipid synthesis and contains pre-Golgi secretory proteins including nascent lipoproteins.

1994 • 431 citations

Absence of Cardiolipin in the crd1 Null Mutant Results in Decreased Mitochondrial Membrane Potential and Reduced Mitochondrial Function

2000 • 409 citations

Defective Remodeling of Cardiolipin and Phosphatidylglycerol in Barth Syndrome

2000 • 369 citations

Cardiolipin Is Essential for Organization of Complexes III and IV into a Supercomplex in Intact Yeast Mitochondria

2005 • 321 citations

ADP/ATP carrier protein from beef heart mitochondria has high amounts of tightly bound cardiolipin, as revealed by phosphorus-31 nuclear magnetic resonance

1985 • 296 citations

ROLE of MITOCHONDRIA in TOXIC OXIDATIVE STRESS

2005 • 283 citations

X‐linked cardioskeletal myopathy and neutropenia (Barth syndrome): An update

2004 • 273 citations

X-linked dilated cardiomyopathy with neutropenia, growth retardation, and 3-methylglutaconic aciduria

1991 • 270 citations

Deficiency of tetralinoleoyl‐cardiolipin in Barth syndrome

2002 • 264 citations

Cardiolipin and apoptosis

2002 • 260 citations

The Cytochrome bc 1 and Cytochromec Oxidase Complexes Associate to Form a Single Supracomplex in Yeast Mitochondria

2000 • 252 citations

The X-Linked Gene G4.5 Is Responsible for Different Infantile Dilated Cardiomyopathies

1997 • 229 citations

A Novel Cardiolipin-remodeling Pathway Revealed by a Gene Encoding an Endoplasmic Reticulum-associated Acyl-CoA:Lysocardiolipin Acyltransferase (ALCAT1) in Mouse

2004 • 214 citations

The reconstituted ADP/ATP carrier activity has an absolute requirement for cardiolipin as shown in cysteine mutants.

1994 • 210 citations

Taz1, an Outer Mitochondrial Membrane Protein, Affects Stability and Assembly of Inner Membrane Protein Complexes: Implications for Barth Syndrome

2005 • 206 citations

Remodeling of Cardiolipin by Phospholipid Transacylation

2003 • 203 citations

Phospholipid abnormalities in children with Barth syndrome

2003 • 195 citations

Aberrant cardiolipin metabolism in the yeast taz1 mutant: a model for Barth syndrome

2003 • 192 citations

Cardiolipin is not essential for the growth of Saccharomyces cerevisiae on fermentable or non‐fermentable carbon sources

1997 • 182 citations

Lack of Mitochondrial Anionic Phospholipids Causes an Inhibition of Translation of Protein Components of the Electron Transport Chain

2001 • 178 citations

X‐linked cardioskeletal myopathy and neutropenia (Barth syndrome) (MIM 302060)

1999 • 168 citations

Cardiolipin is synthesized on the matrix side of the inner membrane in rat liver mitochondria.

1993 • 161 citations

An X-Linked Recessive Cardiomyopathy with Abnormal Mitochondria

1979 • 150 citations

Cardiolipin Biosynthesis and Mitochondrial Respiratory Chain Function Are Interdependent

2004 • 146 citations

Mapping of the locus for X-linked cardioskeletal myopathy with neutropenia and abnormal mitochondria (Barth syndrome) to Xq28.

1991 • 144 citations

Cell membranes and apoptosis: role of cardiolipin, phosphatidylcholine, and anticancer lipid analogues

2004 • 143 citations

Cardiolipin prevents rate-dependent uncoupling and provides osmotic stability in yeast mitochondria

2002 • 139 citations

Monolysocardiolipins accumulate in Barth syndrome but do not lead to enhanced apoptosis

2005 • 138 citations

Synthetic Lethal Interaction of the Mitochondrial Phosphatidylethanolamine and Cardiolipin Biosynthetic Pathways in Saccharomyces cerevisiae

2005 • 134 citations

Mutation Characterization and Genotype-Phenotype Correlation in Barth Syndrome

1997 • 134 citations

Only One Splice Variant of the Human TAZ Gene Encodes a Functional Protein with a Role in Cardiolipin Metabolism

2003 • 132 citations

Oxidative phosphorylation in cardiolipin-lacking yeast mitochondria

2000 • 126 citations

Cloning and characterization of murine 1-acyl-sn-glycerol 3-phosphate acyltransferases and their regulation by PPARα in murine heart

2005 • 123 citations

Cell biology of cardiac mitochondrial phospholipids

2004 • 118 citations

Lysocardiolipin formation and reacylation in isolated rat liver mitochondria

1990 • 118 citations

Barth syndrome: Clinical features and confirmation of gene localisation to distal Xq28

1993 • 117 citations

Quantitative and Compositional Study of Cardiolipin in Platelets by Electrospray Ionization Mass Spectrometry: Application for the Identification of Barth Syndrome Patients

2002 • 114 citations

Mitochondrial dysfunction of a cultured Chinese hamster ovary cell mutant deficient in cardiolipin.

1993 • 113 citations

The mechanism of cardiolipin biosynthesis in liver mitochondria

1972 • 105 citations

Neutrophils in Barth syndrome (BTHS) avidly bind annexin-V in the absence of apoptosis

2004 • 104 citations

The Human TAZ Gene Complements Mitochondrial Dysfunction in the Yeast taz1Δ Mutant

2004 • 104 citations

Absence of Cardiolipin Results in Temperature Sensitivity, Respiratory Defects, and Mitochondrial DNA Instability Independent of pet56

2004 • 101 citations

Barth syndrome: Clinical observations and genetic linkage studies

1994 • 100 citations

Cardiolipin deficiency in x-linked cardioskeletal myopathy and neutropenia (barth syndrome, mim 302060): a study in cultured skin fibroblasts

2002 • 100 citations

Isolation of a Chinese Hamster Ovary (CHO) cDNA Encoding Phosphatidylglycerophosphate (PGP) Synthase, Expression of Which Corrects the Mitochondrial Abnormalities of a PGP Synthase-defective Mutant of CHO-K1 Cells

1999 • 97 citations

Regulation of Cardiolipin Biosynthesis in H9c2 Cardiac Myoblasts by Cytidine 5′-Triphosphate

1996 • 88 citations

Further studies on the formation of cardiolipin and phosphatidylglycerol in rat liver mitochondria

1975 • 87 citations

Acylation of monolysocardiolipin in rat heart

1999 • 80 citations

Ypr140wp, ‘the yeast tafazzin’, displays a mitochondrial lysophosphatidylcholine (lyso-PC) acyltransferase activity related to triacylglycerol and mitochondrial lipid synthesis

2005 • 78 citations

Linoleic acid supplemention of Barth syndrome fibroblasts restores cardiolipin levels: implications for treatment

2003 • 76 citations

Purification and Characterization of Monolysocardiolipin Acyltransferase from Pig Liver Mitochondria

2003 • 75 citations

Cardiolipin Is Not Required for Bax-mediated Cytochrome c Release from Yeast Mitochondria

2004 • 74 citations

X Chromosome Inactivation in Carriers of Barth Syndrome

1998 • 74 citations

Microanalysis of cardiolipin in small biopsies including skeletal muscle from patients with mitochondrial disease

1999 • 70 citations

Molecular species of cardiolipin in relation to other mitochondrial phospholipids

1991 • 69 citations

Barth syndrome: TAZ gene mutations, mRNAs, and evolution

2005 • 65 citations

Mitochondria in apoptosis: past, present and future

2004 • 63 citations

Cardiolipin synthase expression is essential for growth at elevated temperature and is regulated by factors affecting mitochondrial development

1999 • 62 citations

Phenotypic heterogeneity in the syndromes of 3-methylglutaconic aciduria

1991 • 61 citations

X linked fatal infantile cardiomyopathy maps to Xq28 and is possibly allelic to Barth syndrome.

1995 • 58 citations

Defects of the mitochondrial respiratory chain complexes in three pediatric cases with hypotonia and cardiac involvement

1992 • 57 citations

Species pattern of phosphatidic acid, diacylglycerol, CDP-diacylglycerol and phosphatidylglycerol synthesized de novo in rat liver mitochondria

1989 • 45 citations

Dilated cardiomyopathy with neutropenia, short stature, and abnormal carnitine metabolism

1988 • 44 citations

Regulation of phosphatidylglycerolphosphate synthase in Saccharomyces cerevisiae by factors affecting mitochondrial development

1991 • 42 citations

Cardiolipin Is Not Required to Maintain Mitochondrial DNA Stability or Cell Viability for Saccharomyces cerevisiae Grown at Elevated Temperatures

2003 • 37 citations

Oxidative phosphorylation in cardiolipin-lacking yeast mitochondria

2000 • 36 citations

Thyroxine regulation of monolysocardiolipin acyltransferase activity in rat heart

2000 • 36 citations

Barth syndrome without 3‐methylglutaconic aciduria

2004 • 35 citations

Expression of monolysocardiolipin acyltransferase activity is regulated in concert with the level of cardiolipin and cardiolipin biosynthesis in the mammalian heart.

2002 • 35 citations

Preliminary evidence for a cognitive phenotype in Barth syndrome

2001 • 33 citations

Dilated cardiomyopathy due to type II X-linked 3-methylglutaconic aciduria: successful treatment with pantothenic acid.

1994 • 33 citations

Stimulation of cardiac cardiolipin biosynthesis by PPARα activation

2004 • 32 citations

Purification and properties of phosphatidylgkycerophosphate synthetase from mammalian liver mitochondria

1978 • 29 citations

Complex expression pattern of the Barth syndrome gene product tafazzin in human cell lines and murine tissues

2004 • 25 citations

Molecular basis and therapy of disorders associated with chronic neutropenia

2003 • 20 citations

Studies on nucleotide diphosphate diacylglycerol specificity of acidic phospholipid biosynthesis in rat liver subcellular fractions

1976 • 18 citations

Altered subcellular and submitochondrial localization of CTP:phosphatidate cytidylyltransferase in the Morris 7777 hepatoma.

1978 • 14 citations

Long-term treatment of Barth syndrome with pantothenic acid: a retrospective study

2003 • 12 citations

Thyroxine regulation of monolysocardiolipin acyltransferase activity in rat heart

2000 • 10 citations

Rat myocardial tissue lipids and their effect on ventricular electrical activity: influence on dietary lipids

1993 • 9 citations

On the mechanism of the increase in cardiolipin biosynthesis and resynthesis in hepatocytes during rat liver regeneration

2005 • 9 citations