Behavioural effects of (+)-4-propyl-9-hydroxynaphthoxazine in primates rendered parkinsonian with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

Parkinsonism

1967 • 11,463 citations

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

1983 • 4,822 citations

Overdependence on degraded gist memory in Alzheimer's disease.

2006 • 4,533 citations

A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1983 • 2,149 citations

Receptor basis for dopaminergic supersensitivity in Parkinson's disease

1978 • 447 citations

Locus ceruleus lesions and eosinophilic inclusions in MPTP‐treated monkeys

1986 • 347 citations

MPTP

1986 • 293 citations

The dopamine autoreceptor agonist B-HT 920 stimulates denervated postsynaptic brain dopamine receptors in rodent and primate models of Parkinson's disease: a novel approach to treatment

1986 • 183 citations

Sites of the neurotoxic action of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the macaque monkey include the ventral tegmental area and the locus coeruleus

1985 • 155 citations

Levodopa-induced dyskinesia and response fluctuations in primates rendered parkinsonian with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

1987 • 113 citations

L-DOPA reverses the elevated density of D2 dopamine receptors in Parkinson's diseased striatum

1985 • 87 citations

Pharmacologic profile of a novel potent direct-acting dopamine agonist, (+)-4-propyl-9-hydroxynaphthoxazine [(+)-PHNO].

1984 • 72 citations

Synthesis of 4-substituted 2H-naphth[1,2-b]-1,4-oxazines, a new class of dopamine agonists

1984 • 59 citations

Recent Advances in Drug Delivery Technology for Neurology

1988 • 41 citations

(+)-4-PROPYL-9-HYDROXYNAPHTHOXAZINE (PHNO), A NEW DOPAMINOMIMETIC, IN TREATMENT OF PARKINSONISM

1985 • 37 citations

Antiparkinsonian activity of (+)-PHNO in the MPTP-treated common marmoset

1987 • 23 citations

Antiparkinsonian activity of single oral dose of PHNO

1987 • 14 citations

Binding of (+)PHNO and other D2-dopamine agonists to D1-dopamine receptors labelled by [3H]SCH 23390

1987 • 9 citations

ChemInform Abstract: SYNTHESIS OF 4‐SUBSTITUTED 2H‐NAPHTH(1,2‐B)‐1,4‐OXAZINES, A NEW CLASS OF DOPAMINE AGONISTS

1985 • 5 citations