Neurotrophic Strategies for Treating Alzheimer's Disease: Lessons from Basic Neurobiology and Animal Models^a

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1991 • 4,120 citations

Neurotrophin-3: a Neurotrophic Factor Related to NGF and BDNF

1990 • 1,261 citations

Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor

1987 • 1,031 citations

Levels of nerve growth factor and its mRNA in the central nervous system of the rat correlate with cholinergic innervation.

1985 • 941 citations

Neurotrophin-5: A novel neurotrophic factor that activates trk and trkB

1991 • 847 citations

Promotion of central cholinergic and dopaminergic neuron differentiation by brain-derived neurotrophic factor but not neurotrophin 3.

1991 • 610 citations

Neuronal death in the spinal ganglia of the chick embryo and its reduction by nerve growth factor

1981 • 407 citations

Nerve growth factor and Alzheimer's disease

1986 • 378 citations

p140trk mRNA marks NGF-responsive forebrain neurons: Evidence that trk gene expression is induced by NGF

1992 • 371 citations

Human nerve growth factor prevents degeneration of basal forebrain cholinergic neurons in primates

1991 • 190 citations

Recombinant human nerve growth factor infusions prevent cholinergic neuronal degeneration in the adult primate brain

1991 • 184 citations

Potential use of nerve growth factor to treat Alzheimer's disease

1989 • 174 citations

Ciliary neurotrophic factor prevents retrograde neuronal death in the adult central nervous system.

1993 • 130 citations

Choline acetyltransferase messenger RNA expression in developing and adult rat brain: regulation by nerve growth factor

1991 • 110 citations

An evaluation of drugs for improving memory in aged monkeys: implications for clinical trials in humans.

1983 • 77 citations

Cytokines in neural regeneration

1992 • 74 citations

Neurodegenerative disorders; mechanisms and prospects for therapy

1992 • 60 citations

bFGF promotes the survival of entorhinal layer II neurons after perforant path axotomy

1992 • 52 citations

Purification and characterization of a neurite outgrowth factor from chicken gizzard smooth muscle.

1985 • 50 citations

The amyloid proteins of Alzheimer's disease as potential targets for drug therapy

1989 • 38 citations

Neuronal degeneration in human diseases and animal models

1992 • 35 citations

Toward a Third Generation of Cholinesterase Inhibitors

1991 • 7 citations