Role of the TMPRSS2-ERG Gene Fusion in Prostate Cancer

Recurrent Fusion of TMPRSS2 and ETS Transcription Factor Genes in Prostate Cancer

2005 • 3,714 citations

Gene expression profiling identifies clinically relevant subtypes of prostate cancer

2004 • 1,292 citations

Integrative molecular concept modeling of prostate cancer progression

2006 • 925 citations

Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer

2007 • 829 citations

Myc-driven murine prostate cancer shares molecular features with human prostate tumors

2003 • 787 citations

TMPRSS2:ERG gene fusion associated with lethal prostate cancer in a watchful waiting cohort

2007 • 645 citations

Prostate Pathology of Genetically Engineered Mice: Definitions and Classification. The Consensus Report from the Bar Harbor Meeting of the Mouse Models of Human Cancer Consortium Prostate Pathology Committee

2004 • 582 citations

Prostate-localized and androgen-regulated expression of the membrane-bound serine protease TMPRSS2.

1999 • 526 citations

TMPRSS2:ERG Fusion-Associated Deletions Provide Insight into the Heterogeneity of Prostate Cancer

2006 • 502 citations

Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse

2001 • 495 citations

Pathological and molecular aspects of prostate cancer

2003 • 474 citations

TMPRSS2:ETV4 Gene Fusions Define a Third Molecular Subtype of Prostate Cancer

2006 • 464 citations

Gene expression profiling predicts clinical outcome of prostate cancer

2004 • 448 citations

TMPRSS2-ERG Fusion Prostate Cancer: An Early Molecular Event Associated With Invasion

2007 • 427 citations

Expression of Variant TMPRSS2/ERG Fusion Messenger RNAs Is Associated with Aggressive Prostate Cancer

2006 • 393 citations

Amiloride selectively inhibits the urokinase‐type plasminogen activator

1987 • 378 citations

Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis

2002 • 320 citations

VCaP, a cell-based model system of human prostate cancer.

2001 • 317 citations

Transcriptional silencing of zinc finger protein 185 identified by expression profiling is associated with prostate cancer progression.

2003 • 312 citations

Comprehensive assessment of TMPRSS2 and ETS family gene aberrations in clinically localized prostate cancer

2007 • 303 citations

c-Myc target gene specificity is determined by a post-DNAbinding mechanism

1998 • 280 citations

Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 Gene Fusions in Prostate Cancer

2008 • 277 citations

Matrix metalloproteinases: roles in cancer and metastasis

2006 • 269 citations

Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by Stat3-C

2004 • 257 citations

TMPRSS2-ERG Gene Fusion Causing ERG Overexpression Precedes Chromosome Copy Number Changes in Prostate Carcinomas, Paired HGPIN Lesions

2006 • 252 citations

Diversity of TMPRSS2-ERG fusion transcripts in the human prostate

2006 • 248 citations

Conditional Loss of Nkx3.1 in Adult Mice Induces Prostatic Intraepithelial Neoplasia

2002 • 235 citations

TMPRSS2 Fusions with Oncogenic ETS Factors in Prostate Cancer Involve Unbalanced Genomic Rearrangements and Are Associated with HDAC1 and Epigenetic Reprogramming

2006 • 235 citations

TMPRSS2:ERG Fusion by Translocation or Interstitial Deletion Is Highly Relevant in Androgen-Dependent Prostate Cancer, But Is Bypassed in Late-Stage Androgen Receptor–Negative Prostate Cancer

2006 • 232 citations

A DNA microarray survey of gene expression in normal human tissues.

2005 • 225 citations

A Small Composite Probasin Promoter Confers High Levels of Prostate-Specific Gene Expression through Regulation by Androgens and Glucocorticoids in Vitro and in Vivo**This work was supported by R01-DK-55748 from the NIH and the Frances Williams Preston Laboratories of the T. J. Martell Foundation. Transgenic mice were bred by the Transgenic Core/ES Cell Shared Resource of the Vanderbilt-Ingram Cancer Center (NCI Grant 2P30-CA-68485–05).

2000 • 222 citations

Evolution of the Androgen Receptor Pathway during Progression of Prostate Cancer

2006 • 217 citations

Three-Color FISH Analysis of TMPRSS2/ERG Fusions in Prostate Cancer Indicates That Genomic Microdeletion of Chromosome 21 Is Associated with Rearrangement

2006 • 184 citations

Frequency of the TMPRSS2:ERG gene fusion is increased in moderate to poorly differentiated prostate cancers

2007 • 178 citations

Expression of TMPRSS2:ERG gene fusion in prostate cancer cells is an important prognostic factor for cancer progression

2007 • 167 citations

Molecular Concepts Analysis Links Tumors, Pathways, Mechanisms, and Drugs

2007 • 145 citations

Molecular Characterization of TMPRSS2-ERG Gene Fusion in the NCI-H660 Prostate Cancer Cell Line: A New Perspective for an Old Model

2007 • 144 citations

Signature-Based Small Molecule Screening Identifies Cytosine Arabinoside as an EWS/FLI Modulator in Ewing Sarcoma

2007 • 137 citations

A variant TMPRSS2 isoform and ERG fusion product in prostate cancer with implications for molecular diagnosis

2007 • 135 citations

Plasminogen Activator Inhibitor-1

2004 • 131 citations

Molecular genetic analyses of the TMPRSS2-ERG and TMPRSS2-ETV1 gene fusions in 50 cases of prostate cancer

2007 • 117 citations

The Ets transcription factors of the PEA3 group: Transcriptional regulators in metastasis

2006 • 114 citations

Expression of the zinc transporter ZnT4 is decreased in the progression from early prostate disease to invasive prostate cancer

2003 • 108 citations

Urokinase-Receptor (u-PAR)–An Essential Player in Multiple Games of Cancer: A Review on Its Role in Tumor Progression, Invasion, Metastasis, Proliferation/dormancy, Clinical Outcome and Minimal Residual Disease

2006 • 91 citations

TARP: A nuclear protein expressed in prostate and breast cancer cells derived from an alternate reading frame of the T cell receptor γ chain locus

2000 • 71 citations

Transcriptomes of human prostate cells

2006 • 68 citations

INTEGRATIVE BIOLOGY OF PROSTATE CANCER PROGRESSION

2006 • 63 citations