The nature of autoantigens targeted in autoimmune endocrine diseases

Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

1990 • 1,955 citations

Type I Diabetes Mellitus

1986 • 1,615 citations

ISLET-CELL ANTIBODIES IN DIABETES MELLITUS WITH AUTOIMMUNE POLYENDOCRINE DEFICIENCIES

1974 • 1,463 citations

Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes

1993 • 1,087 citations

Insulin Antibodies in Insulin-Dependent Diabetics Before Insulin Treatment

1983 • 1,078 citations

Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice

1993 • 962 citations

Autoimmune Thyroid Disease: Further Developments in Our Understanding*

1994 • 611 citations

Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins

1982 • 531 citations

Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus.

1992 • 494 citations

Autoimmune Polyglandular Syndromes

1980 • 467 citations

LKM-1 autoantibodies recognize a short linear sequence in P450IID6, a cytochrome P-450 monooxygenase.

1991 • 455 citations

Antibodies That Impair Insulin Receptor Binding in an Unusual Diabetic Syndrome with Severe Insulin Resistance

1975 • 434 citations

Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice.

1995 • 428 citations

21-hydroxylase, a major autoantigen in idiopathic Addison's disease

1992 • 403 citations

Major antigen of liver kidney microsomal autoantibodies in idiopathic autoimmune hepatitis is cytochrome P450db1.

1989 • 363 citations

A bovine albumin peptide as a possible trigger of insulin-dependent diabetes mellitus

1994 • 336 citations

Antibodies to a 64,000 Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetes.

1987 • 319 citations

Molecular Cloning and Identification of a Receptor-Type Protein Tyrosine Phosphatase, IA-2, from Human Insulinoma

1994 • 317 citations

Islet cell antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases.

1994 • 308 citations

Insulitis and Diabetes in NOD Mice Reduced by Prophylactic Insulin Therapy

1990 • 296 citations

A Prospective Study of the Development of Diabetes in Relatives of Patients with Insulin-Dependent Diabetes

1990 • 288 citations

Glutamate decarboxylase-, insulin-, and islet cell-antibodies and HLA typing to detect diabetes in a general population-based study of Swedish children.

1995 • 255 citations

Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-gamma transcription.

1995 • 248 citations

Islet cell autoantigen 69 kD (ICA69). Molecular cloning and characterization of a novel diabetes-associated autoantigen.

1993 • 236 citations

Autoantibodies to the extracellular domain of the calcium sensing receptor in patients with acquired hypoparathyroidism.

1996 • 236 citations

Major parietal cell antigen in autoimmune gastritis with pernicious anemia is the acid-producing H+,K+-adenosine triphosphatase of the stomach.

1988 • 227 citations

Identification by molecular cloning of an autoantigen associated with Addison's disease as steroid 17α-hydroxylase

1992 • 201 citations

The incidence of parathyroid and other antibodies in the sera of patients with idiopathic hypoparathyroidism.

1966 • 199 citations

The role of tyrosinase in autoimmune vitiligo

1994 • 198 citations

Autoimmune Vitiligo

1977 • 193 citations

Autoantibodies to cytochrome P450 enzymes P450scc, P450c17, and P450c21 in autoimmune polyglandular disease types I and II and in isolated Addison's disease.

1994 • 182 citations

Cytotoxic T cells specific for glutamic acid decarboxylase in autoimmune diabetes.

1995 • 173 citations

An autoimmune disease with multiple molecular targets abrogated by the transgenic expression of a single autoantigen in the thymus.

1993 • 168 citations

Identification and Cloning of a Granule Autoantigen (Carboxypeptidase-H) Associated with Type I Diabetes*

1991 • 160 citations

Evidence for the role of CD8+ cytotoxic T cells in the destruction of pancreatic beta-cells in nonobese diabetic mice.

1994 • 157 citations

Islet cell autoantigens in insulin-dependent diabetes.

1993 • 136 citations

Islet cell antibodies predict insulin-dependent diabetes in United States school age children as powerfully as in unaffected relatives.

1994 • 134 citations

ANTIBODY TO CULTURED HUMAN INSULINOMA CELLS IN INSULIN-DEPENDENT DIABETES

1975 • 132 citations

CTL specific for the tyrosinase autoantigen can be induced from healthy donor blood to lyse melanoma cells.

1995 • 124 citations

Cloning and Expression of IDDM-Specific Human Autoantigens

1992 • 118 citations

Antibodies producing complement-mediated thyroid cytotoxicity in patients with atrophic or goitrous autoimmune thyroiditis.

1993 • 115 citations

Distinct antibody specificities to a 64-kD islet cell antigen in type 1 diabetes as revealed by trypsin treatment.

1990 • 114 citations

RETROVIRUS-LIKE SEQUENCES IN GRAVES' DISEASE: IMPLICATIONS FOR HUMAN AUTOIMMUNITY

1989 • 113 citations

AUTOIMMUNITY TO ANTERIOR PITUITARY CELLS AND THE PATHOGENESIS OF INSULIN-DEPENDENT DIABETES MELLITUS

1982 • 108 citations

Gonadal Autoantibodies in Patients with Hypogonadism and/or Addison's Disease*

1981 • 102 citations

Insulitis and diabetes in NOD mice reduced by prophylactic insulin therapy

1990 • 97 citations

Beta-cell-cytotoxic CD8+ T cells from nonobese diabetic mice use highly homologous T cell receptor alpha-chain CDR3 sequences.

1995 • 93 citations

Molecular targets in pernicious anaemia

1991 • 91 citations

Changes in stimulating and blocking TSH receptor antibodies in a patient undergoing three cycles of transition from hypo to hyper‐thyroidism and back to hypothyroidism

1992 • 87 citations

Autoantibodies in Nonobese Diabetic Mice Immunoprecipitate 64,000-Mr Islet Antigen

1988 • 86 citations

Imogen 38: a novel 38-kD islet mitochondrial autoantigen recognized by T cells from a newly diagnosed type 1 diabetic patient.

1996 • 85 citations

Immunoprecipitation assay for autoantibodies to steroid 21-hydroxylase in autoimmune adrenal diseases

1995 • 80 citations

Detection of pancreatic islet 64,000 M(r) autoantigens in insulin-dependent diabetes distinct from glutamate decarboxylase.

1993 • 79 citations

Parathyroid cell surface autoantibodies that inhibit parathyroid hormone secretion from dispersed human parathyroid cells

1986 • 76 citations

Presentation of beta-cell antigens to CD4+ and CD8+ T cells of non-obese diabetic mice.

1993 • 75 citations

T cell peptide of a self-protein elicits autoantibody to the protein antigen. Implications for specificity and pathogenetic role of antibody in autoimmunity.

1993 • 73 citations

Autoimmune Diseases of the Adrenal Glands, Parathyroid Glands, Gonads, and Hypothalamic-Pituitary Axis

1991 • 72 citations

Ultrastructural localization of gastric parietal cell antigen with peroxidase-coupled antibody.

1970 • 64 citations

Autoantibodies to cytochrome P450 enzymes P450scc, P450c17, and P450c21 in autoimmune polyglandular disease types I and II and in isolated Addison's disease

1994 • 61 citations

Autoimmune Addison's disease--evidence for a role of steroid 21-hydroxylase autoantibodies in adrenal insufficiency.

1994 • 53 citations

Antibodies producing complement-mediated thyroid cytotoxicity in patients with atrophic or goitrous autoimmune thyroiditis

1993 • 52 citations

Inhibition of parietal cell function by human gammaglobulin containing gastric parietal cell antibodies.

1980 • 52 citations

Human Foamy Virus Antigens in Thyroid Tissue of Graves’ Disease Patients

1992 • 50 citations

Identification of thyroid stimulating hormone receptor-specific T cells in Graves' disease thyroid using autoantigen-transfected Epstein-Barr virus-transformed B cell lines.

1995 • 50 citations

Surface-reactive antibodies to human adrenal cells in Addison's disease.

1981 • 44 citations

Cloning and expression of IDDM-specific human autoantigens

1992 • 43 citations

Effect of anti-thyroxin autoantibodies on radioimmunoassay of free thyroxin in serum.

1982 • 42 citations

Autoantibodies in nonobese diabetic mice immunoprecipitate 64,000-Mr islet antigen

1988 • 40 citations

Nucleotide and amino acid homology between the human thyrotropin receptor and the HIV-1 nef protein: Identification and functional analysis

1991 • 39 citations

Autoantibodies To The Tsh Receptor In Patients With Autoimmune Thyroid Disease

1990 • 37 citations

Antigen-specific T cell recognition of affinity-purified and recombinant thyroid peroxidase in autoimmune thyroid disease

1992 • 30 citations

Autoantibodies to Zona Pellucida in Infertile and Aged Women

1980 • 26 citations

Localization of a Pernicious Anaemia Autoantibody Epitope on the a'-Subunit of Human H,K-Adenosine Triphosphatase

1994 • 26 citations

Proliferative responses of T-cells to thyroid antigens and synthetic thyroid peroxidase peptides in autoimmune thyroid disease.

1995 • 23 citations

Autoimmune Addison's disease--evidence for a role of steroid 21- hydroxylase autoantibodies in adrenal insufficiency

1994 • 21 citations

Heterogeneity of Autoantibodies against Thyroid Peroxidase in Autoimmune Thyroid Disease: Evidence against Antibodies Directly Inhibiting Peroxidase Activity as Regulatory Factors in Thyroid Hormone Metabolism

1991 • 20 citations

T-Lymphocyte Lines Specific for Glutamic Acid Decarboxylase (GAD) the 64K β-Cell Antigen of IDDM

1992 • 20 citations

Diffusion artefacts and tissue fixation in thyroperoxidase cytochemistry

1984 • 16 citations

Autoantibody epitope mapping of the 21-hydroxylase antigen in autoimmune Addison's disease

1994 • 16 citations

Proliferative responses of T-cells to thyroid antigens and synthetic thyroid peroxidase peptides in autoimmune thyroid disease

1995 • 10 citations

T-lymphocyte lines specific for glutamic acid decarboxylase (GAD) the 64K beta-cell antigen of IDDM

1992 • 10 citations

Which glycolipids are the autoantigens of cytoplasmatic islet cell antibodies?

1992 • 7 citations