The HSV-1 Us3 protein kinase is sufficient to block apoptosis induced by overexpression of a variety of Bcl-2 family members

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Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

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Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

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Inhibition of ICE Family Proteases by Baculovirus Antiapoptotic Protein p35

1995 • 645 citations

Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase‐1 and p70 S6 kinase

1996 • 631 citations

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1992 • 614 citations

Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein

1995 • 467 citations

A Bcl-2 homolog encoded by Kaposi sarcoma-associated virus, human herpesvirus 8, inhibits apoptosis but does not heterodimerize with Bax or Bak

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Herpes simplex virus resistance to antiviral drugs

2003 • 423 citations

Bax and other pro-apoptotic Bcl-2 family "killer-proteins" and their victim the mitochondrion

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BAD Ser-155 Phosphorylation Regulates BAD/Bcl-XL Interaction and Cell Survival

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14-3-3 proteins; bringing new definitions to scaffolding

2001 • 298 citations

U _L 31 and U _L 34 Proteins of Herpes Simplex Virus Type 1 Form a Complex That Accumulates at the Nuclear Rim and Is Required for Envelopment of Nucleocapsids

2001 • 290 citations

Bcl‐2 overexpression protects against neuron loss within the ischemic margin following experimental stroke and inhibits cytochrome c translocation and caspase‐3 activity

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Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155

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The herpes simplex virus 1 protein kinase U _S 3 is required for protection from apoptosis induced by the virus

1997 • 271 citations

Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway

1999 • 258 citations

Growth Factors Inactivate the Cell Death Promoter BAD by Phosphorylation of Its BH3 Domain on Ser155

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Functional complementation of the adenovirus E1B 19-kilodalton protein with Bcl-2 in the inhibition of apoptosis in infected cells

1994 • 225 citations

Herpes Simplex Virus Inhibits Apoptosis through the Action of Two Genes, Us5 and Us3

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Molecular Phylogeny of the Alphaherpesvirinae Subfamily and a Proposed Evolutionary Timescale

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Herpes simplex virus 1 protein kinase is encoded by open reading frame US3 which is not essential for virus growth in cell culture

1987 • 192 citations

Herpes Simplex Virus Type 1 Primary Envelopment: UL34 Protein Modification and the US3-UL34 Catalytic Relationship

2003 • 165 citations

The U _S 3 protein kinase of herpes simplex virus 1 mediates the posttranslational modification of BAD and prevents BAD-induced programmed cell death in the absence of other viral proteins

2001 • 160 citations

Epstein-Barr Virus Encodes a Novel Homolog of thebcl-2Oncogene That Inhibits Apoptosis and Associates with Bax and Bak

1999 • 158 citations

Phosphorylation of the pro-apoptotic protein BAD on serine 155, a novel site, contributes to cell survival

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Effect of the pseudorabies virus US3 protein on nuclear membrane localization of the UL34 protein and virus egress from the nucleus

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Alphaherpesviruses possess a gene homologous to the protein kinase gene family of eukaryotes and retroviruses

1986 • 139 citations

Physiological significance of apoptosis in animal virus infection

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Herpesvirus saimiri encodes a functional homolog of the human bcl-2 oncogene

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The US3-encoded protein kinase from pseudorabies virus affects egress of virions from the nucleus

1995 • 116 citations

Caspase Cleavage Enhances the Apoptosis-Inducing Effects of BAD

2001 • 115 citations

The U _S 3 Protein Kinase Blocks Apoptosis Induced by the d 120 Mutant of Herpes Simplex Virus 1 at a Premitochondrial Stage

2001 • 102 citations

US3 protein kinase of herpes simplex virus type 2 plays a role in protecting corneal epithelial cells from apoptosis in infected mice.

1999 • 88 citations

The Herpes Simplex Virus 1 U _S 3 Protein Kinase Blocks Caspase-Dependent Double Cleavage and Activation of the Proapoptotic Protein BAD

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The substrate specificity of the protein kinase induced in cells infected with herpesviruses: Studies with synthetic substatres indicate structural requirements distinct from other protein kinases

1986 • 71 citations

Inactivation of Glycoprotein gE and Thymidine Kinase or the US3-Encoded Protein Kinase Synergistically Decreases in Vivo Replication of Pseudorabies Virus and the Induction of Protective Immunity

1994 • 63 citations

Further definition of the substrate specificity of the alpha-herpesvirus protein kinase and comparison with protein kinases A and C

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US3 protein kinase of herpes simplex virus protects primary afferent neurons from virus-induced apoptosis in ICR mice

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HSV vector-mediated gene delivery to the central nervous system.

2001 • 23 citations

BAD Induces Apoptosis in Cells Over-Expressing Bcl-2 or Bcl-xL without Loss of Mitochondrial Membrane Potential

2001 • 18 citations

The antiviral xanthate compound D609 inhibits herpes simplex virus type 1 replication and protein phosphorylation

1997 • 15 citations