Initiation of Coagulation by Tissue Facto

A simple method for displaying the hydropathic character of a protein

1982 • 22,471 citations

Tumors: Wounds That Do Not Heal

1986 • 4,202 citations

A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation

1986 • 4,200 citations

Molecular weight analysis of oligopeptides by electrophoresis in polyacrylamide gel with sodium dodecyl sulfate

1971 • 1,736 citations

Identification of a common nucleotide sequence in the 3'-untranslated region of mRNA molecules specifying inflammatory mediators.

1986 • 1,591 citations

The human LDL receptor: A cysteine-rich protein with multiple Alu sequences in its mRNA

1984 • 1,386 citations

Modulation of endothelial cell hemostatic properties by tumor necrosis factor.

1986 • 1,335 citations

An Enzyme Cascade in the Blood Clotting Mechanism, and its Function as a Biochemical Amplifier

1964 • 1,099 citations

Waterfall Sequence for Intrinsic Blood Clotting

1964 • 1,088 citations

Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterization and comparison with the actions of interleukin 1.

1986 • 1,079 citations

Characterization of the human factor VIII gene

1984 • 983 citations

Membrane Asymmetry

1977 • 965 citations

Interleukin 1 (IL-1) induces biosynthesis and cell surface expression of procoagulant activity in human vascular endothelial cells.

1984 • 944 citations

Tissue factor and hemostasis [published erratum appears in Blood 1988 Apr;71(4):1178]

1988 • 941 citations

Molecular cloning of a cDNA encoding human antihaemophilic factor

1984 • 937 citations

Mechanisms for the incorporation of proteins in membranes and organelles.

1982 • 875 citations

Activation of factor IX by the reaction product of tissue factor and factor VII: additional pathway for initiating blood coagulation.

1977 • 791 citations

Activation of blood coagulation in cancer: Trousseau's syndrome revisited

1983 • 676 citations

The Macrophage as an Effector Cell

1980 • 628 citations

Base sequence studies of 300 nucleotide renatured repeated human DNA clones

1981 • 605 citations

Interleukin 1 induces endothelial cell procoagulant while suppressing cell-surface anticoagulant activity.

1986 • 592 citations

Activation of blood coagulation in cancer: Trousseau's syndrome revisited

1983 • 590 citations

Progress in Clinical and Biological Research

1984 • 554 citations

Endotoxin enhances tissue factor and suppresses thrombomodulin expression of human vascular endothelium in vitro.

1987 • 467 citations

Characterization of a cDNA coding for human factor VII.

1986 • 450 citations

Bleeding and thrombosis in the myeloproliferative disorders

1984 • 428 citations

Isolation and characterization of a cDNA coding for human factor IX.

1982 • 415 citations

The Endotoxin‐induced Coagulant Activity of Human Monocytes

1975 • 382 citations

The J. D. mutation in familial hypercholesterolemia: Amino acid substitution in cytoplasmic domain impedes internalization of LDL receptors

1986 • 372 citations

Monoclonal immunoglobulin M lambda coagulation inhibitor with phospholipid specificity. Mechanism of a lupus anticoagulant.

1980 • 367 citations

Thrombosis and haemostasis

1988 • 327 citations

Molecular cloning of the cDNA for tissue factor, the cellular receptor for the initiation of the coagulation protease cascade

1987 • 318 citations

Increased Tissue Thromboplastin Activity in Monocytes of Patients with Meningococcal Infection: Related to an Unfavourable Prognosis

1983 • 311 citations

Membrane asymmetry and blood coagulation

1977 • 309 citations

Characterization of the complementary deoxyribonucleic acid and gene coding for human prothrombin

1983 • 299 citations

Interleukin-1 activation of vascular endothelium. Effects on procoagulant activity and leukocyte adhesion.

1985 • 295 citations

Fibrin as a component of the tumor stroma: origins and biological significance

1983 • 265 citations

The coagulation-kinin pathway of human plasma

1987 • 263 citations

Role of plasma, platelets, and endothelial cells in tumor metastasis

1984 • 260 citations

Factor VII binding to tissue factor in reconstituted phospholipid vesicles: induction of cooperativity by phosphatidylserine

1986 • 259 citations

Isolation of cDNA clones coding for human tissue factor: primary structure of the protein and cDNA.

1987 • 251 citations

Covalent binding of fatty acid to the transferrin receptor in cultured human cells.

1981 • 246 citations

Purification and properties of human coagulation factor VII.

1980 • 238 citations

Die Chemie der Blutgerinnung

1905 • 230 citations

Human placental anticoagulant protein: isolation and characterization

1987 • 228 citations

A factor X-activating cysteine protease from malignant tissue.

1981 • 221 citations

The coagulation-kinin pathway of human plasma

1987 • 218 citations

Kinetics of the activation of bovine coagulation factor X by components of the extrinsic pathway. Kinetic behavior of two-chain factor VII in the presence and absence of tissue factor

1977 • 216 citations

Activation and control of factor VII by activated factor X and thrombin. Isolation and characterization of a single chain form of factor VII

1975 • 215 citations

Human thrombomodulin: complete cDNA sequence and chromosome localization of the gene

1987 • 209 citations

Tissue-factor coagulant activity of cultured human endothelial and smooth muscle cells and fibroblasts

1977 • 205 citations

Isolation and characterization of human factor VII. Activation of factor VII by factor Xa.

1981 • 201 citations

Studies of a mechanism inhibiting the initiation of the extrinsic pathway of coagulation

1987 • 200 citations

Acylation of bovine rhodopsin by [3H]palmitic acid.

1984 • 200 citations

Two classes of fatty acid acylated proteins exist in eukaryotic cells.

1985 • 196 citations

Purification and characterization of bovine tissue factor.

1981 • 196 citations

C5 chemotactic fragment induces leukocyte production of tissue factor activity: a link between complement and coagulation.

1979 • 194 citations

Human tissue factor: cDNA sequence and chromosome localization of the gene

1987 • 189 citations

Cloning of a cDNA coding for human factor V, a blood coagulation factor homologous to factor VIII and ceruloplasmin.

1986 • 187 citations

Purification and characterization of human coagulation factor V.

1981 • 187 citations

Procoagulant activity associated with plasma membrane vesicles shed by cultured tumor cells.

1983 • 184 citations

Association of tissue factor activity with the surface of cultured cells.

1975 • 182 citations

Binding of human factor VII and VIIa to monocytes.

1982 • 176 citations

Isolation and characterization of antistasin. An inhibitor of metastasis and coagulation.

1987 • 175 citations

Thrombosis and cancer

1987 • 170 citations

A Correlation between Surface Charge and Coagulant Action of Phospholipids

1961 • 169 citations

Antibody and immune complexes induce tissue factor production by human endothelial cells.

1986 • 164 citations

Hereditary factor VII deficiency: heterogeneity defined by combined functional and immunochemical analysis

1985 • 164 citations

Tissue-factor coagulant activity of cultured human endothelial and smooth muscle cells and fibroblasts

1977 • 161 citations

Mononuclear cell tissue factor: cell of origin and requirements for activation

1979 • 160 citations

Acylation of disc membrane rhodopsin may be nonenzymatic.

1987 • 159 citations

Kinetics of factor IX activation via the extrinsic pathway. Dependence of Km on tissue factor.

1980 • 157 citations

Inhibition of tissue factor/factor VIIa activity in plasma requires factor X and an additional plasma component

1985 • 155 citations

Factor VII deficiency

1981 • 153 citations

The phospholipid requirement of tissue factor in blood coagulation

1968 • 151 citations

Purification of human brain tissue factor.

1985 • 151 citations

Activation of bovine factor VII by hageman factor fragments

1977 • 150 citations

Complete amino acid sequence of streptokinase and its homology with serine proteases

1982 • 143 citations

Stimulation of Human Leukocyte Thromboplastic Activity by Endotoxin

1971 • 141 citations

Characterization of the inhibition of tissue factor in serum

1987 • 134 citations

THE ACTIVE PRINCIPLE OF PLACENTAL TOXIN: THROMBOPLASTIN; ITS INACTIVATOR IN BLOOD: ANTITHROMBOPLASTIN

1947 • 132 citations

Tissue factor accelerates the activation of coagulation factor VII: The role of a bifunctional coagulation cofactor

1985 • 132 citations

Characterization of a complementary deoxyribonucleic acid coding for the .gamma. chain of human fibrinogen

1983 • 132 citations

Mechanism of activation of bovine factor VII. Products of cleavage by factor Xa.

1976 • 129 citations

Quantitation of factor VII in the plasma of normal and warfarin-treated individuals by radioimmunoassay

1983 • 128 citations

Characterization of complementary deoxyribonucleic acid and genomic deoxyribonucleic acid for the .beta. chain of human fibrinogen

1983 • 126 citations

Characterization of a thrombomodulin cDNA reveals structural similarity to the low density lipoprotein receptor.

1986 • 125 citations

The role of human T cells (and T cell products) for monocyte tissue factor generation.

1980 • 125 citations

Activation of blood coagulation in Crohn's disease. Increased plasma fibrinopeptide A levels and enhanced generation of monocyte tissue factor activity.

1987 • 124 citations

An ordered addition, essential activation model of the tissue factor pathway of coagulation: evidence for a conformational cage

1986 • 121 citations

Isolation and characterization of bovine factor VII

1975 • 118 citations

Tissue Thromboplastin Activity of Isolated Human Monocytes

1978 • 111 citations

An inhibitory monoclonal antibody against human tissue factor

1987 • 107 citations

THE NATURE AND ACTION OF THE THROMBOPLASTIC (ZYMOPLASTIC) SUBSTANCE OF THE TISSUES

1912 • 102 citations

Studies on the attachment of myristic and palmitic acid to cell proteins in human squamous carcinoma cell lines: evidence for two pathways.

1985 • 100 citations

Isolation of the tissue factor inhibitor produced by HepG2 hepatoma cells.

1987 • 100 citations

Leukocyte procoagulant activity in man: an in vitro correlate of delayed-type hypersensitivity.

1982 • 100 citations

Enhancement of mononuclear procoagulant activity by platelet 12-hydroxyeicosatetraenoic acid.

1986 • 97 citations

Intermediate reactions in the coagulation of blood with tissue thromboplastin; convertin, accelerin, prothrombinase.

1957 • 97 citations

Activation of blood coagulation in Crohn's disease

1987 • 95 citations

Affinity purification of human tissue factor: interaction of factor VII and tissue factor in detergent micelles.

1986 • 95 citations

Phospholipase C from Bacillus cereus and Its Use in Studies of Tissue Thromboplastin

1972 • 93 citations

The dual role of factor VII in blood coagulation. Initiation and inhibition of a proteolytic system by a zymogen.

1982 • 91 citations

The assembly of blood clotting complexes on membranes

1987 • 91 citations

Plasma Lipoprotein Induction and Suppression of the Generation of Cellular Procoagulant Activity In Vitro

1981 • 91 citations

Partial mRNA sequences for human A alpha, B beta, and gamma fibrinogen chains: evolutionary and functional implications.

1983 • 88 citations

Tissue factor induction in human monocytes. Two distinct mechanisms displayed by different alloantigen-responsive T cell clones.

1985 • 87 citations

Characterization of a complementary deoxyribonucleic acid coding for the .alpha. chain of human fibrinogen

1983 • 87 citations

Zymogens and Cofactors of Blood Coagulatio

1980 • 86 citations

Kinetics of the tissue factor-dependent activation of coagulation Factors IX and X in a bovine plasma system.

1979 • 85 citations

An inhibitory monoclonal antibody against human tissue factor

1987 • 83 citations

Purification and some properties of the protein component of tissue thromboplastin from human brain

1977 • 83 citations

Monocyte procoagulant inducing factor: a lymphokine involved in the T cell-instructed monocyte procoagulant response to antigen.

1986 • 83 citations

THEORIES OF BLOOD COAGULATION

1935 • 81 citations

Plasma Lipoprotein Induction and Suppression of the Generation of Cellular Procoagulant Activity in Vitro

1981 • 81 citations

Quantitation of fibrinogen influx and fibrin deposition and turnover in line 1 and line 10 guinea pig carcinomas.

1984 • 80 citations

Inhibitor of the factor VIIa-tissue factor complex is reduced in patients with disseminated intravascular coagulation but not in patients with severe hepatocellular disease.

1987 • 80 citations

Activation of human factor VII by activated factors IX and X

1982 • 76 citations

A simple procedure for removing contaminating aldehydes and peroxides from aqueous solutions of polyethylene glycols and of nonionic detergents that are based on the polyoxyethylene linkage

1985 • 74 citations

Activation of human factor VII in the initiation of tissue factor- dependent coagulation

1986 • 72 citations

Cooperative interaction between factor VII and cell surface-expressed tissue factor.

1987 • 72 citations

Lipid A as the biologically active moiety in bacterial endotoxin (LPS)- initiated generation of procoagulant activity by peripheral blood leukocytes

1977 • 70 citations

Tissue factor-dependent activation of tritium-labeled factor IX and factor X in human plasma

1984 • 70 citations

In vitro stimulation of tissue thromboplastin (factor III) activity in human monocytes by immune complexes and lectins

1979 • 69 citations

Species Specificity of Tissue Thromboplastin

1984 • 69 citations

Comparison of Procoagulant Activities in Extracts of Normal and Malignant Human Tissue<xref ref-type="fn" rid="FN2">2</xref>

1979 • 69 citations

Concanavalin A inhibits tissue factor coagulant activity.

1975 • 69 citations

Nucleotide sequence of the gene for the .gamma. chain of human fibrinogen

1985 • 69 citations

The protein component of human brain thromboplastin

1973 • 69 citations

Purification and characterization of the protein component of tissue factor

1970 • 68 citations

THE THROMBOPLASTIC PROTEIN: STRUCTURE, PROPERTIES, DISINTEGRATION

1944 • 66 citations

Plasma high density lipoproteins inhibit the activation of coagulation factor X by factor VIIa and tissue factor

1981 • 63 citations

ULTRACENTRIFUGAL ISOLATION FROM LUNG TISSUE OF A MACROMOLECULAR PROTEIN COMPONENT WITH THROMBOPLASTIC PROPERTIES

1942 • 60 citations

Comparison of procoagulant activity in tissue culture medium from normal and transformed fibroblasts.

1978 • 57 citations

Cellular requirements for tissue factor generation by bovine aortic endothelial cells in culture

1985 • 57 citations

Interleukin 1 Stimulates Endothelial Cell Tissue Factor Production and Expression by a Prostaglandin-Independent Mechanism

1986 • 57 citations

Continuous chromogenic tissue factor assay: Comparison to clot-based assays and sensitivity established using pure tissue factor

1987 • 55 citations

Bronchoalveolar Lavage Procoagulant Activity in Bleomycin-Induced Lung Injury in Marmosets: Characterization and Relationship to Fibrin Deposition and Fibrosis

1987 • 55 citations

Warfarin inhibits both procoagulant activity and metastatic capacity of Lewis Lung Carcinoma cells

1983 • 54 citations

DEMONSTRATION OF ANTITHROMBOPLASTIC ACTIVITY IN NORMAL AND HEMOPHILIC PLASMAS

1943 • 53 citations

Initiation of the extrinsic pathway of coagulation. Association of factor VIIa with a cell line expressing tissue factor.

1987 • 52 citations

Monocyte procoagulant activity in glomerulonephritis associated with systemic lupus erythematosus.

1985 • 52 citations

The Activity of Lung Microsomes in Blood Coagulation

1964 • 51 citations

Tissue factor activity of normal and neoplastic cells: quantitation and species specificity.

1983 • 51 citations

Binding of the protein component of tissue factor to phospholipids

1970 • 50 citations

Membrane-dependent coagulation reaction is independent of the concentration of phospholipid-bound substrate: fluid phase factor X regulates the extrinsic system.

1986 • 49 citations

The HLA-D-associated invariant chain binds palmitic acid at the cysteine adjacent to the membrane segment.

1986 • 49 citations

The Activation of Factor X by Extracts of Rabbit Brain

1964 • 47 citations

Tissue factor activity in hela cells measured with a continuous chromogenic assay and elisa reader

1986 • 45 citations

Tissue factor (coagulation factor III) inhibition by apolipoprotein A-II.

1987 • 45 citations

Characteristics and lipid requirements of coagulant proteins extracted from lung and brain: the specificity of the protein component of tissue factor

1969 • 44 citations

Platelet effects on tissue factor and fibrinolytic inhibition of cultured human fibroblasts and vascular cells

1982 • 40 citations

IDENTIFICATION OF A THROMBOPLASTIN INHIBITOR IN SERUM AND IN PLASMA 1

1953 • 39 citations

Partial purification and characterization of extrinsic pathway inhibitor (the factor xa-dependent plasma inhibitor of factor VIIa/tissue factor)

1987 • 39 citations

The Activity of Human Placenta Microsomes and Brain Particles in Blood Coagulation

1966 • 39 citations

Monoclonal antibodies against bovine tissue factor, which block interaction with factor VIIa

1985 • 36 citations

The number of receptors for factor VII correlates with the ability of cultured cells to initiate coagulation

1984 • 36 citations

Interaction of the hemostatic and immune systems in the metastatic spread of tumor cells.

1986 • 36 citations

Concanavalin A Inhibition of Tissue Factor (Thromboplastin) Activity

1974 • 36 citations

Studies on Tissue Thromboplastin - Its Splitting into Two Separable Parts

1969 • 35 citations

STUDIES ON THE MECHANISM OF THE THROMBOPLASTIC EFFECT

1948 • 31 citations

Tumor interaction with hemostasis: The rationale for the use of platelet inhibitors and anticoagulants in the treatment of cancer

1984 • 31 citations

Effect of immune complex-containing sera from patients with rheumatic diseases on thromboplastin activity of monocytes

1982 • 31 citations

Inhibition of experimental blood-borne lung metastasis by protease inhibitors.

1980 • 30 citations

Induction of monocyte-macrophage procoagulant activity by transformed cell lines.

1986 • 28 citations

ON THE EVOLUTION OF BLOOD CLOTTING THEORY

1952 • 27 citations

In vitro generation of procoagulant activity by leukemic promyelocytes in reponse to cytotoxic drugs

1985 • 24 citations

Immunoaffinity purification of bovine factor VII

1984 • 24 citations

Isolation and characterization of human blood-coagulation factor X cDNA

1986 • 22 citations

Dipyridamole stimulates urokinase production and suppresses procoagulant activity of rabbit alveolar macrophages: a possible mechanism of antithrombotic action

1987 • 21 citations

Studies on the intravascular thromboplastic effect of tissue suspensions in mice: a factor in normal rabbit serum which inhibits the thromboplastic effect of the sedimentable tissue component.

1947 • 21 citations

Dipyridamole stimulates urokinase production and suppresses procoagulant activity of rabbit alveolar macrophages: a possible mechanism of antithrombotic action

1987 • 21 citations

Thromboplastin activity of mouse peritoneal macrophages

1981 • 19 citations

Binding of bovine brain tissue factor to concanavalin asepharose. Partial purification of coagulant, arylamidase, and alkaline phosphatase activities

1976 • 19 citations

Studien über Gewebethromboplastin.

1964 • 19 citations

The significance of elevated procoagulant activity in the monocytes of renal transplant recipients.

1982 • 17 citations

Skeletal muscle metabolism in mice bearing adenocarcinoma III. Activities of alanine and aspartate aminotransferases

1986 • 17 citations

The role of activated factor X in the control of bovine coagulation factor VII.

1981 • 16 citations

Fibrin Formation: Implications for Tumor Growth and Metastasis

1984 • 15 citations

Inhibition of the arrest of hematogenously disseminated tumor cells

1983 • 14 citations

Synthesis of Thromboplastin Protein by a Murine Macrophage-Like Cell Line

1982 • 12 citations

Aspartokinase I-homoserine dehydrogenase I of Escherichia coli K12 (lambda). Activation by monovalent cations and an analysis of the effect of the adenosine triphosphate-magnesium ion complex on this activation process.

1975 • 12 citations

Tissue factor in cultured cells: metabolic control.

1976 • 12 citations

Further Studies on the Modulation of Blood Coagulation by Human Serum Amyloid P Component and Its Acute Phase Homologue C-Reactive Protein

1986 • 11 citations

The Interaction of the Protein and Phospholipid Components of Tissue Thromboplastin (Factor III) with the Factors VII and X

1975 • 10 citations

Tissue factor in cultured cells: pharmacologic effects.

1976 • 10 citations

Amidolytic assay for procoagulant activity of lymphoid and tumor cells

1986 • 7 citations

The development of monospecific antibodies against human thrombo-plastin apoprotein (apoprotein III) and their application in the immunocytochemical detection of the antigen in blood cells

1987 • 6 citations

Coagulation factor III (tissue factor) interaction with phospholipid vesicles induced by cadmium: characterization of the reconstituted protein-membrane complex

1981 • 5 citations

Development of Tissue Factor Activity in Mononuclear Cells Cultured in Vitro

1978 • 3 citations

Falsely prolonged prothrombin time due to an inhibitor to human thromboplastin

1984 • 2 citations

Is hemophilia a disease of the tissue factor pathway of coagulation?

1981 • 2 citations