T-Cell Tropism and the Role of ORF66 Protein in Pathogenesis of Varicella-Zoster Virus Infection

Sequence and structure-based prediction of eukaryotic protein phosphorylation sites

1999 • 3,062 citations

BCL-2 FAMILY: Regulators of Cell Death

1998 • 1,687 citations

Consensus sequences as substrate specificity determinants for protein kinases and protein phosphatases

1991 • 1,327 citations

Varicella-zoster virus

1996 • 1,110 citations

Single Cell Profiling of Potentiated Phospho-Protein Networks in Cancer Cells

2004 • 692 citations

Herpesvirus Assembly and Egress

2002 • 609 citations

Intracellular phospho-protein staining techniques for flow cytometry: Monitoring single cell signaling events

2003 • 553 citations

Analysis of protein phosphorylation and cellular signaling events by flow cytometry: techniques and clinical applications

2004 • 335 citations

Ultrastructural Localization of the Herpes Simplex Virus Type 1 U _L 31, U _L 34, and U _S 3 Proteins Suggests Specific Roles in Primary Envelopment and Egress of Nucleocapsids

2002 • 324 citations

Budding events in herpesvirus morphogenesis

2004 • 277 citations

Egress of Alphaherpesviruses: Comparative Ultrastructural Study

2001 • 273 citations

Herpes simplex virus 1 induces and blocks apoptosis at multiple steps during infection and protects cells from exogenous inducers in a cell-type-dependent manner

1998 • 245 citations

Tropism of varicella-zoster virus for human CD4+ and CD8+ T lymphocytes and epidermal cells in SCID-hu mice

1995 • 231 citations

Attenuation of the Vaccine Oka Strain of Varicella-Zoster Virus and Role of Glycoprotein C in Alphaherpesvirus Virulence Demonstrated in the SCID-hu Mouse

1998 • 219 citations

Varicella-Zoster Virus Transfer to Skin by T Cells and Modulation of Viral Replication by Epidermal Cell Interferon-α

2004 • 214 citations

The herpes simplex virus 1 protein kinase encoded by the US3 gene mediates posttranslational modification of the phosphoprotein encoded by the UL34 gene

1991 • 164 citations

Identification of new protein kinase-related genes in three herpesviruses, herpes simplex virus, varicella-zoster virus, and Epstein-Barr virus

1989 • 163 citations

The U _S 3 protein kinase of herpes simplex virus 1 mediates the posttranslational modification of BAD and prevents BAD-induced programmed cell death in the absence of other viral proteins

2001 • 160 citations

Varicella-Zoster Virus Pathogenesis and Immunobiology: New Concepts Emerging from Investigations with the SCIDhu Mouse Model

2005 • 160 citations

The ORF47 and ORF66 putative protein kinases of varicella-zoster virus determine tropism for human T cells and skin in the SCID-hu mouse

1998 • 154 citations

Effect of the pseudorabies virus US3 protein on nuclear membrane localization of the UL34 protein and virus egress from the nucleus

2001 • 151 citations

Tropism of Varicella-Zoster Virus for Human Tonsillar CD4⁺T Lymphocytes That Express Activation, Memory, and Skin Homing Markers

2002 • 141 citations

Modulation of Major Histocompatibility Class II Protein Expression by Varicella-Zoster Virus

2000 • 137 citations

Varicella-Zoster Virus Retains Major Histocompatibility Complex Class I Proteins in the Golgi Compartment of Infected Cells

2001 • 135 citations

Mutational analysis of the role of glycoprotein I in varicella-zoster virus replication and its effects on glycoprotein E conformation and trafficking

1997 • 129 citations

Identification and Characterization of a Novel Serine– Threonine Kinase Gene from the Xp22 Region

1998 • 128 citations

The HSV-1 Us3 protein kinase is sufficient to block apoptosis induced by overexpression of a variety of Bcl-2 family members

2004 • 113 citations

The U _S 3 Protein Kinase Blocks Apoptosis Induced by the d 120 Mutant of Herpes Simplex Virus 1 at a Premitochondrial Stage

2001 • 102 citations

Modulation of apoptosis during herpes simplex virus infection in human cells

2001 • 94 citations

Herpes Simplex Virus 1 Blocks Caspase-3-Independent and Caspase-Dependent Pathways to Cell Death

1999 • 89 citations

Nuclear Accumulation of IE62, the Varicella-Zoster Virus (VZV) Major Transcriptional Regulatory Protein, Is Inhibited by Phosphorylation Mediated by the VZV Open Reading Frame 66 Protein Kinase

2000 • 85 citations

The Herpes Simplex Virus 1 U _S 3 Protein Kinase Blocks Caspase-Dependent Double Cleavage and Activation of the Proapoptotic Protein BAD

2003 • 78 citations

Infection of Human T Lymphocytes with Varicella-Zoster Virus: an Analysis with Viral Mutants and Clinical Isolates

2000 • 76 citations

Varicella-Zoster Virus ORF47 Protein Serine Kinase: Characterization of a Cloned, Biologically Active Phosphotransferase and Two Viral Substrates, ORF62 and ORF63

2001 • 74 citations

Varicella-Zoster Virus-Infected Human Sensory Neurons Are Resistant to Apoptosis, yet Human Foreskin Fibroblasts Are Susceptible: Evidence for a Cell-Type-Specific Apoptotic Response

2003 • 74 citations

Mutational Analysis of the Repeated Open Reading Frames, ORFs 63 and 70 and ORFs 64 and 69, of Varicella-Zoster Virus

2001 • 73 citations

Construction of Varicella-Zoster Virus Recombinants from Parent Oka Cosmids and Demonstration that ORF65 Protein Is Dispensable for Infection of Human Skin and T Cells in the SCID-hu Mouse Model

2003 • 70 citations

Microarray Analysis of Host Cell Gene Transcription in Response to Varicella-Zoster Virus Infection of Human T Cells and Fibroblasts In Vitro and SCIDhu Skin Xenografts In Vivo

2002 • 69 citations

Determinants for Substrate Phosphorylation by p21-Activated Protein Kinase (γ-PAK)

1997 • 64 citations

Bcl-2 Blocks a Caspase-Dependent Pathway of Apoptosis Activated by Herpes Simplex Virus 1 Infection in HEp-2 Cells

2000 • 59 citations

Virion Association of IE62, the Varicella-Zoster Virus (VZV) Major Transcriptional Regulatory Protein, Requires Expression of the VZV Open Reading Frame 66 Protein Kinase

2001 • 56 citations

Putative site for the acquisition of human herpesvirus 6 virion tegument

1990 • 54 citations

Promoter Sequences of Varicella-Zoster Virus Glycoprotein I Targeted by Cellular Transactivating Factors Sp1 and USF Determine Virulence in Skin and T Cells in SCIDhu Mice In Vivo

2002 • 53 citations

The varicella-zoster virus ORF66 protein induces kinase activity and is dispensable for viral replication

1996 • 52 citations

Characterization of the putative protein kinases specified by varicella-zoster virus genes 47 and 66

1994 • 47 citations

Differential Requirement for Cell Fusion and Virion Formation in the Pathogenesis of Varicella-Zoster Virus Infection in Skin and T Cells

2004 • 45 citations

Assessment of MRI criteria for MS in Japanese MS and HAM/TSP

1995 • 35 citations

Analysis of the Glycoproteins I and E of Varicella‐Zoster Virus (VZV) using Deletional Mutations of VZV Cosmids

1998 • 32 citations

Identification of the US3 gene product of BHV-1 as a protein kinase and characterization of BHV-1 mutants of the US3 gene

1999 • 31 citations

Cis and trans elements regulating expression of the varicella zoster virus gI gene

2001 • 19 citations

Interactions between varicella-zoster virus IE62 and cellular transcription factor USF in the coordinate activation of genes 28 and 29

1995 • 19 citations

Comparison of varicella-zoster virus ORF47 protein kinase and casein kinase II and their substrates

2003 • 19 citations