Microvascular Responses to Cerebral Ischemia/Inflammation^a

Oxygen-Derived Free Radicals in Postischemic Tissue Injury

1985 • 5,488 citations

Requirement of Vascular Integrin α _v β ₃ for Angiogenesis

1994 • 3,016 citations

Thresholds in cerebral ischemia - the ischemic penumbra.

1981 • 2,780 citations

Leukocytes roll on a selectin at physiologic flow rates: Distinction from and prerequisite for adhesion through integrins

1991 • 2,195 citations

Endothelial Expression of a Mononuclear Leukocyte Adhesion Molecule During Atherogenesis

1991 • 1,703 citations

The Emerging Concept of Vascular Remodeling

1994 • 1,563 citations

A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1.

1986 • 1,428 citations

Neurological Deficit and Extent of Neuronal Necrosis Attributable to Middle Cerebral Artery Occlusion in Rats

1995 • 1,381 citations

Cortical evoked potential and extracellular K+ and H+ at critical levels of brain ischemia.

1977 • 1,093 citations

NEW CYTOPLASMIC COMPONENTS IN ARTERIAL ENDOTHELIA

1964 • 1,062 citations

Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice

1993 • 1,058 citations

GMP-140, a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies.

1989 • 993 citations

Two-step model of leukocyte-endothelial cell interaction in inflammation: distinct roles for LECAM-1 and the leukocyte beta 2 integrins in vivo.

1991 • 977 citations

Selectins.

1993 • 869 citations

Osteopontin--a possible anchor of osteoclasts to bone.

1990 • 816 citations

Tumor necrosis factor-alpha expression in ischemic neurons.

1994 • 793 citations

Platelet Glycoprotein IIb/IIIa Receptors in Cardiovascular Medicine

1995 • 769 citations

Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboons.

1991 • 741 citations

A form of circulating ICAM-1 in human serum.

1991 • 700 citations

Leukocyte Trafficking Mediated by Selectin-Carbohydrate Interactions

1995 • 648 citations

Oxygen radicals induce human endothelial cells to express GMP-140 and bind neutrophils.

1991 • 605 citations

Biosynthetic and functional properties of an Arg-Gly-Asp-directed receptor involved in human melanoma cell attachment to vitronectin, fibrinogen, and von Willebrand factor.

1987 • 574 citations

A monoclonal antibody to the membrane glycoprotein complex CD18 inhibits polymorphonuclear leukocyte accumulation and plasma leakage in vivo

1987 • 525 citations

Influx of leukocytes and platelets in an evolving brain infarct (Wistar rat).

1994 • 491 citations

Correlation between myeloperoxidase-quantified neutrophil accumulation and ischemic brain injury in the rat. Effects of neutrophil depletion.

1994 • 485 citations

Cell attachment to thrombospondin: the role of ARG-GLY-ASP, calcium, and integrin receptors.

1988 • 481 citations

Polymorphonuclear leukocyte accumulation in brain regions with low blood flow during the early postischemic period.

1986 • 474 citations

Neuroprotective Effects of Human Recombinant Interleukin-1 Receptor Antagonist in Focal Cerebral Ischaemia in the Rat

1996 • 456 citations

In vivo neutralization of P-selectin protects feline heart and endothelium in myocardial ischemia and reperfusion injury.

1993 • 452 citations

Greenfield's Neuropathology

1993 • 445 citations

P-selectin and intercellular adhesion molecule-1 expression after focal brain ischemia and reperfusion.

1994 • 428 citations

Endothelial cell-associated platelet-activating factor: a novel mechanism for signaling intercellular adhesion.

1990 • 391 citations

Monocyte rolling, arrest and spreading on IL-4-activated vascular endothelium under flow is mediated via sequential action of L-selectin, beta 1-integrins, and beta 2-integrins.

1994 • 391 citations

Neutrophil-dependent acute lung injury. Requirement for P-selectin (GMP-140).

1992 • 385 citations

Cloning of the mouse endothelial selectins. Expression of both E- and P-selectin is inducible by tumor necrosis factor alpha.

1992 • 383 citations

Microvascular Basal Lamina Antigens Disappear During Cerebral Ischemia and Reperfusion

1995 • 369 citations

Inhibition of polymorphonuclear leukocyte adherence suppresses no-reflow after focal cerebral ischemia in baboons.

1992 • 368 citations

Anti‐ICAM‐1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in the rat

1994 • 360 citations

The particulate superoxide-forming system from human neutrophils. Properties of the system and further evidence supporting its participation in the respiratory burst.

1976 • 350 citations

Interleukin-1 beta mRNA expression in ischemic rat cortex.

1993 • 335 citations

Human monocytes bind to two cytokine-induced adhesive ligands on cultured human endothelial cells: endothelial-leukocyte adhesion molecule-1 and vascular cell adhesion molecule-1

1991 • 318 citations

Upregulation of intercellular adhesion molecule-1 (ICAM-1) expression in primary cultures of human brain microvessel endothelial cells by cytokines and lipopolysaccharide

1992 • 302 citations

Antibody to CD-18 exerts endothelial and cardiac protective effects in myocardial ischemia and reperfusion.

1991 • 296 citations

Coronary endothelial and cardiac protective effects of a monoclonal antibody to intercellular adhesion molecule-1 in myocardial ischemia and reperfusion.

1992 • 296 citations

Hemorrhagic Transformation and Microvascular Integrity during Focal Cerebral Ischemia/Reperfusion

1996 • 291 citations

The vitronectin receptor alpha v beta 3 binds fibronectin and acts in concert with alpha 5 beta 1 in promoting cellular attachment and spreading on fibronectin.

1990 • 282 citations

Concomitant cortical expression of TNF-α and IL-1β mRNAs follows early response gene expression in transient focal ischemia

1994 • 278 citations

Local immune responses in the rat cerebral cortex after middle cerebral artery occlusion

1994 • 268 citations

Selectins: Novel Receptors that Mediate Leukocyte Adhesion During Inflammation

1991 • 264 citations

The Weibel-Palade Body: the Storage Granule for von Willebrand Factor and P-selectin

1993 • 262 citations

Quantitative venographic assessment of deep vein thrombosis in the evaluation of streptokinase and heparin therapy.

1977 • 262 citations

Initiation of Coagulation by Tissue Facto

1988 • 258 citations

Leukocyte rolling in vivo is mediated by P-selectin glycoprotein ligand- 1

1995 • 258 citations

Role of cell adhesion molecules in brain injury after transient middle cerebral artery occlusion in the rat

1994 • 257 citations

Monoclonal antibody to L-selectin attenuates neutrophil accumulation and protects ischemic reperfused cat myocardium.

1993 • 238 citations

Complete sequence of the human tissue factor gene, a highly regulated cellular receptor that initiates the coagulation protease cascade

1989 • 217 citations

Fibrin contributes to microvascular obstructions and parenchymal changes during early focal cerebral ischemia and reperfusion.

1994 • 207 citations

Production and effects of platelet-activating factor in the rat brain

1988 • 205 citations

Requirements for tumor necrosis factor-alpha and interleukin-1 in limb ischemia/reperfusion injury and associated lung injury.

1993 • 198 citations

Absence of trauma-induced leukocyte rolling in mice deficient in both P-selectin and intercellular adhesion molecule 1.

1996 • 195 citations

Temporary Occlusion of the Middle Cerebral Artery in the Monkey: Clinical and Pathological Observations

1970 • 191 citations

Physiology and pathophysiology of leukocyte adhesion

1995 • 188 citations

Expression of Interleukin-6, c-Fos, and zif268 mRNAs in Rat Ischemic Cortex

1995 • 179 citations

Experimental acute thrombotic stroke in baboons.

1986 • 178 citations

Circulating Selectin- and Immunoglobulin-Type Adhesion Molecules in Acute Ischemic Stroke

1995 • 172 citations

Effects of neutrophil-derived oxidants on intestinal permeability, electrolyte transport, and epithelial cell viability

1990 • 170 citations

Human microvascular endothelial cells use beta 1 and beta 3 integrin receptor complexes to attach to laminin.

1990 • 155 citations

The temporal profiles of ICAM-1 protein and mRNA expression after transient MCA occlusion in the rat

1995 • 149 citations

Platelet‐activating factor in stroke and brain injury

1991 • 149 citations

Role of beta 1, beta 2 integrins and ICAM-1 in lung injury after deposition of IgG and IgA immune complexes.

1993 • 149 citations

The role of neutrophils and platelets in a rabbit model of thromboembolic stroke.

1991 • 146 citations

Role of selectins in local and remote tissue injury following ischemia and reperfusion.

1994 • 143 citations

Endothelial activation by hydrogen peroxide. Selective increases of intercellular adhesion molecule-1 and major histocompatibility complex class I.

1993 • 142 citations

The Regulation of Platelet-activating Factor Production in Endothelial Cells

1989 • 141 citations

E-Selectin Appears in Nonischemic Tissue During Experimental Focal Cerebral Ischemia

1996 • 139 citations

Upregulation of intercellular adhesion molecule 1 (ICAM-1) on brain microvascular endothelial cells in rat ischemic cortex

1994 • 136 citations

Integrin alphavbeta3 is expressed in selected microvessels after focal cerebral ischemia.

1996 • 113 citations

Cytochemical detection of superoxide in cerebral inflammation and ischemia in vivo

1992 • 110 citations

Evidence for platelet-activating factor as a novel mediator in experimental stroke in rabbits.

1990 • 106 citations

Time-related changes in myeloperoxidase activity and leukotriene B4 receptor binding reflect leukocyte influx in cerebral focal stroke

1995 • 106 citations

Tissue factor contributes to microvascular defects after focal cerebral ischemia.

1993 • 101 citations

Demonstration of Increased Endothelial-Leukocyte Adhesion Molecule–1 mRNA Expression in Rat Ischemic Cortex

1995 • 99 citations

Structure, function and biological properties of integrin ?v?3on human melanoma cells

1991 • 97 citations

Production of Platelet‐Activating Factor from Rat Cerebellar Granule Cells in Culture

1990 • 92 citations

In vivo visualization of oxidative changes in microvessels during neutrophil activation

1993 • 89 citations

Increased expression of ICAM-1 during reoxygenation in brain endothelial cells.

1994 • 85 citations

Na channel kinetics remain stable during perforated-patch recordings

1992 • 80 citations

Tissue Factor Localization in Non-Human Primate Cerebral Tissue

1992 • 75 citations

ICAM-1 expression on human brain microvascular endothelial cells

1994 • 75 citations

Impaired microvascular filling after focal cerebral ischemia in the monkey

1972 • 73 citations

Histologic assessment of neurons in rat models of cerebral ischemia.

1990 • 72 citations

Leukocyte biophysics

1990 • 33 citations

The role of adhesion molecules in reperfusion injury.

1993 • 28 citations

Leukocyte kinetics in the microcirculation

1987 • 26 citations

Introduction to Neuropathology

1969 • 20 citations

P‐Selectin Knockout: A Mouse Model for Various Human Diseases

2007 • 12 citations

Creation and Characterization of E‐Selectin‐ and VCAM‐1‐Deficient Mice

2007 • 12 citations

Species differences in platelet aggregation induced by platelet-activating factor (PAF).

1992 • 11 citations

Experimental Cerebral Infarction in the Dog

1986 • 8 citations

Experimental cerebral infarction in the dog. Ultrastructural study of microvessels in subacute cerebral infarction.

1987 • 8 citations

Experimental Cerebral Infarction in the Dog

1978 • 5 citations