Effects of substituents on the rates of deacylation of substituted benzoyl papains. Role of a carboxylate residue in the catalytic mechanism

Tissue sulfhydryl groups

1959 • 25,130 citations

Serine Proteases: Structure and Mechanism of Catalysis

1977 • 1,238 citations

Role of a Buried Acid Group in the Mechanism of Action of Chymotrypsin

1969 • 1,060 citations

An Extended Table of Hammett Substitutent Constants Based on the Ionization of Substituted Benzoic Acids

1958 • 1,035 citations

Structure of Papain

1968 • 473 citations

Binding of chloromethyl ketone substrate analogs to crystalline papain

1976 • 352 citations

Structure of crystalline α-chymotrypsin

1970 • 344 citations

Basicity. Comparison of hydrogen bonding and proton transfer to some Lewis bases

1974 • 216 citations

Kinetics of Papain-Catalyzed Hydrolysis of α-N-Benzoyl-L-arginine Ethyl Ester and α-N-Benzoyl-L-argininamide¹

1965 • 204 citations

Fluorescence and the structure of proteins. I. Effects of substituents on the fluorescence of indole and phenol compounds

1963 • 165 citations

A computer program for fitting data to the Michaelis-Menten equation

1967 • 148 citations

Mercaptide—imidazolium ion‐pair: The reactive nucleophile in papain catalysis

1974 • 139 citations

Potentiometric determination of ionizations at the active site of papain

1976 • 127 citations

The Preparation and Properties of trans-Cinnamoyl-Papain¹

1966 • 119 citations

Phenolic Hydroxyl Ionization in Papain

1961 • 115 citations

The Effect of Substituents on the Deacylation of Benzoyl-Chymotrypsins

1962 • 113 citations

On the Mode of Activation of the Catalytically Essential Sulfhydryl Group of Papain

1973 • 112 citations

Evidence for histidine in the active site of papain

1968 • 105 citations

The Kinetics of the Papain-Catalyzed Hydrolysis of Esters of Carbobenzoxyglycine. Evidence for an Acyl-Enzyme Intermediate^*

1966 • 105 citations

Multiple structure reactivity correlations. Alkaline hydrolyses of acyl and aryl-substituted phenyl benzoates

1968 • 103 citations

A study of the kinetics of the reaction between thiol compounds and chloroacetamide

1960 • 103 citations

The Kinetics and Mechanism of Papain-Catalyzed Hydrolyses¹

1966 • 92 citations

Equilibrium deuterium isotope effects on the ionization of thiol acids

1971 • 85 citations

The structure and mechanism of action of papain

1970 • 77 citations

A detailed structural comparison between the charge relay system in chymotrypsinogen and in α-chymotrypsin

1976 • 59 citations

The fluorescence of papain

1970 • 57 citations

Acylation of chymotrypsin by active esters of nonspecific substrates. Evidence for a transient acylimidazole intermediate

1972 • 51 citations

IV. Cysteine proteinases

1970 • 50 citations

Evidence for conformational restrictions within the active site of acyl papains which influence the rates of hydrolysis

1970 • 47 citations

The chemical modification of papain with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide

1976 • 43 citations

Co‐operative Ionisation of Aspartic‐Acid‐158 and Histidine‐159 in Papain

1976 • 41 citations

Calorimetric and potentiometric characterization of the ionization behavior of ribonuclease A and its complex with 3'-cytosine monophoshate

1975 • 36 citations

Proton Equilibria in the Binding of Zn²⁺ and of Methylmercuric Iodide to Papain

1976 • 34 citations

A comparison of deacylation rates of para-substituted benzoyl-trypsins and chymotrypsins

1972 • 32 citations

Über die Benzoylierung von Imidazol‐Derivaten

1913 • 26 citations

The Influence of pH on the Rate of Hydrolysis of Acylchymotrypsins^*

1966 • 24 citations

A Spectroscopic Investigation of S‐Trifluoroethylthiopapain

1976 • 20 citations

Ionization of a nitrophenol-containing reporter group at the active site of papain

1974 • 20 citations

Kinetics and thermodynamics of the reactions of acyl-papains. Effects of pH, temperature, solvents, ionic strength, and added nucleophiles

1971 • 17 citations

Chemical modification of one carboxyl‐group of papain abolishes the catalytic activity of the enzyme

1974 • 15 citations

The deacylation of substituted benzoyl-α-chymotrypsins

1975 • 12 citations

Activation parameters of elastase and chymotrypsin catalyzed hydrolysis. Differential role of favorable enthalpy in determining reactivity

1973 • 11 citations

On the reaction of papain and succinylpapain with diazo-1-H-tetrazole

1975 • 9 citations

Photooxidation of Histidine and Tryptophan Residues of Papain in the Presence of Methylene Blue1

1975 • 8 citations

Hydrolysis of acylchymotrypsins

1971 • 7 citations

The pK_a value of the active site histidine in photo‐oxidised papain

1976 • 7 citations

Thermodynamics of acid-base equilibriums. III. Ionization of substituted anilinium ions

1973 • 7 citations

Substrate structure effects on the pH dependence of deacylation of acyl-chymotrypsins

1969 • 6 citations

Dimerization of Papain Induced by Mercuric Chloride and a Bifunctional Organic Mercurial

1977 • 6 citations