Intron/exon structure of the human gene for the muscle isozyme of glycogen phosphorylase

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

The interpretation of protein structures: Estimation of static accessibility

1971 • 5,771 citations

Organization and Expression of Eucaryotic Split Genes Coding for Proteins

1981 • 4,730 citations

Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ

1977 • 4,696 citations

Why genes in pieces?

1978 • 2,256 citations

Chemical and biological evolution of a nucleotide-binding protein

1974 • 1,457 citations

Structural patterns in globular proteins

1976 • 1,286 citations

The isolation and characterization of linked δ- and β-globin genes from a cloned library of human DNA

1978 • 1,055 citations

Loops in Globular Proteins: A Novel Category of Secondary Structure

1986 • 533 citations

Sequence, structure and activity of phosphoglycerate kinase: a possible hinge-bending enzyme

1979 • 452 citations

Crystal structure of cat muscle pyruvate kinase at a resolution of 2.6 Å

1979 • 444 citations

Correlation of DNA exonic regions with protein structural units in haemoglobin

1981 • 394 citations

Splice Junctions: Association with Variation in Protein Structure

1983 • 261 citations

Complete amino acid sequence of rabbit muscle glycogen phosphorylase.

1977 • 229 citations

The Structures and Related Functions of Phosphorylase a

1980 • 197 citations

The triosephosphate isomerase gene from maize introns antedate the plant-animal divergence

1986 • 188 citations

Interactive program for visualization and modelling of proteins, nucleic acids and small molecules

1986 • 163 citations

Structure of maltoheptaose by difference Fourier methods and a model for glycogen

1982 • 161 citations

Intron–exon splice junctions map at protein surfaces

1982 • 148 citations

Response of global deep-water circulation to Earth's climatic change 135,000–107,000 years ago

1985 • 145 citations

Intron/exon structure of the chicken pyruvate kinase gene

1985 • 144 citations

Sequence analysis of the cDNA encoding human liver glycogen phosphorylase reveals tissue-specific codon usage.

1986 • 116 citations

Structure of the human phosphoglycerate kinase gene and the intron-mediated evolution and dispersal of the nucleotide-binding domain.

1985 • 116 citations

Relationship between the total size of exons and introns in protein-coding genes of higher eukaryotes.

1982 • 114 citations

Synergistic regulation of phosphorylase a by glucose and caffeine.

1978 • 113 citations

The structure of glycogen phosphorylase a at 2.5 Å resolution

1979 • 113 citations

Compact units in proteins

1986 • 105 citations

Structure of glycogen phosphorylase a at 3.0 A resolution and its ligand binding sites at 6 A.

1976 • 99 citations

The complete amino acid sequence of potato alpha-glucan phosphorylase.

1986 • 94 citations

Evolution of catalytic and regulatory sites in phosphorylases

1985 • 91 citations

Convergent and divergent evolution of regulatory sites in eukaryotic phosphorylases

1986 • 85 citations

Catalytic site of glycogen phosphorylase: structure of the T state and specificity for .alpha.-D-glucose

1982 • 83 citations

Structural aspects of the catalytic and regulatory function of glycogen phosphorylase

1981 • 82 citations

Correlation of exons with structural domains in alcohol dehydrogenase.

1984 • 78 citations

Intron-dependent evolution of chicken glyceraldehyde phosphate dehydrogenase gene

1985 • 75 citations

Complete cDNA sequence for rabbit muscle glycogen phosphorylase

1986 • 73 citations

Multidomain proteins — structure and evolution

1987 • 72 citations

Glycogen phosphorylase structures and function

1982 • 62 citations

Protein structure and gene organization of mouse lactate dehydrogenase‐A isozyme

1985 • 60 citations

Intron-dependent evolution of the nucleotide-binding domains within alcohol dehydrogenase and related enzymes

1986 • 50 citations

Comparison of AMP and NADH binding to glycogen phosphorylase b

1983 • 49 citations

Comparative sequence analysis of rat, rabbit, and human muscle glycogen phosphorylase cDNAs

1985 • 43 citations

Analysis of the surface topography of glycogen phosphorylase a: implications for metabolic interconversion and regulatory mechanisms

1979 • 38 citations

Cosmid vectors for high efficiency DNA-mediated transformation and gene amplification in mam- malian cells: studies with the human growth hormone gene

1986 • 35 citations

Subunit interactions and the allosteric response in phosphorylase

1980 • 29 citations

Solvent accessibility properties of complex proteins

1979 • 27 citations

Exons and the evolution of proteins

1983 • 20 citations

Assignment of the amino acid sequence to the crystal structure of glycogen phosphorylase b.

1978 • 4 citations