Stable parkinsonian syndrome and uneven loss of striatal dopamine fibres following chronic MPTP administration in baboons

A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1983 • 2,149 citations

Uneven Pattern of Dopamine Loss in the Striatum of Patients with Idiopathic Parkinson's Disease

1988 • 1,881 citations

Chronic parkinsonism secondary to intravenous injection of meperidine analogues

1979 • 1,356 citations

Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease

1988 • 1,235 citations

Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyrine (MPTP) in the squirrel monkey

1984 • 913 citations

Recent Developments in Parkinson's Disease

1987 • 552 citations

Hyperactivity of Remaining Dopaminergic Neurones after Partial Destruction of the Nigro-striatal Dopaminergic System in the Rat

1973 • 363 citations

Locus ceruleus lesions and eosinophilic inclusions in MPTP‐treated monkeys

1986 • 347 citations

Hemiparkinsonism in monkeys after unilateral internal carotid artery artery infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

1986 • 309 citations

Effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine on the regional distribution of brain monoamines in the rhesus monkey

1991 • 219 citations

Selective loss of subpopulations of ventral mesencephalic dopaminergic neurons in the monkey following exposure to MPTP

1987 • 163 citations

The effect of fetal mesencephalon implants on primate MPTP-induced parkinsonism

1990 • 145 citations

III. Primate model of parkinsonism: Selective lesion of nigrostriatal neurons by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine produces an extrapyramidal syndrome in rhesus monkeys

1985 • 134 citations

Distinct nigrostriatal projection systems innervate striosomes and matrix in the primate striatum

1989 • 134 citations

Variability and functional recovery in the N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of parkinsonism in monkeys

1986 • 128 citations

Symptomatic and asymptomatic 1 -methyl-4-phenyl-1,2,3,6-tetrahydropyridinetreated primates: Biochemical changes in striatal regions

1989 • 126 citations

Evidence for neuromelanin involvement in MPTP-induced neurotoxicity

1987 • 120 citations

The nigrostriatal system in Parkinson's disease.

1990 • 114 citations

I. Parkinson's disease: Studies with an animal model

1984 • 111 citations

Injury of nigral neurons exposed to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: A tyrosine hydroxylase immunocytochemical study in monkey

1986 • 102 citations

Dopamine fiber detection by [11C]-CFT and PET in a primate model of parkinsonism

1992 • 99 citations

Advances in Neurology, vol 53, Parkinson's Disease: Anatomy, Pathology, and Therapy

1991 • 98 citations

Long-term effects of MPTP on central and peripheral catecholamine and indoleamine concentrations in monkeys

1986 • 91 citations

Effect of chronic treatment of MPTP monkeys with dopamine D-1 and/or D-2 receptor agonists

1990 • 87 citations

The actions of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in animals as a model of Parkinson's disease.

1986 • 86 citations

N-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine (MPTP) causes destruction of the nigrostriatal but not the mesolimbic dopamine system in the monkey.

1984 • 75 citations

The neurotoxicity of 1-methyl-4-phenyl-1,2,3,6,-tetrahydropyridine (mptp) and its relevance to parkinson's disease

1987 • 74 citations

The neurotoxin MPTP does not reproduce in the rhesus monkey the interregional pattern of striatal dopamine loss typical of human idiopathic Parkinson's disease

1988 • 74 citations

The evolution of nigrostriatal neurochemical changes in the MPTP-treated squirrel monkey

1990 • 64 citations

Hemiparkinsonism in monkeys after unilateral caudate nucleus infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): behavior and histology

1988 • 59 citations

The time course and magnitude of spontaneous recovery of parkinsonism produced by intracarotid administration of 1‐Methyl‐4‐Phenyl‐1,2,3,6‐tetrahydropyridine to monkeys

1991 • 54 citations

Neurodegenerative disorders - the role played by endotoxins and xenobiotics.

1988 • 51 citations

Dopamine receptor changes in untreated and (+)-PHNO-treated MPTP parkinsonian primates

1991 • 50 citations

Tremorgenic mechanisms in primates.

1975 • 48 citations

MPTP produces a pattern of nigrostriatal degeneration which coincides with the mosaic organization of the caudate nucleus

1988 • 48 citations

Reversal of the glabellar reflex in Parkinsonism by L-dopa.

1969 • 47 citations

MPTP-induced parkinsonism in monkeys: Mechanism of action, selectivity and pathophysiology

1988 • 42 citations

Electrophysiological evidence for a facio-facial reflex in the facial muscles in man

1977 • 32 citations

Intracarotid 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine Administration: Biochemical and Behavioral Observations in a Primate Model of Hemiparkinsonism

1990 • 32 citations

Tremor in MPTP‐induced parkinsonism

1992 • 32 citations

Stereotaxic lesions and movement disorders in monkeys.

1975 • 30 citations

“In vivo” visualization by positron emission tomography of the progressive striatal dopamine receptor damage occuring in MPTP-intoxicated non-human primates

1986 • 27 citations

Motor impairments and neurochemical changes after unilateral 6-hydroxydopamine lesion of the nigrostriatal dopaminergic system in monkeys

1990 • 25 citations

Nigral degeneration in Parkinson's disease in relation to clinical features

1991 • 24 citations

Behavioral and biochemical studies in monkeys made hemiparkinsonian by MPTP

1987 • 22 citations

Behavioural effects of (+)-4-propyl-9-hydroxynaphthoxazine in primates rendered parkinsonian with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1988 • 19 citations

Habituation of the Blink Reflex

2015 • 17 citations

Subclinical damage to the nigrostriatal dopamine system by MPTP as a model of preclinical Parkinson's disease: A review

1991 • 16 citations

Alterations of the central noradrenergic system in MPTP-induced monkey parkinsonism.

1988 • 13 citations

MPTP and its relevance to parkinson's disease

1987 • 7 citations

Habituation of the blink reflex

1981 • 7 citations

Chronic administration of MPTP to marmosets.

1990 • 5 citations

Analyse électrophysiologique du réflexe de clignement chez l'Homme normal et en clinique neurologique

1972 • 2 citations

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