Symptomatic and asymptomatic 1 -methyl-4-phenyl-1,2,3,6-tetrahydropyridinetreated primates: Biochemical changes in striatal regions

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

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Statistical Principles in Experimental Design

1964 • 8,376 citations

Parallel Organization of Functionally Segregated Circuits Linking Basal Ganglia and Cortex

1986 • 8,208 citations

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

1983 • 4,822 citations

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1973 • 2,615 citations

A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1983 • 2,149 citations

Uneven Pattern of Dopamine Loss in the Striatum of Patients with Idiopathic Parkinson's Disease

1988 • 1,881 citations

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1960 • 1,863 citations

Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity.

1985 • 1,253 citations

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1984 • 1,005 citations

Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyrine (MPTP) in the squirrel monkey

1984 • 913 citations

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1975 • 709 citations

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1985 • 620 citations

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1978 • 556 citations

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1977 • 439 citations

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1977 • 351 citations

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in the common marmoset

1984 • 324 citations

Differential connections of caudate nucleus and putamen in the squirrel monkey (Saimiri sciureus)

1986 • 322 citations

Active uptake of MPP+, a metabolite of MPTP, by brain synaptosomes

1985 • 270 citations

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1986 • 243 citations

The Clinical Syndrome of Striatal Dopamine Deficiency

1985 • 241 citations

The subcortical afferents to caudate nucleus and putamen in primate: A fluorescence retrograde double labeling study

1983 • 230 citations

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonian syndrome in Macaca fascicularis: Which midbrain dopaminergic neurons are lost?

1988 • 197 citations

Aging and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced degeneration of dopaminergic neurons in the substantia nigra

1987 • 185 citations

Selective loss of subpopulations of ventral mesencephalic dopaminergic neurons in the monkey following exposure to MPTP

1987 • 163 citations

Brain neurotransmitter changes in Parkinson's disease

1981 • 157 citations

Sites of the neurotoxic action of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the macaque monkey include the ventral tegmental area and the locus coeruleus

1985 • 155 citations

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1990 • 142 citations

Organization of the ascending striatal afferents in monkeys

1980 • 140 citations

III. Primate model of parkinsonism: Selective lesion of nigrostriatal neurons by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine produces an extrapyramidal syndrome in rhesus monkeys

1985 • 134 citations

Variability and functional recovery in the N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of parkinsonism in monkeys

1986 • 128 citations

Noradrenergic modulation of serotonin synthesis and metabolism. I. Inhibition by clonidine in vivo.

1982 • 126 citations

Herabgesetzte Konzentration der Homovanillinsäure im Gehirn von parkinsonkranken Menschen als Ausdruck der Störung des zentralen Dopaminstoffwechsels

1965 • 126 citations

Human striatal dopamine receptors are organized in compartments.

1986 • 120 citations

Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on catecholamines and metabolites in primate brain and CSF

1987 • 105 citations

Repeated administration of N-methyl-4-phenyl 1,2,5,6-tetrahydropyridine to rats is not toxic to striatal dopamine neurones

1984 • 105 citations

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1986 • 91 citations

Functions of the Basal Ganglia CIBA Foundation Symposium 107

1985 • 76 citations

Preferential vulnerability of A8 dopamine neurons in the primate to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1986 • 72 citations

Differential responsiveness to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in sub-regions of the primate substantia nigra and striatum

1987 • 66 citations

Relation between brain dopamine loss and D2 dopamine receptor density in MPTP monkeys

1988 • 57 citations

Function and dysfunction in the basal ganglia

1990 • 57 citations

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1974 • 41 citations

Striatal bradykinesia alleviated by intracaudate injection ofl-dopa

1968 • 6 citations