Neutron and x-ray scattering studies on the human complement protein properdin provide an analysis of the thrombospondin repeat

Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins

1978 • 4,566 citations

Prediction of the Secondary Structure of Proteins from their Amino Acid Sequence

1979 • 2,930 citations

Structural invariants in protein folding

1975 • 865 citations

Protein volumes and hydration effects. The calculations of partial specific volumes, neutron scattering matchpoints and 280-nm absorption coefficients for proteins and glycoproteins from amino acid sequences

1986 • 575 citations

A new cytokine receptor superfamily

1990 • 506 citations

Properdin: binding to C3b and stabilization of the C3b-dependent C3 convertase.

1975 • 474 citations

A highly conserved amino-acid sequence in thrombospondin, properdin and in proteins from sporozoites and blood stages of a human malaria parasite

1988 • 386 citations

The neutron small-angle camera D11 at the high-flux reactor, Grenoble

1976 • 363 citations

Determination of molecular weight by neutron scattering

1981 • 318 citations

X-ray small angle scattering with substances of biological interest in diluted solutions

1963 • 307 citations

Identification of protein sequence homology by consensus template alignment

1986 • 283 citations

Hydrodynamic properties of macromolecular complexes. I. Translation

1977 • 225 citations

Alternative pathway of complement: recruitment of precursor properdin by the labile C3/C5 convertase and the potentiation of the pathway.

1976 • 204 citations

The structure of human complement component C7 and the C5b-7 complex.

1988 • 199 citations

Properdin, the terminal complement components, thrombospondin and the circumsporozoite protein of malaria parasites contain similar sequence motifs

1988 • 189 citations

The sequence and topology of human complement component C9.

1985 • 179 citations

Nucleotide sequence of cDNA and derived amino acid sequence of human complement component C9.

1984 • 160 citations

Properties of highly purified human properdin.

1968 • 158 citations

Intron–exon splice junctions map at protein surfaces

1982 • 148 citations

Do exons code for structural or functional units in proteins?

1988 • 147 citations

Time-resolved x-ray diffraction station: X-ray optics, detectors, and data acquisition

1989 • 132 citations

Properdin binds to sulfatide [Gal(3-SO4)beta 1-1 Cer] and has a sequence homology with other proteins that bind sulfated glycoconjugates.

1990 • 131 citations

Molecular architecture of human properdin, a positive regulator of the alternative pathway of complement.

1984 • 131 citations

Analysis of the natural polymeric forms of human properdin and their functions in complement activation.

1989 • 118 citations

Incorporation of thrombospondin into fibrin clots.

1985 • 118 citations

Fibronectins: structure, functions and receptors

1989 • 113 citations

Complementary DNA and derived amino acid sequence of the .alpha. subunit of human complement protein C8: evidence for the existence of a separate .alpha. subunit messenger RNA

1987 • 112 citations

Complete primary structure and functional characterization of the sixth component of the human complement system

1989 • 109 citations

Complementary DNA and derived amino acid sequence of the .beta. subunit of human complement protein C8: identification of a close structural and ancestral relationship to the .alpha. subunit and C9

1987 • 106 citations

A study of the structure of human complement component factor H by Fourier transform infrared spectroscopy and secondary structure averaging methods

1988 • 105 citations

Topological mapping of complement component C9 by recombinant DNA techniques suggests a novel mechanism for its insertion into target membranes.

1987 • 101 citations

Low-resolution structural studies of mitochondrial ubiquinol: Cytochrome c reductase in detergent solutions by neutron scattering

1983 • 98 citations

The Molecular Architecture of Human Complement Component C6

1989 • 97 citations

Detecting distant homologies of mosaic proteins

1988 • 93 citations

Hydrodynamics of macromolecular complexes. III. Bacterial viruses

1977 • 82 citations

Complementary DNA cloning of complement C8.beta. and its sequence homology to C9

1987 • 72 citations

Analysis of the interactions between properdin, the third component of complement (C3), and its physiological activation products

1988 • 69 citations

Participation of C3 and its Ligands in Complement Activation

1990 • 66 citations

Molecular modelling of human complement component C3 and its fragments by solution scattering

1986 • 65 citations

Molecular cloning of the cDNA coding for properdin, a positive regulator of the alternative pathway of human complement

1991 • 62 citations

Resolution and analysis of ‘native’ and ‘activated’ properdin

1987 • 60 citations

Characterization of the mouse thrombospondin gene and evaluation of the role of the first intron in human gene expression.

1990 • 55 citations

Structure and chromosomal localization of the human thrombospondin gene

1990 • 54 citations

Structural studies of proteins by high-flux X-ray and neutron solution scattering

1988 • 53 citations

Studies on the sub-unit structure of human properdin

1974 • 53 citations

Structural comparisons of the native and reactive-centre-cleaved forms of α1-antitrypsin by neutron- and X-ray-scattering in solution

1990 • 50 citations

A 34-amino acid peptide of the third component of complement mediates properdin binding.

1988 • 50 citations

Molecular modelling of human complement subcomponent C1q and its complex with C1r2C1s2 derived from neutron-scattering curves and hydrodynamic properties

1985 • 48 citations

Analysis of the interaction between properdin and factor B, components of the alternative-pathway C3 convertase of complement

1988 • 40 citations

[29] Hierarchical method to align large numbers of biological sequences

1990 • 36 citations

Biosynthesis of properdin.

1989 • 31 citations

Structural homology of complement protein C6 with other channel-forming proteins of complement.

1989 • 31 citations

Solid phase radioimmunoassay of properdin

1973 • 30 citations

Mapping of the properdin-binding site in the third component of complement

1984 • 28 citations

Molecular modeling of human complement component C4 and its fragments by x-ray and neutron solution scattering

1990 • 27 citations

Secondary structure in properdin of the complement cascade and related proteins: a study by Fourier transform infrared spectroscopy

1989 • 25 citations

Properdin is a trimer

1982 • 25 citations

Characteristics of a channel plate as an image intensifier for X-ray topography

1976 • 19 citations

Effect of Proteolytic Digestion on the Structure and Function of Human Properdin

1976 • 15 citations

Complete primary structure of human properdin: a positive regulator of the alternative pathway of the serum complement system

1990 • 14 citations

Electron microscopic demonstration of a common structural motif in human complement factor C3 and rat α₁ ‐inhibitor 3 (murinoglobulin)

1990 • 14 citations

[12] Preparation of human properdin

1981 • 7 citations

Molecular modelling strategies in application to complement

1990 • 6 citations