Pertubations in the Free Energy and Enthalpy of Ionization of Histidine-159 at the Active Site of Papain As Determined by Fluorescence Spectroscopy

DIELECTRIC CONSTANTS OF SOME ORGANIC SOLVENT-WATER MIXTURES AT VARIOUS TEMPERATURES

1932 • 1,211 citations

Interpretation of protein titration curves. Application to lysozyme

1972 • 482 citations

Studies on Coördination Compounds. I. A Method for Determining Thermodynamic Equilibrium Constants in Mixed Solvents^{1, 2}

1953 • 451 citations

Observation of histidine residues in proteins by nuclear magnetic resonance spectroscopy

1975 • 416 citations

Nitrogen-15 nuclear magnetic resonance spectroscopy. The state of histidine in the catalytic triad of .alpha.-lytic protease. Implications for the charge-relay mechanism of peptide-bond cleavage by serine proteases

1978 • 232 citations

Kinetics of Papain-Catalyzed Hydrolysis of α-N-Benzoyl-L-arginine Ethyl Ester and α-N-Benzoyl-L-argininamide¹

1965 • 204 citations

The Complete Amino Acid Sequence of Papain

1970 • 183 citations

The Intrinsic Pk_A-Values of Functional Groups in Enzymes: Improper Deductions from the Ph-Dependence of Steady-State Parameter

1976 • 168 citations

The Ionization Constant of Acetic Acid in Water–Methanol Mixtures at 25° from Conductance Measurements.

1956 • 167 citations

Potentiometric determination of ionizations at the active site of papain

1976 • 127 citations

The Preparation and Properties of trans-Cinnamoyl-Papain¹

1966 • 119 citations

The Effect of Substituents on the Deacylation of Benzoyl-Chymotrypsins

1962 • 113 citations

On the Mode of Activation of the Catalytically Essential Sulfhydryl Group of Papain

1973 • 112 citations

The structure and mechanism of action of papain

1970 • 77 citations

A kinetic and fluorimetric investigation of papain modified at tryptophan -69 and -177 by N–bromosuccinimide

1974 • 60 citations

The fluorescence of papain

1970 • 57 citations

Proton Magnetic Resonance Studies of Human Lysozyme

1969 • 54 citations

The pH dependence of the hydrolysis of benzoyl-L-arginine ethyl ester in cooled mixed solvents.

1975 • 51 citations

Acylation of chymotrypsin by active esters of nonspecific substrates. Evidence for a transient acylimidazole intermediate

1972 • 51 citations

Evidence for conformational restrictions within the active site of acyl papains which influence the rates of hydrolysis

1970 • 47 citations

Acyl substituent effects in the general base catalyzed ammonolysis reactions of esters

1969 • 42 citations

Co‐operative Ionisation of Aspartic‐Acid‐158 and Histidine‐159 in Papain

1976 • 41 citations

The effect of salts upon the pH dependence of the activity of papain and succinyl-papain

1972 • 37 citations

Reaction of papain with α-bromo-β-(5-imidazolyl)propionic acid

1972 • 36 citations

Benzoylamidoacetonitrile as an inhibitor of papain

1973 • 35 citations

Proton Equilibria in the Binding of Zn²⁺ and of Methylmercuric Iodide to Papain

1976 • 34 citations

Dependence of the catalytic activity of papain on the ionization of two acidic groups.

1978 • 29 citations

Solvent-temperature perturbations of ionizable groups as a tool for the investigation of the active site of enzymes.

1975 • 26 citations

Effects of substituents on the rates of deacylation of substituted benzoyl papains. Role of a carboxylate residue in the catalytic mechanism

1978 • 24 citations

Nuclear magnetic resonance titration curves of histidine ring protons. The effect of temperature on ribonuclease A.

1975 • 24 citations

A Spectroscopic Investigation of S‐Trifluoroethylthiopapain

1976 • 20 citations

Proteolytic enzymes. Papain-catalysed hydrolysis of specific aryl esters

1972 • 19 citations

Kinetics and thermodynamics of the reactions of acyl-papains. Effects of pH, temperature, solvents, ionic strength, and added nucleophiles

1971 • 17 citations

Thermodynamics of acid-base equilibriums. III. Ionization of substituted anilinium ions

1973 • 7 citations