Ionophore-induced apoptosis: Role of DNA fragmentation and calcium fluxes

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Cell Death: The Significance of Apoptosis

1980 • 7,281 citations

Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

1980 • 4,591 citations

Biological Applications of Ionophores

1976 • 1,829 citations

Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis

1989 • 1,739 citations

Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis

1984 • 1,586 citations

Calcium Dependence of Toxic Cell Death: A Final Common Pathway

1979 • 1,478 citations

Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.

1984 • 1,441 citations

Chromatin sub-structure. The digestion of chromatin DNA at regularly spaced sites by a nuclear deoxyribonuclease

1973 • 1,176 citations

Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic cultures

1989 • 1,159 citations

Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis

1990 • 945 citations

Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes.

1987 • 923 citations

Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation.

1988 • 909 citations

Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis.

1988 • 889 citations

Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins and hyperthermia

1990 • 887 citations

Role of Ca2+ in toxic cell killing

1989 • 856 citations

Erythropoietin Retards DNA Breakdown and Prevents Programmed Death in Erythroid Progenitor Cells

1990 • 837 citations

Death and the cell

1986 • 616 citations

Glucocorticoids activate a suicide process in thymocytes through an elevation of cytosolic Ca2+ concentration

1989 • 549 citations

2,3,7,8-Tetrachlorodibenzo- p -Dioxin Kills Immature Thymocytes by Ca ²⁺ -Mediated Endonuclease Activation

1988 • 460 citations

Cell Death Mechanisms and the Immune System

1991 • 459 citations

Antibodies to a soluble form of a tumor necrosis factor (TNF) receptor have TNF-like activity.

1990 • 396 citations

IL-2 addiction: withdrawal of growth factor activates a suicide program in dependent T cells.

1986 • 380 citations

Extracellular ATP as a trigger for apoptosis or programmed cell death.

1991 • 342 citations

Calcium-dependent killing of immature thymocytes by stimulation via the CD3/T cell receptor complex.

1989 • 315 citations

Characterization of binding and biological effects of monoclonal antibodies against a human tumor necrosis factor receptor.

1990 • 263 citations

Radiation-induced Interphase Death of Rat Thymocytes is Internally Programmed (Apoptosis)

1988 • 239 citations

Rabbit tumor necrosis factor: mechanism of action

1981 • 199 citations

Purified perforin induces target cell lysis but not DNA fragmentation.

1989 • 162 citations

Endogenous nuclease. Properties and effects on transcribed genes in chromatin.

1982 • 159 citations

DNA in chromatin of irradiated lymphoid tissues degrades in vivo into regular fragments

1976 • 145 citations

DNA fragmentation and cytotoxicity caused by tumor necrosis factor is enhanced by interferon‐γ

1987 • 127 citations

Calcium ion concentrations and DNA fragmentation in target cell destruction by murine cloned cytotoxic T lymphocytes.

1988 • 120 citations

Plasma membrane potential modulates chemotactic peptide-stimulated cytosolic free Ca2+ changes in human neutrophils.

1987 • 112 citations

CYTOLYTIC ACTION OF CORTICOSTEROIDS ON THYMUS AND LYMPHOMA CELLS IN VITRO

1967 • 79 citations

Correlation between the anticellular and DNA fragmenting activities of tumor necrosis factor.

1988 • 78 citations

Zn⁺⁺ inhibits both tumor necrosis factor‐mediated DNA fragmentation and cytolysis

1989 • 74 citations

Dna fragmentation and cell death mediated by t cell antigen receptor/cd3 complex on a leukemia t cell line^*

1989 • 70 citations

Protection of Chinese Hamster Ovary Cells from Hyperthermic Killing by Cycloheximide or Puromycin

1986 • 69 citations

Tumor necrosis factor induces synthesis of two proteins in human fibroblasts.

1986 • 65 citations

Induction of apoptosis (programmed cell death) in tumour cell lines by widely diverging stimuli

1990 • 58 citations

Inhibitory effect of progesterone on cell death of mouse uterine epithelium

1989 • 54 citations

What is apoptosis?

1986 • 49 citations

Destruction of the nuclear morphology of thymic lymphocytes by the corticosteroid cortisol

1968 • 48 citations

Commentary

1986 • 35 citations

Inhibition of DNA excision repair by methotrexate in Chinese hamster ovary cells following exposure to ultraviolet irradiation or ethylmethanesulfonate.

1990 • 25 citations

Protection by cycloheximide against cytotoxicity induced by vincristine, colchicine, or delta 12-prostaglandin J2 on human osteosarcoma cells.

1989 • 21 citations