Isolation of a high affinity scFv from a monoclonal antibody recognising the oncofoetal antigen 5T4

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

1997 • 5,522 citations

A rapid, sensitive, and versatile assay for protein using Coomassie brilliant blue G250

1977 • 2,970 citations

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product.

1985 • 2,456 citations

The leucine-rich repeat: a versatile binding motif

1994 • 1,209 citations

Immunoblotting and dot immunobinding — Current status and outlook

1984 • 979 citations

Rapid tumor penetration of a single-chain Fv and comparison with other immunoglobulin forms.

1992 • 824 citations

A transient three-plasmid expression system for the production of high titer retroviral vectors

1995 • 686 citations

Human immune response to multiple injections of murine monoclonal IgG.

1985 • 425 citations

The influence of polyvalency on the binding properties of antibodies

1972 • 396 citations

Construction, binding properties, metabolism, and tumor targeting of a single-chain Fv derived from the pancarcinoma monoclonal antibody CC49.

1991 • 342 citations

In Vivo Tumor Targeting of a Recombinant Single-Chain Antigen-Binding Protein

1990 • 304 citations

Limitations of radiolabeled monoclonal antibodies for localization of human neoplasms.

1986 • 283 citations

Chaoptin, a cell surface glycoprotein required for Drosophila photoreceptor cell morphogenesis, contains a repeat motif found in yeast and human

1988 • 218 citations

Development of primary and secondary immune responses to mouse monoclonal antibodies used in the diagnosis and therapy of malignant neoplasms.

1986 • 209 citations

Immunohistological distribution of 5T4 antigen in normal and malignant tissues

1990 • 177 citations

The Drosophila 18 wheeler is required for morphogenesis and has striking similarities to Toll

1994 • 141 citations

The Drosophila melanogaster flightless-I gene involved in gastrulation and muscle degeneration encodes gelsolin-like and leucine-rich repeat domains and is conserved in Caenorhabditis elegans and humans.

1993 • 127 citations

A 72 kD trophoblast glycoprotein defined by a monoclonal antibody

1988 • 124 citations

Monoclonal antibody-superantigen fusion proteins: tumor-specific agents for T-cell-based tumor therapy.

1994 • 121 citations

Prognostic significance of 5T4 oncofetal antigen expression in colorectal carcinoma

1994 • 117 citations

Monoclonal antibodies in the detection and therapy of micrometastatic epithelial cancers

1992 • 116 citations

Connectin, a target of homeotic gene control inDrosophila

1992 • 107 citations

Determination of the binding affinity of an anti-CD34 single-chain antibody using a novel, flow cytometry based assay

1997 • 95 citations

5T4 oncofetal antigen expression in ovarian carcinoma

1995 • 84 citations

Superantigen-based immunotherapy: a phase I trial of PNU-214565, a monoclonal antibody-staphylococcal enterotoxin A recombinant fusion protein, in advanced pancreatic and colorectal cancer.

1997 • 82 citations

Repeated antitumour antibody therapy in man with suppression of the host response by cyclosporin A

1988 • 81 citations

Radioimmunoguided surgery in colorectal cancer using a genetically engineered anti-CEA single-chain Fv antibody.

2000 • 76 citations

Isolation of a cDNA encoding 5T4 oncofetal trophoblast glycoprotein. An antigen associated with metastasis contains leucine-rich repeats.

1994 • 72 citations

The expression of 5T4 antigen in colorectal and gastric carcinoma

1992 • 72 citations

Metastasis-associated 5T4 antigen disrupts cell-cell contacts and induces cellular motility in epithelial cells

1996 • 71 citations

Monoclonal antibodies in cancer therapy

1993 • 71 citations

Targeting of interleukin 2 to human ovarian carcinoma by fusion with a single-chain Fv of antifolate receptor antibody.

1998 • 65 citations

Isolation and characterization of 5T4, a tumour‐associated antigen

1990 • 65 citations

Microdistribution of specific rat monoclonal antibodies to mouse tissues and human tumor xenografts.

1991 • 57 citations

キイロショウジョウバエの原腸形成や筋退行変性に関与するflightless-I遺伝子はゲルゾリン様及びにロイシン富有反復ドメインをコードし、Caenor-habdits elegantsとヒトで保存される

1993 • 56 citations

Characterization of a recombinant single-chain molecule comprising the variable domains of a monoclonal antibody specific for human fibrin fragment D-dimer.

1991 • 49 citations

Metastasis-associated 5T4 oncofoetal antigen is concentrated at microvillus projections of the plasma membrane

1995 • 45 citations

Expression of a novel Toll-like gene spans the parasegment boundary and contributes to hedgehog function in the adult eye of Drosophila

1994 • 40 citations

Superantigen-targeted therapy: phase I escalating repeat dose trial of the fusion protein PNU-214565 in patients with advanced gastrointestinal malignancies.

1998 • 40 citations

Organisation of the mouse and human 5T4 oncofoetal leucine-rich glycoprotein genes and expression in foetal and adult murine tissues

1999 • 37 citations

Human single-chain Fv immunoconjugates targeted to a melanoma-associated chondroitin sulfate proteoglycan mediate specific lysis of human melanoma cells by natural killer cells and complement

1999 • 37 citations

Staphylococcal Enterotoxin-Dependent Cell-Mediated Cytotoxicity

1991 • 36 citations

Cytotoxic and antitumor activity of a recombinant tumor necrosis factor-B1(Fv) fusion protein on LeY antigen-expressing human cancer cells.

1996 • 31 citations

Costimulation of T-cell proliferation by a chimeric B7-antibody fusion protein

1997 • 21 citations

[Use of antibodies or their fragments for the treatment of tumors].

1998 • 1 citations