Complete primary structure and functional characterization of the sixth component of the human complement system

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

Improved tools for biological sequence comparison.

1988 • 11,455 citations

Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia

1985 • 9,128 citations

Sequence from picomole quantities of proteins electroblotted onto polyvinylidene difluoride membranes.

1987 • 5,066 citations

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

1986 • 4,785 citations

A new method for predicting signal sequence cleavage sites

1986 • 4,629 citations

A catalogue of splice junction sequences

1982 • 3,861 citations

The scanning model for translation: an update.

1989 • 3,525 citations

A Protein Sequenator

1967 • 2,826 citations

DNA sequence analysis with a modified bacteriophage T7 DNA polymerase.

1987 • 2,266 citations

Cryo-electron microscopy of vitrified specimens

1988 • 2,252 citations

Progressive sequence alignment as a prerequisitetto correct phylogenetic trees

1987 • 1,899 citations

Cryo-electron microscopy of viruses

1984 • 1,293 citations

[47] Establishing homologies in protein sequences

1983 • 1,187 citations

Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor.

1988 • 947 citations

The LDL Receptor Gene: A Mosaic of Exons Shared with Different Proteins

1985 • 845 citations

MOLECULAR ORGANIZATION AND FUNCTION OF THE COMPLEMENT SYSTEM

1988 • 831 citations

Structural requirements of N-glycosylation of proteins. Studies with proline peptides as conformational probes

1983 • 606 citations

Random subcloning of sonicated DNA: Application to shotgun DNA sequence analysis

1983 • 605 citations

The structure of human thrombospondin, an adhesive glycoprotein with multiple calcium-binding sites and homologies with several different proteins.

1986 • 575 citations

Nucleotide sequence of epidermal growth factor cDNA predicts a 128,000-molecular weight protein precursor

1983 • 520 citations

A highly conserved amino-acid sequence in thrombospondin, properdin and in proteins from sporozoites and blood stages of a human malaria parasite

1988 • 386 citations

Acetylcholine receptor binding site contains a disulfide cross-link between adjacent half-cystinyl residues.

1986 • 361 citations

Structure and function of human perforin

1988 • 346 citations

Complete amino acid sequence of human plasma beta 2-glycoprotein I.

1984 • 326 citations

SP-40,40, a newly identified normal human serum protein found in the SC5b-9 complex of complement and in the immune deposits in glomerulonephritis.

1988 • 311 citations

Identification of distinct C3b and C4b recognition sites in the human C3b/C4b receptor (CR1, CD35) by deletion mutagenesis.

1988 • 274 citations

The Ninth Component of Complement and the Pore-Forming Protein (Perforin 1) from Cytotoxic T Cells: Structural, Immunological, and Functional Similarities

1986 • 272 citations

Damage to mammalian cells by proteins that form transmembrane pores

2005 • 269 citations

Homology of perforin to the ninth component of complement (C9)

1988 • 268 citations

Human C3b/C4b receptor (CR1). Demonstration of long homologous repeating domains that are composed of the short consensus repeats characteristics of C3/C4 binding proteins.

1987 • 267 citations

Molecular cloning of S-protein, a link between complement, coagulation and cell-substrate adhesion.

1985 • 241 citations

Epidermal Growth Factor

1973 • 233 citations

Computer-based characterization of epidermal growth factor precursor

1984 • 212 citations

Structural/functional similarity between proteins involved in complement- and cytotoxic T-lymphocyte-mediated cytolysis

1986 • 209 citations

Monoclonal Antibodies Recognizing a Neoantigen of Poly(C9) Detect the Human Terminal Complement Complex in Tissue and Plasma

1985 • 200 citations

The structure of human complement component C7 and the C5b-7 complex.

1988 • 199 citations

Properdin, the terminal complement components, thrombospondin and the circumsporozoite protein of malaria parasites contain similar sequence motifs

1988 • 189 citations

Cassette of Eight Exons Shared by Genes for LDL Receptor and EGF Precursor

1985 • 185 citations

The sequence and topology of human complement component C9.

1985 • 179 citations

The membrane attack mechanism of complement. Isolation and subunit composition of the C5b-9 complex.

1975 • 174 citations

Nucleotide sequence of cDNA and derived amino acid sequence of human complement component C9.

1984 • 160 citations

Detecting homology of distantly related proteins with consensus sequences

1987 • 155 citations

Do exons code for structural or functional units in proteins?

1988 • 147 citations

Complete amino acid sequence of human plasma β_2-glycoprotein I

1984 • 122 citations

Human complement factor I: analysis of cDNA-derived primary structure and assignment of its gene to chromosome 4.

1987 • 120 citations

Characterization of primary amino acid sequence of human complement control protein factor I from an analysis of cDNA clones

1987 • 119 citations

Complementary DNA and derived amino acid sequence of the .alpha. subunit of human complement protein C8: evidence for the existence of a separate .alpha. subunit messenger RNA

1987 • 112 citations

Cloning, analysis, and expression of murine perforin 1 cDNA, a component of cytolytic T-cell granules with homology to complement component C9.

1989 • 110 citations

Complementary DNA and derived amino acid sequence of the .beta. subunit of human complement protein C8: identification of a close structural and ancestral relationship to the .alpha. subunit and C9

1987 • 106 citations

A study of the structure of human complement component factor H by Fourier transform infrared spectroscopy and secondary structure averaging methods

1988 • 105 citations

Topological mapping of complement component C9 by recombinant DNA techniques suggests a novel mechanism for its insertion into target membranes.

1987 • 101 citations

Cytotoxic T lymphocyte mediated cytolysis

1988 • 99 citations

Ultrastructure of the membrane attack complex of complement. Heterogeneity of the complex caused by different degree of C9 polymerization.

1984 • 94 citations

Detecting distant homologies of mosaic proteins

1988 • 93 citations

Complete amino acid sequence of γ‐subunit of the GTP‐binding protein from cattle retina

1985 • 79 citations

Structural Similarities between C6 and C7 of Human Complement

1979 • 72 citations

Complementary DNA cloning of complement C8.beta. and its sequence homology to C9

1987 • 72 citations

Molecular analysis of human complement component C5: localization of the structural gene to chromosome 9

1988 • 69 citations

The Structure and Synthesis of Malformin A

1974 • 68 citations

Isolation and sequence analysis of a cDNA clone encoding the fifth complement component.

1985 • 66 citations

A mechanism for the insertion of complement component C9 into target membranes

1986 • 61 citations

The structure of the mouse lymphocyte pore-forming protein perforin

1989 • 58 citations

A family of killer proteins

1988 • 51 citations

The architecture of complement component C9 and poly(C9).

1985 • 43 citations

Characterization of human complement components C6 and C7

1982 • 37 citations

Assembly of the functional membrane attack complex of human complement: formation of disulfide-linked C9 dimers.

1981 • 37 citations

Structural and functional relationships among receptors and regulators of the complement system

1988 • 36 citations

Biochemical characterization of the sixth component (C6) of human complement

1982 • 36 citations

Mechanisms for the spontaneous formation of covalently linked polymers of the terminal membranolytic complement protein (C9).

1983 • 31 citations

Structural homology of complement protein C6 with other channel-forming proteins of complement.

1989 • 31 citations

Glutathione-catalyzed disulfide-linking of C9 in the membrane attack complex of complement.

1982 • 25 citations

Are proteins made of modules?

1986 • 17 citations

Antithrombin III binding to SC5b-9 attack complexes of human complement: dissociation of a modified antithrombin III derivative subsequent to complex formation

1983 • 10 citations

Biochemical characterization of the human complement protein C6. Association with alpha-thrombin-like enzyme and absence of serine protease activity in cytolytically active C6.

1988 • 6 citations

Identification of a Human C5 β‐Chain Epitope Exposed in the Native Complement Component but Concealed in the SC5b‐9 Complex

1988 • 3 citations